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Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study

White, Clare; Noble, Simon I R; Watson, Max; Swan, Flavia; Allgar, Victoria L; Napier, Eoin; Nelson, Annmarie; McAuley, Jayne; Doherty, Jennifer; Lee, Bernadette; Johnson, Miriam J

Authors

Clare White

Simon I R Noble

Max Watson

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Dr Flavia Swan F.Swan@hull.ac.uk
Research fellow in cancer rehabilitation

Victoria L Allgar

Eoin Napier

Annmarie Nelson

Jayne McAuley

Jennifer Doherty

Bernadette Lee



Abstract

Summary
Background
The prevalence of deep venous thrombosis in patients with advanced cancer is unconfirmed and it is unknown whether current international thromboprophylaxis guidance is applicable to this population. We aimed to determine prevalence and predictors of femoral deep vein thrombosis in patients admitted to specialist palliative care units (SPCUs).

Methods
We did this prospective longitudinal observational study in five SPCUs in England, Wales, and Northern Ireland (four hospices and one palliative care unit). Consecutive adults with cancer underwent bilateral femoral vein ultrasonography on admission and weekly until death or discharge for a maximum of 3 weeks. Data were collected on performance status, attributable symptoms, and variables known to be associated with venous thromboembolism. Patients with a short estimated prognosis (

Journal Article Type Article
Publication Date 2019-02
Journal The Lancet Haematology
Print ISSN 2352-3026
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 6
Issue 2
Pages e79-e88
APA6 Citation White, C., Noble, S. I. R., Watson, M., Swan, F., Allgar, V. L., Napier, E., …Johnson, M. J. (2019). Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study. Lancet Haematology, 6(2), e79-e88. doi:10.1016/s2352-3026(18)30215-1
DOI https://doi.org/10.1016/s2352-3026%2818%2930215-1
Keywords Hematology
Publisher URL https://www.sciencedirect.com/science/article/pii/S2352302618302151?via%3Dihub#!
Additional Information Copy of article first published in: Lancet Haematology, 2019, v.6, issue 2.

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Copyright Statement
©2019 The authors. This is an Open Access article under the CC BY-NC-ND 4.0 license.





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