Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study

White, Clare; Noble, Simon I R; Watson, Max; Swan, Flavia; Allgar, Victoria L; Napier, Eoin; Nelson, Annmarie; McAuley, Jayne; Doherty, Jennifer; Lee, Bernadette; Johnson, Miriam J.

Abstract

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Background: The prevalence of deep venous thrombosis in patients with advanced cancer is unconfirmed and it is unknown whether current international thromboprophylaxis guidance is applicable to this population. We aimed to determine prevalence and predictors of femoral deep vein thrombosis in patients admitted to specialist palliative care units (SPCUs). Methods: We did this prospective longitudinal observational study in five SPCUs in England, Wales, and Northern Ireland (four hospices and one palliative care unit). Consecutive adults with cancer underwent bilateral femoral vein ultrasonography on admission and weekly until death or discharge for a maximum of 3 weeks. Data were collected on performance status, attributable symptoms, and variables known to be associated with venous thromboembolism. Patients with a short estimated prognosis (

Citation

White, C., Noble, S. I. R., Watson, M., Swan, F., Allgar, V. L., Napier, E., …Johnson, M. J. (2019). Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study. The Lancet Haematology, 6(2), e79-e88. https://doi.org/10.1016/S2352-3026%2818%2930215-1

• Journal Article Type: Article
• Acceptance Date: Nov 20, 2018
• Online Publication Date: Jan 29, 2019
• Publication Date: Feb 1, 2019
• Deposit Date: Jan 30, 2019
• Publicly Available Date: Jan 31, 2019
• Journal: The Lancet Haematology
• Electronic ISSN: 2352-3026
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 2
• Pages: e79-e88
• DOI: https://doi.org/10.1016/S2352-3026%2818%2930215-1
• Keywords: Hematology
• Public URL: https://hull-repository.worktribe.com/output/1249458
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2352302618302151?via%3Dihub#!
• Additional Information: Copy of article first published in: Lancet Haematology, 2019, v.6, issue 2.