Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review

Boland, J. W.; McWilliams, K.; Ahmedzai, S. H.; Pockley, A. G.

doi:10.1038/bjc.2014.384

Effects of Opioids on Immune and Endocrine Function in Patients with Cancer Pain (2023)
Journal Article
Bradley, A., & Boland, J. W. (2023). Effects of Opioids on Immune and Endocrine Function in Patients with Cancer Pain. Current Treatment Options in Oncology, 24(7), 867-879. https://doi.org/10.1007/s11864-023-01091-2

Opioids are an important treatment in managing cancer pain. Uncontrolled pain can be detrimental to function and quality of life. Common adverse effects of opioids such as sedation, constipation and nausea are well recognised, but opioid effects on t... Read More about Effects of Opioids on Immune and Endocrine Function in Patients with Cancer Pain.

Parental death: a systematic review of support experiences and needs of children and parent survivors (2022)
Journal Article
Wray, A., Pickwell-Smith, B., Greenley, S., Pask, S., Bamidele, O., Wright, B., …Boland, J. W. (2022). Parental death: a systematic review of support experiences and needs of children and parent survivors. BMJ supportive & palliative care, https://doi.org/10.1136/spcare-2022-003793

Background: Bereaved people need a supportive response from those around them. Knowing children's and surviving parents' needs following parental death is the first step to ensuring a supportive response. However, no systematic review has reported on... Read More about Parental death: a systematic review of support experiences and needs of children and parent survivors.

Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review (2022)
Journal Article
Baddeley, E., Mann, M., Bravington, A., Johnson, M. J., Currow, D., Murtagh, F. E., …Noble, S. (in press). Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review. Palliative medicine, https://doi.org/10.1177/02692163221081331

Background: Malignant bowel obstruction occurs in up to 50% of people with advanced ovarian and 15% of people with gastrointestinal cancers. Evaluation and comparison of interventions to manage symptoms are hampered by inconsistent evaluations of eff... Read More about Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review.

Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis (2021)
Journal Article
Featherstone, I., Sheldon, T., Woodhouse, R., Boland, J. W., Hosie, A., Lawlor, P. G., …Johnson, M. (in press). Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis. Palliative medicine, https://doi.org/10.1177/02692163211065278

Background: Delirium is common and distressing for patients receiving palliative care. Interventions targetting modifiable risk factors in other settings have been shown to prevent delirium. Research on delirium risk factors in palliative care can in... Read More about Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis.

Delirium screening practice in specialist palliative care units: A survey (2020)
Journal Article
Woodhouse, R., Siddiqi, N., Boland, J. W., Featherstone, I., & Johnson, M. J. (in press). Delirium screening practice in specialist palliative care units: A survey. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2020-002251

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Objectives: Delirium is common and distressing in palliative care settings. This survey aims to describe current practice regarding delirium... Read More about Delirium screening practice in specialist palliative care units: A survey.

Practice review: Evidence-based and effective management of pain in patients with advanced cancer (2020)
Journal Article
Chapman, E. J., Edwards, Z., Boland, J. W., Maddocks, M., Fettes, L., Malia, C., …Bennett, M. I. (2020). Practice review: Evidence-based and effective management of pain in patients with advanced cancer. Palliative medicine, 34(4), 444-453. https://doi.org/10.1177/0269216319896955

© The Author(s) 2020. Background: Pain of a moderate or severe intensity affects over half of patients with advanced cancer and remains undertreated in at least one-third of these patients. Aim: The aim of this study was to provide a pragmatic overvi... Read More about Practice review: Evidence-based and effective management of pain in patients with advanced cancer.

Cannabinoids for adult cancer-related pain: systematic review and meta-analysis (2020)
Journal Article
Boland, E. G., Bennett, M. I., Allgar, V., & Boland, J. W. (2020). Cannabinoids for adult cancer-related pain: systematic review and meta-analysis. BMJ supportive & palliative care, 10(1), 14-24. https://doi.org/10.1136/bmjspcare-2019-002032

Objectives There is increased interest in cannabinoids for cancer pain management and legislative changes are in progress in many countries. This study aims to determine the beneficial and adverse effects of cannabis/cannabinoids compared with plac... Read More about Cannabinoids for adult cancer-related pain: systematic review and meta-analysis.

The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review (2019)
Journal Article
Pask, S., Dell’Olio, M., Murtagh, F. E., & Boland, J. W. (2020). The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review. Journal of pain and symptom management, 59(4), 871-893. https://doi.org/10.1016/j.jpainsymman.2019.10.022

Context Opioids are prescribed to manage moderate to severe pain and can be used with older adults; however, they may lead to several adverse effects, including cognitive impairment. Objective To identify, appraise and synthesise evidence on i)... Read More about The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review.

Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies (2019)
Journal Article
Buture, A., Boland, J. W., Dikomitis, L., & Ahmed, F. (2019). Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies. Journal of Pain Research, 12, 269-281. https://doi.org/10.2147/JPR.S175312

Objective: Cluster headache (CH) is the most severe primary headache condition. Its pathophysiology is multifaceted and incompletely understood. This review brings together the latest neuroimaging and neuropeptide evidence on the pathophysiology of C... Read More about Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies.

Identifying potentially inappropriate prescribing in older people with dementia: a systematic review (2019)
Journal Article
Hukins, D., Macleod, U., & Boland, J. W. (2019). Identifying potentially inappropriate prescribing in older people with dementia: a systematic review. European Journal of Clinical Pharmacology, 75(4), 467-481. https://doi.org/10.1007/s00228-018-02612-x

Purpose: Older people with dementia are at risk of adverse events associated with potentially inappropriate prescribing. Aim: to describe (1) how international tools designed to identify potentially inappropriate prescribing have been used in studies... Read More about Identifying potentially inappropriate prescribing in older people with dementia: a systematic review.

The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review (2018)
Journal Article
Ferreira, D. H., Boland, J. W., Phillips, J. L., Lam, L., & Currow, D. C. (2018). The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review. Palliative medicine, 32(4), 786-803. https://doi.org/10.1177/0269216317746583

Background: Driving cessation is associated with poor health-related outcomes. People with chronic diseases are often prescribed long-term opioid agonists that have the potential to impair driving. Studies evaluating the impact of opioids on driving-... Read More about The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review.

Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review (2016)
Journal Article
Obita, G. P., Boland, E. G., Currow, D. C., Johnson, M. J., & Boland, J. W. (2016). Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. Journal of pain and symptom management, 52(6), 901-919. https://doi.org/10.1016/j.jpainsymman.2016.05.032

Context Somatostatin analogues are commonly used to relieve symptoms in malignant bowel obstruction (MBO) but are more expensive than other antisecretory agents. Objectives To evaluate the evidence of effectiveness of somatostatin analogues compared... Read More about Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review.

Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? : a systematic literature review (2015)
Journal Article
Boland, J. W., Ziegler, L., Boland, E. G., McDermid, K., & Bennett, M. I. (2015). Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? : a systematic literature review. Pain, 156(11), 2152-2163. https://doi.org/10.1097/j.pain.0000000000000306

© 2015 International Association for the Study of Pain. Opioids are important in the management of pain in patients with cancer. Clinicians and patients are sometimes concerned about the effect of opioids on survival, which might decrease opioid pres... Read More about Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? : a systematic literature review.

A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: Implications for palliative care research (2015)
Journal Article
Boland, J., Currow, D. C., Wilcock, A., Tieman, J., Hussain, J. A., Pitsillides, C., …Johnson, M. J. (2015). A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: Implications for palliative care research. Journal of pain and symptom management, 49(4), 762-772. https://doi.org/10.1016/j.jpainsymman.2014.09.018

© 2015 American Academy of Hospice and Palliative Medicine. Context The challenges of palliative care clinical trial recruitment are well documented. Objectives The aim of the study was to review tested strategies to improve recruitment to trials of... Read More about A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: Implications for palliative care research.

Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review (2014)
Journal Article
Boland, J. W., McWilliams, K., Ahmedzai, S. H., & Pockley, A. G. (2014). Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review. The British Journal of Cancer, 111(5), 866-873. https://doi.org/10.1038/bjc.2014.384

Background: The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management o... Read More about Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: A systematic literature review.

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