Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses

Grasset, Leslie; Matthews, Fiona E.; Pérès, Karine; Foubert-Samier, Alexandra; Helmer, Catherine; Dartigues, Jean François; Brayne, Carol

Abstract

Introduction: The aims of this study are to examine the evolution of clinical dementia diagnosis over 3 decades and to investigate secular trends of dementia. Methods: Four cohorts covering a period from 1988 to 2013 were used: the Personnes Agées Quid and Three-City-Bordeaux studies, and the Cognitive Function and Aging Study (CFAS) I and II. Mini–Mental State Examination scores at clinical diagnosis were evaluated over a 24-year follow-up period in French studies. An algorithmic approach was applied to CFAS I and II to provide dementia prevalence and incidence estimates. Results: A significant increase of the Mini–Mental State Examination score at diagnosis was observed until 2000 and a significant decrease after. We reported a prevalence of 8.8% for CFAS I (1990–1993) compared with a prevalence of 6.5% in CFAS II (2008–2011). The 2-year incidence rate was estimated at 31.2/1000 (95% confidence interval = 28.0–34.8) for CFAS I and 15.0/1000 (95% confidence interval = 13.5–16.7) for CFAS II. Discussion: Applying a stable algorithm to different cohorts across time can provide a robust method for time trends estimation.

Citation

Grasset, L., Matthews, F. E., Pérès, K., Foubert-Samier, A., Helmer, C., Dartigues, J. F., & Brayne, C. (2018). Evolution of dementia diagnosis over time (1988–2013): Evidence from French and English cohorts. Implication for secular trends analyses. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 490-497. https://doi.org/10.1016/j.dadm.2018.07.005

• Journal Article Type: Article
• Publication Date: Jan 1, 2018
• Deposit Date: Dec 8, 2023
• Journal: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
• Electronic ISSN: 2352-8729
• Publisher: Wiley Open Access
• Volume: 10
• Pages: 490-497
• DOI: https://doi.org/10.1016/j.dadm.2018.07.005
• Public URL: https://hull-repository.worktribe.com/output/4452870