All Outputs (20)

Inequalities in living well with dementia—The impact of deprivation on well-being, quality of life and life satisfaction: Results from the improving the experience of dementia and enhancing active life study (2018)
Journal Article
Wu, Y. T., Clare, L., Jones, I. R., Martyr, A., Nelis, S. M., Quinn, C., …Matthews, F. E. (2018). Inequalities in living well with dementia—The impact of deprivation on well-being, quality of life and life satisfaction: Results from the improving the experience of dementia and enhancing active life study. International journal of geriatric psychiatry, 33(12), 1736-1742. https://doi.org/10.1002/gps.4998

Objectives: Area level factors, such as deprivation and urban/rural settings, have been associated with variation in local resources and services and health inequality in later life. The aim of this study is to investigate the potential impact of dep... Read More about Inequalities in living well with dementia—The impact of deprivation on well-being, quality of life and life satisfaction: Results from the improving the experience of dementia and enhancing active life study.

Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose (2018)
Journal Article
Wolpe, N., Zhang, J., Nombela, C., Ingram, J. N., Wolpert, D. M., Rowe, J. B., …Villis, L. (2018). Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose. Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-33678-3

Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly under... Read More about Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose.

Loneliness as a risk factor for care home admission in the english longitudinal study of ageing (2018)
Journal Article
Hanratty, B., Stow, D., Moore, D. C., Valtorta, N. K., & Matthews, F. (2018). Loneliness as a risk factor for care home admission in the english longitudinal study of ageing. Age and ageing, 47(6), 896-900. https://doi.org/10.1093/ageing/afy095

Background: loneliness has an adverse effect on health and well-being, and is common at older ages. Evidence that it is a risk factor for care home admission is sparse. Objective: to investigate the association between loneliness and care home admiss... Read More about Loneliness as a risk factor for care home admission in the english longitudinal study of ageing.

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality (2018)
Journal Article
Hayat, S. A., Luben, R., Dalzell, N., Moore, S., Hogervorst, E., Matthews, F. E., …Khaw, K. T. (2018). Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality. European Journal of Epidemiology, 33(11), 1049-1062. https://doi.org/10.1007/s10654-018-0439-z

Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemogr... Read More about Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.

Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain (2018)
Journal Article
Waller, R., Murphy, M., Garwood, C. J., Jennings, L., Heath, P. R., Chambers, A., …Simpson, J. E. (2018). Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain. Glia, 66(11), 2316-2323. https://doi.org/10.1002/glia.23465

Oxidative stress and oxidative DNA damage are early features of mild cognitive impairment and Alzheimer's disease (AD), occurring before the formation of classical AD neuropathology, and resulting from an imbalance between pro- and anti-oxidants. Ast... Read More about Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain.

Protocol for the IDEAL-2 longitudinal study: Following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life (2018)
Journal Article
Silarova, B., Nelis, S. M., Ashworth, R. M., Ballard, C., Bieńkiewicz, M., Henderson, C., …Clare, L. (2018). Protocol for the IDEAL-2 longitudinal study: Following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life. BMC public health, 18(1), https://doi.org/10.1186/s12889-018-6129-7

Background: There is a major need for longitudinal research examining the experiences of people with dementia and their primary carers, as relatively little is known about how the factors associated with capability to 'live well' vary over time. The... Read More about Protocol for the IDEAL-2 longitudinal study: Following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life.

Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities (2018)
Journal Article
Chan, D., Shafto, M., Kievit, R., Matthews, F., Spink, M., Valenzuela, M., & Henson, R. N. (2018). Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities. Neurobiology of Aging, 70, 180-183. https://doi.org/10.1016/j.neurobiolaging.2018.06.012

This study tested the hypothesis that mid-life intellectual, physical, and social activities contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic resonance imaging) aged 66–88 years from the Cambridge Centre for Agein... Read More about Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities.

Frailty trajectories to identify end of life: A longitudinal population-based study (2018)
Journal Article
Stow, D., Matthews, F. E., & Hanratty, B. (2018). Frailty trajectories to identify end of life: A longitudinal population-based study. BMC medicine, 16(1), https://doi.org/10.1186/s12916-018-1148-x

Background: Timely recognition of the end of life allows patients to discuss preferences and make advance plans, and clinicians to introduce appropriate care. We examined changes in frailty over 1 year, with the aim of identifying trajectories that c... Read More about Frailty trajectories to identify end of life: A longitudinal population-based study.

Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study (2018)
Journal Article
Wu, Y. T., Clare, L., Hindle, J. V., Nelis, S. M., Martyr, A., & Matthews, F. E. (2018). Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study. BMC medicine, 16(1), 140. https://doi.org/10.1186/s12916-018-1135-2

BACKGROUND: The heterogeneity of symptoms across dementia subtypes has important implications for clinical practice and dementia research. Variation in subtypes and associated symptoms may influence the capability to live well for people with dementi... Read More about Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study.

Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies (2018)
Journal Article
Mousa, A., Savva, G. M., Mitnitski, A., Rockwood, K., Jagger, C., Brayne, C., & Matthews, F. E. (2018). Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies. Age and ageing, 47(5), 721-727. https://doi.org/10.1093/ageing/afy077

Background: age-specific mortality reduction has been accompanied by a decrease in the prevalence of some diseases and an increase in others. Whether populations are becoming 'healthier' depends on which aspect of health is being considered. Frailty... Read More about Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies.

The impact of dementia on service use by individuals with a comorbid health condition: A comparison of two cross-sectional analyses conducted approximately 10 years apart (2018)
Journal Article
Bennett, H. Q., Norton, S., Bunn, F., Robinson, L., Rait, G., Goodman, C., …Matthews, F. E. (2018). The impact of dementia on service use by individuals with a comorbid health condition: A comparison of two cross-sectional analyses conducted approximately 10 years apart. BMC medicine, 16(1), https://doi.org/10.1186/s12916-018-1105-8

Background: The presence of concomitant medical conditions in people with dementia is common. Dementia may be related to differential use of health, social and informal care. Methods: Data from two large UK population-based studies (CFAS I & II) of a... Read More about The impact of dementia on service use by individuals with a comorbid health condition: A comparison of two cross-sectional analyses conducted approximately 10 years apart.

Accuracy of death certification of dementia in population-based samples of older people: Analysis over time (2018)
Journal Article
Gao, L., Calloway, R., Zhao, E., Brayne, C., & Matthews, F. E. (2018). Accuracy of death certification of dementia in population-based samples of older people: Analysis over time. Age and ageing, 47(4), 589-594. https://doi.org/10.1093/ageing/afy068

Background: death certification data are routinely collected in most developed countries. Coded causes of death are a readily accessible source and have the potential advantage of providing complete follow-up, but with limitations. Objective: to inve... Read More about Accuracy of death certification of dementia in population-based samples of older people: Analysis over time.

Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: Case control study (2018)
Journal Article
Stow, D., Matthews, F. E., Barclay, S., Iliffe, S., Clegg, A., De Biase, S., …Hanratty, B. (2018). Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: Case control study. Age and ageing, 47(4), 564-569. https://doi.org/10.1093/ageing/afy022

Background: recognising that a patient is nearing the end of life is essential, to enable professional carers to discuss prognosis and preferences for end of life care. Objective: investigate whether an electronic frailty index (eFI) generated from r... Read More about Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: Case control study.

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population (2018)
Journal Article
Hokkanen, S. R., Hunter, S., Polvikoski, T. M., Keage, H. A., Minett, T., Matthews, F. E., & Brayne, C. (2018). Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. Brain Pathology, 28(4), 548-559. https://doi.org/10.1111/bpa.12556

Hippocampal neuron loss is a common neuropathological feature in old age with various underlying etiologies. Hippocampal sclerosis of aging (HS-Aging) is neuropathologically characterized by severe CA1 neuronal loss and frequent presence of transacti... Read More about Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population.

Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (2018)
Journal Article
Green, E., Bennett, H., Brayne, C., Tyler, L. K., Bullmore, E. T., Calder, A. C., …Matthews, F. E. (2018). Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study. BMC public health, 18(1), https://doi.org/10.1186/s12889-018-5663-7

Background: With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult ages within a contempo... Read More about Exploring patterns of response across the lifespan: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study.

Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up (2018)
Journal Article
White, S. R., Muniz-Terrera, G., & Matthews, F. E. (2018). Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up. Statistical Methods in Medical Research, 27(5), 1476-1497. https://doi.org/10.1177/0962280216662298

Many medical (and ecological) processes involve the change of shape, whereby one trajectory changes into another trajectory at a specific time point. There has been little investigation into the study design needed to investigate these models. We con... Read More about Sample size and classification error for Bayesian change-point models with unlabelled sub-groups and incomplete follow-up.

Medication usage change in older people (65+) in England over 20 years: Findings from CFAS I and CFAS II (2018)
Journal Article
Gao, L., Maidment, I., Matthews, F. E., Robinson, L., & Brayne, C. (2018). Medication usage change in older people (65+) in England over 20 years: Findings from CFAS I and CFAS II. Age and ageing, 47(2), 220-225. https://doi.org/10.1093/ageing/afx158

Background: medical practice has changed over the last decades reflecting the ageing population, when multi-morbidity requiring multiple medications is more common. Objective: describe and quantify self-reported medicine use including both prescripti... Read More about Medication usage change in older people (65+) in England over 20 years: Findings from CFAS I and CFAS II.

Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses (2018)
Journal Article
Grasset, L., Matthews, F. E., Pérès, K., Foubert-Samier, A., Helmer, C., Dartigues, J. F., & Brayne, C. (2018). Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 490-497. https://doi.org/10.1016/j.dadm.2018.07.005

Introduction: The aims of this study are to examine the evolution of clinical dementia diagnosis over 3 decades and to investigate secular trends of dementia. Methods: Four cohorts covering a period from 1988 to 2013 were used: the Personnes Agées Qu... Read More about Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses.

Anticholinergic drugs and risk of dementia: Case-control study (2018)
Journal Article
Richardson, K., Fox, C., Maidment, I., Steel, N., Loke, Y. K., Arthur, A., …Savva, G. M. (2018). Anticholinergic drugs and risk of dementia: Case-control study. BMJ, 361, https://doi.org/10.1136/bmj.k1315

Objectives: To estimate the association between the duration and level of exposure to different classes of anticholinergic drugs and subsequent incident dementia. Design: Case-control study. Setting: General practices in the UK contributing to the Cl... Read More about Anticholinergic drugs and risk of dementia: Case-control study.

Cognitive reserve as a moderator of the negative association between mood and cognition: Evidence from a population-representative cohort (2018)
Journal Article
Opdebeeck, C., Matthews, F. E., Wu, Y. T., Woods, R. T., Brayne, C., & Clare, L. (2018). Cognitive reserve as a moderator of the negative association between mood and cognition: Evidence from a population-representative cohort. Psychological Medicine, 48(1), 61-71. https://doi.org/10.1017/S003329171700126X

Background Cognitive reserve (CR) has been associated with better cognitive function and lower risk of depression in older people, yet it remains unclear whether CR moderates the association between mood and cognition. This study aimed to investigate... Read More about Cognitive reserve as a moderator of the negative association between mood and cognition: Evidence from a population-representative cohort.