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All Outputs (23)

Insights into the pathological basis of dementia from population-based neuropathology studies (2023)
Journal Article
Wharton, S. B., Simpson, J. E., Ince, P. G., Richardson, C. D., Merrick, R., Matthews, F. E., & Brayne, C. (2023). Insights into the pathological basis of dementia from population-based neuropathology studies. Neuropathology and Applied Neurobiology, 49(4), Article e12923. https://doi.org/10.1111/nan.12923

The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complement... Read More about Insights into the pathological basis of dementia from population-based neuropathology studies.

Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis (2023)
Journal Article
Huque, H., Eramudugolla, R., Chidiac, B., Ee, N., Ehrenfeld, L., Matthews, F. E., …Anstey, K. J. (2023). Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease, 91(4), 1231-1241. https://doi.org/10.3233/JAD-220724

Background: Despite rising interest in sex differences in dementia, it is unclear whether sex differences in dementia incidence and prevalence are apparent globally. Objective: We examine sex differences in incidence and prevalence of Any dementia, A... Read More about Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis.

What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis (2019)
Journal Article
Stow, D., Spiers, G., Matthews, F. E., & Hanratty, B. (2019). What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis. Palliative medicine, 33(4), 399-414. https://doi.org/10.1177/0269216319828650

Background: The number of older people living and dying with frailty is rising, but our understanding of their end-of-life care needs is limited. Aim: To synthesise evidence on the end-of-life care needs of people with frailty. Design: Systematic rev... Read More about What is the evidence that people with frailty have needs for palliative care at the end of life? A systematic review and narrative synthesis.

Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups (2019)
Journal Article
Perneczky, R., Kempermann, G., Korczyn, A. D., Matthews, F. E., Ikram, M. A., Scarmeas, N., …Ewers, M. (2019). Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups. BMC medicine, 17(1), https://doi.org/10.1186/s12916-019-1283-z

Background: The concept of reserve was established to account for the observation that a given degree of neurodegenerative pathology may result in varying degrees of symptoms in different individuals. There is a large amount of evidence on epidemiolo... Read More about Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups.

Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence (2019)
Journal Article
Spiers, G., Matthews, F. E., Moffatt, S., Barker, R., Jarvis, H., Stow, D., …Hanratty, B. (2019). Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence. Health and Social Care in the Community, 27(5), e651-e662. https://doi.org/10.1111/hsc.12798

Improving our understanding of the complex relationship between health and social care utilisation is vital as populations age. This systematic review aimed to synthesise evidence on the relationship between older adults’ use of social care and their... Read More about Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence.

Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis (2019)
Journal Article
Spiers, G., Matthews, F. E., Moffatt, S., Barker, R. O., Jarvis, H., Stow, D., …Hanratty, B. (2019). Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis. Age and ageing, 48(1), 57-66. https://doi.org/10.1093/ageing/afy147

Objective to investigate the impact of the availability and supply of social care on healthcare utilisation (HCU) by older adults in high income countries. Design systematic review and meta-analysis. Data sources medline, EMBASE, Scopus, Health Manag... Read More about Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis.

Dying comfortably in very old age with or without dementia in different care settings - A representative "older old" population study (2017)
Journal Article
Fleming, J., Calloway, R., Perrels, A., Farquhar, M., Barclay, S., Brayne, C., …Zhao, E. (2017). Dying comfortably in very old age with or without dementia in different care settings - A representative "older old" population study. BMC Geriatrics, 17(1), https://doi.org/10.1186/s12877-017-0605-2

Background: Comfort is frequently ranked important for a good death. Although rising numbers of people are dying in very old age, many with dementia, little is known about symptom control for "older old" people or whether care in different settings e... Read More about Dying comfortably in very old age with or without dementia in different care settings - A representative "older old" population study.

The changing prevalence and incidence of dementia over time-current evidence (2017)
Journal Article
Wu, Y. T., Beiser, A. S., Breteler, M. M., Fratiglioni, L., Helmer, C., Hendrie, H. C., …Brayne, C. (2017). The changing prevalence and incidence of dementia over time-current evidence. Nature Reviews Neurology, 13(6), 327-339. https://doi.org/10.1038/nrneurol.2017.63

Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary researchers. The most recent descriptive epidemiological research into dementia is enabling investigation into how the prevalence and incidence are changing o... Read More about The changing prevalence and incidence of dementia over time-current evidence.

Dementia in western Europe: Epidemiological evidence and implications for policy making (2016)
Journal Article
Wu, Y. T., Fratiglioni, L., Matthews, F. E., Lobo, A., Breteler, M. M., Skoog, I., & Brayne, C. (2016). Dementia in western Europe: Epidemiological evidence and implications for policy making. Lancet Neurology, 15(1), 116-124. https://doi.org/10.1016/S1474-4422%2815%2900092-7

Dementia is receiving increasing attention from governments and politicians. Epidemiological research based on western European populations done 20 years ago provided key initial evidence for dementia policy making, but these estimates are now out of... Read More about Dementia in western Europe: Epidemiological evidence and implications for policy making.

Prevalence of dementia in East Asia: A synthetic review of time trends (2015)
Journal Article
Wu, Y. T., Brayne, C., & Matthews, F. E. (2015). Prevalence of dementia in East Asia: A synthetic review of time trends. International journal of geriatric psychiatry, 30(8), 793-801. https://doi.org/10.1002/gps.4297

Objective This study aims to synthesise evidence on time trends of dementia prevalence in East Asian countries including Japan, China, South Korea and Taiwan and assess the impact of the societal changes on future prevalence. Method Relevant reviews... Read More about Prevalence of dementia in East Asia: A synthetic review of time trends.

Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis (2014)
Journal Article
Wu, Y. T., Lee, H. Y., Norton, S., Prina, A. M., Fleming, J., Matthews, F. E., & Brayne, C. (2014). Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis. International journal of geriatric psychiatry, 29(12), 1212-1220. https://doi.org/10.1002/gps.4148

Objective: There have been dramatic societal changes in East Asia over the last hundred years. Several of the established risk factors could have important period and cohort effects. This study explores temporal variation of dementia prevalence in ma... Read More about Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis.

Grouping of behavioural and psychological symptoms of dementia (2014)
Journal Article
Van Der Linde, R. M., Dening, T., Matthews, F. E., & Brayne, C. (2014). Grouping of behavioural and psychological symptoms of dementia. International journal of geriatric psychiatry, 29(6), 562-568. https://doi.org/10.1002/gps.4037

Objective A wide range of behavioural and psychological symptoms (BPSD) are common in dementia, and it has been suggested that groups of correlated symptoms should be studied together. Here, we describe the groups of BPSD that have been identified in... Read More about Grouping of behavioural and psychological symptoms of dementia.

Dementia: Time trends and policy responses (2014)
Journal Article
Wu, Y. T., Matthews, F. E., & Brayne, C. (2014). Dementia: Time trends and policy responses. Maturitas, 79(2), 191-195. https://doi.org/10.1016/j.maturitas.2014.06.020

In recent years, dementia has been considered a public health priority and become a topic of major political interest. Recent reviews and studies have reported with varying degrees of alarm an impending and existing "dementia epidemic" with increasin... Read More about Dementia: Time trends and policy responses.

Prevalence of autism in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis (2013)
Journal Article
Sun, X., Allison, C., Matthews, F. E., Sharp, S. J., Auyeung, B., Baron-Cohen, S., & Brayne, C. (2013). Prevalence of autism in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis. Molecular Autism, 4(1), https://doi.org/10.1186/2040-2392-4-7

Background: The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the prevalence of ASC in these areas and... Read More about Prevalence of autism in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis.

A commentary on studies presenting projections of the future prevalence of dementia (2013)
Journal Article
Norton, S., Matthews, F. E., & Brayne, C. (2013). A commentary on studies presenting projections of the future prevalence of dementia. BMC public health, 13(1), https://doi.org/10.1186/1471-2458-13-1

Background: Population ageing over the first half of this century is likely to lead to dramatic increases in the prevalence of dementia. This will affect all regions of the world, but particularly developing regions. Dementia projections have been us... Read More about A commentary on studies presenting projections of the future prevalence of dementia.

The neuropathological profile of mild cognitive impairment (MCI): A systematic review (2012)
Journal Article
Stephan, B. C., Hunter, S., Harris, D., Llewellyn, D. J., Siervo, M., Matthews, F. E., & Brayne, C. (2012). The neuropathological profile of mild cognitive impairment (MCI): A systematic review. Molecular Psychiatry, 17(11), 1056-1076. https://doi.org/10.1038/mp.2011.147

Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects an intermediate state between no cognitive impairment and dementia is not clear. Identifying which biological events occur at the earliest stage of progres... Read More about The neuropathological profile of mild cognitive impairment (MCI): A systematic review.

Neuropathological profile of mild cognitive impairment from a population perspective (2012)
Journal Article
Stephan, B. C., Matthews, F. E., Hunter, S., Savva, G. M., Bond, J., McKeith, I. G., …Brayne, C. (2012). Neuropathological profile of mild cognitive impairment from a population perspective. Alzheimer Disease and Associated Disorders, 26(3), 205-212. https://doi.org/10.1097/WAD.0b013e31822fc24d

Whether the neuropathological profile of mild cognitive impairment (MCI) reflects an intermediate state between normal aging and dementia is not clear. Identifying which phenomena initiate disease and which occur secondary to the neuropathological pr... Read More about Neuropathological profile of mild cognitive impairment from a population perspective.

Objective measures of physical capability and subsequent health: A systematic review (2011)
Journal Article
Cooper, R., Kuh, D., Cooper, C., Gale, C. R., Lawlor, D. A., Matthews, F., & Hardy, R. (2011). Objective measures of physical capability and subsequent health: A systematic review. Age and ageing, 40(1), 14-23. https://doi.org/10.1093/ageing/afq117

Background: measures of physical capability may be predictive of subsequent health, but existing published studies have not been systematically reviewed. We hypothesised that weaker grip strength, slower walking speed and chair rising and shorter sta... Read More about Objective measures of physical capability and subsequent health: A systematic review.

Dementia risk prediction in the population: Are screening models accurate? (2010)
Journal Article
Stephan, B. C., Kurth, T., Matthews, F. E., Brayne, C., & Dufouil, C. (2010). Dementia risk prediction in the population: Are screening models accurate?. Nature Reviews Neurology, 6(6), 318-326. https://doi.org/10.1038/nrneurol.2010.54

Early identification of individuals at risk of dementia will become crucial when effective preventative strategies for this condition are developed. Various dementia prediction models have been proposed, including clinic-based criteria for mild cogni... Read More about Dementia risk prediction in the population: Are screening models accurate?.