Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2
(2005)
Journal Article
Carroll, V. A., Nikitenko, L. L., Bicknell, R., & Harris, A. L. (2005). Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(4), 736-741. https://doi.org/10.1161/01.ATV.0000157980.15710.2b
Objective - The thrombolytic therapy drug, Reteplase, is a domain deletion mutant of tissue plasminogen activator (tPA), comprising the kringle 2 and protease (K2P) domains. Some kringle domains of hemostatic proteins are antiangiogenic and promote a... Read More about Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2.