All Outputs (15)

Active Cognitive Lifestyle Is Associated with Positive Cognitive Health Transitions and Compression of Morbidity from Age Sixty-Five (2012)
Journal Article
Marioni, R. E., Valenzuela, M. J., van den Hout, A., Brayne, C., & Matthews, F. E. (2012). Active Cognitive Lifestyle Is Associated with Positive Cognitive Health Transitions and Compression of Morbidity from Age Sixty-Five. PLoS ONE, 7(12), https://doi.org/10.1371/journal.pone.0050940

Background: Three factors commonly used as measures of cognitive lifestyle are education, occupation, and social engagement. This study determined the relative importance of each variable to long term cognitive health in those with and without severe... Read More about Active Cognitive Lifestyle Is Associated with Positive Cognitive Health Transitions and Compression of Morbidity from Age Sixty-Five.

The neuropathological profile of mild cognitive impairment (MCI): A systematic review (2012)
Journal Article
Stephan, B. C., Hunter, S., Harris, D., Llewellyn, D. J., Siervo, M., Matthews, F. E., & Brayne, C. (2012). The neuropathological profile of mild cognitive impairment (MCI): A systematic review. Molecular Psychiatry, 17(11), 1056-1076. https://doi.org/10.1038/mp.2011.147

Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects an intermediate state between no cognitive impairment and dementia is not clear. Identifying which biological events occur at the earliest stage of progres... Read More about The neuropathological profile of mild cognitive impairment (MCI): A systematic review.

Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort (2012)
Journal Article
Lace, G., Ince, P. G., Brayne, C., Savva, G. M., Matthews, F. E., De Silva, R., …Wharton, S. B. (2012). Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort. Dementia and Geriatric Cognitive Disorders, 34(1), 15-24. https://doi.org/10.1159/000341581

Background: Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort. Me... Read More about Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.

Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: A population-based prospective cohort study (2012)
Journal Article
Matthews, F., Marioni, R., & Brayne, C. (2012). Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: A population-based prospective cohort study. BMC Geriatrics, 12, https://doi.org/10.1186/1471-2318-12-45

Background: Whilst many studies have analysed predictors of longitudinal cognitive decline, few have described their impact on population distributions of cognition by age cohort. The aim of this paper was to examine whether gender, education, social... Read More about Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: A population-based prospective cohort study.

What sleep characteristics predict cognitive decline in the elderly? (2012)
Journal Article
Keage, H. A. D., Banks, S., Yang, K. L., Morgan, K., Brayne, C., & Matthews, F. E. (2012). What sleep characteristics predict cognitive decline in the elderly?. Sleep medicine, 13(7), 886-892. https://doi.org/10.1016/j.sleep.2012.02.003

Background: Sleep is critical for optimal cognitive function, but as we age both cognitive impairment and sleep problems increase. Longitudinal, population-based studies can be used to investigate temporal relationships between sleep and cognition. M... Read More about What sleep characteristics predict cognitive decline in the elderly?.

Neuropathological profile of mild cognitive impairment from a population perspective (2012)
Journal Article
Stephan, B. C., Matthews, F. E., Hunter, S., Savva, G. M., Bond, J., McKeith, I. G., …Brayne, C. (2012). Neuropathological profile of mild cognitive impairment from a population perspective. Alzheimer Disease and Associated Disorders, 26(3), 205-212. https://doi.org/10.1097/WAD.0b013e31822fc24d

Whether the neuropathological profile of mild cognitive impairment (MCI) reflects an intermediate state between normal aging and dementia is not clear. Identifying which phenomena initiate disease and which occur secondary to the neuropathological pr... Read More about Neuropathological profile of mild cognitive impairment from a population perspective.

Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands (2012)
Journal Article
Roelfsema, M. T., Hoekstra, R. A., Allison, C., Wheelwright, S., Brayne, C., Matthews, F. E., & Baron-Cohen, S. (2012). Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands. Journal of Autism and Developmental Disorders, 42(5), 734-739. https://doi.org/10.1007/s10803-011-1302-1

We tested for differences in the prevalence of autism spectrum conditions (ASC) in school-aged children in three geographical regions in the Netherlands. Schools were asked to provide the number of children enrolled, the number having a clinical diag... Read More about Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands.

Multiple biological pathways link cognitive lifestyle to protection from dementia (2012)
Journal Article
Valenzuela, M. J., Matthews, F. E., Brayne, C., Ince, P., Halliday, G., Kril, J. J., …Sachdev, P. S. (2012). Multiple biological pathways link cognitive lifestyle to protection from dementia. Biological Psychiatry, 71(9), 783-791. https://doi.org/10.1016/j.biopsych.2011.07.036

Background: An active cognitive lifestyle is linked to diminished dementia risk, but the underlying mechanisms are poorly understood. Potential mechanisms include disease modification, neuroprotection, and compensation. Prospective, population-based... Read More about Multiple biological pathways link cognitive lifestyle to protection from dementia.

Population heterogeneity in trajectories of midlife blood pressure (2012)
Journal Article
Wills, A. K., Lawlor, D. A., Muniz-Terrera, G., Matthews, F., Cooper, R., Ghosh, A. K., …Hardy, R. (2012). Population heterogeneity in trajectories of midlife blood pressure. Epidemiology, 23(2), 203-211. https://doi.org/10.1097/EDE.0b013e3182456567

Background: We investigated whether there are subgroups with different underlying (latent) trajectories of midlife systolic blood pressure (BP), diastolic BP, and pulse pressure in a UK cohort. Methods: Data are from 1840 men and 1819 women with BP m... Read More about Population heterogeneity in trajectories of midlife blood pressure.

Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study (2012)
Journal Article
Davis, D. H., Muniz Terrera, G., Keage, H., Rahkonen, T., Oinas, M., Matthews, F. E., …Brayne, C. (2012). Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study. Brain, 135(9), 2809-2816. https://doi.org/10.1093/brain/aws190

Recent studies suggest that delirium is associated with risk of dementia and also acceleration of decline in existing dementia. However, previous studies may have been confounded by incomplete ascertainment of cognitive status at baseline. Herein, we... Read More about Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study.

The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS) (2012)
Journal Article
Richardson, K., Stephan, B. C., Ince, P. G., Brayne, C., Matthews, F. E., & Esiri, M. M. (2012). The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS). Current Alzheimer Research, 9(6), 687-696. https://doi.org/10.2174/156720512801322654

Background: Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. Methods: Brain donations to the population-base... Read More about The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS).

Neuropathological correlates of falling in the CC75C population-based ample of the older old (2012)
Journal Article
Richardson, K., Hunter, S., Dening, T., Xuereb, J. H., Matthews, F. E., Brayne, C., …Paykel, E. (2012). Neuropathological correlates of falling in the CC75C population-based ample of the older old. Current Alzheimer Research, 9(6), 697-708. https://doi.org/10.2174/156720512801322636

Background: Previous imaging studies have suggested links between brain pathologies and factors that are associated with falls such as gait, balance and daily function. Possible neuropathological correlates of older people's falls have been suggested... Read More about Neuropathological correlates of falling in the CC75C population-based ample of the older old.

Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample (2012)
Journal Article
Stephan, B. C., Matthews, F. E., Ma, B., Muniz, G., Hunter, S., Davis, D., …Brayne, C. (2012). Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample. Journal of Alzheimer's Disease, 29(2), 309-318. https://doi.org/10.3233/JAD-2011-110518

The state between aging with no cognitive impairment and dementia has become a major focus for intervention. The neuropathological and neurobiological correlates of this intermediate state are therefore of considerable interest, particularly from pop... Read More about Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample.

Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort (2012)
Journal Article
Keage, H. A., Ince, P. G., Matthews, F. E., Wharton, S. B., McKeith, I. G., & Brayne, C. (2012). Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort. Journal of Alzheimer's Disease, 28(2), 485-493. https://doi.org/10.3233/JAD-2011-111268

Epidemiological studies investigating the pathological bases of late onset dementia focus on classical markers such as plaques and tangles. The significance of pathologies characteristically associated with rare dementia syndromes such as Pick bodies... Read More about Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort.

Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline (2012)
Journal Article
Marioni, R. E., Van Den Hout, A., Valenzuela, M. J., Brayne, C., & Matthews, F. E. (2012). Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline. Journal of Alzheimer's Disease, 28(1), 223-230. https://doi.org/10.3233/JAD-2011-110377

Education and lifestyle factors linked with complex mental activity are thought to affect the progression of cognitive decline. Collectively, these factors can be combined to create a cognitive reserve or cognitive lifestyle score. This study tested... Read More about Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline.