All Outputs (886)

How can NHS trusts in England optimise strategies to improve the mental health and well-being of hospital doctors? The Care Under Pressure 3 (CUP3) realist evaluation study protocol (2023)
Journal Article
Bramwell, C., Carrieri, D., Melvin, A., Pearson, A., Scott, J., Hancock, J., …Mattick, K. (2023). How can NHS trusts in England optimise strategies to improve the mental health and well-being of hospital doctors? The Care Under Pressure 3 (CUP3) realist evaluation study protocol. BMJ open, 13(11), Article e073615. https://doi.org/10.1136/bmjopen-2023-073615

INTRODUCTION: The growing incidence of mental ill health in doctors was a major issue in the UK and internationally, even prior to the COVID-19 pandemic. It has significant and far-reaching implications, including poor quality or inconsistent patient... Read More about How can NHS trusts in England optimise strategies to improve the mental health and well-being of hospital doctors? The Care Under Pressure 3 (CUP3) realist evaluation study protocol.

Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets (2023)
Journal Article
Gil, H. M., Booth, Z., Price, T. W., Lee, J., Naylor‐Adamson, L., Avery, M., …Stasiuk, G. J. (in press). Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets. Small, Article 2304881. https://doi.org/10.1002/smll.202304881

InP/ZnS quantum dots (QDs) have received a large focus in recent years as a safer alternative to heavy metal-based QDs. Given their intrinsic fluorescent imaging capabilities, these QDs can be potentially relevant for in vivo platelet imaging. The In... Read More about Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets.

Euler-Euler LES of bubble column bubbly flows by considering sub-grid scale turbulent dispersion effect on modulating bubble transport (2023)
Journal Article
Long, S., Yang, X., Yang, J., Li, B., Shi, W., & Sommerfeld, M. (2023). Euler-Euler LES of bubble column bubbly flows by considering sub-grid scale turbulent dispersion effect on modulating bubble transport. Chemical Engineering Journal, 477, Article 147239. https://doi.org/10.1016/j.cej.2023.147239

It has now been recognised and generally accepted that turbulent dispersion may be modelled using the time average of the fluctuating part of the interphase momentum, employing the drag the Favre averaged drag model for turbulent dispersion in Euleri... Read More about Euler-Euler LES of bubble column bubbly flows by considering sub-grid scale turbulent dispersion effect on modulating bubble transport.

Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial (2023)
Journal Article
Santos-Ferreira, D., Diaz, S. O., Ferreira, J. P., Girerd, N., Pellicori, P., Mariottoni, B., …Zannad, F. (2024). Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial. ESC Heart Failure, 11(1), 209-218. https://doi.org/10.1002/ehf2.14465

Aims: We aim to characterize the clinical and proteomic profiles of patients at risk of developing heart failure (HF), with and without coronary artery disease (CAD) or prior myocardial infarction (MI). Methods and results: HOMAGE evaluated the effec... Read More about Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial.

Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions (2023)
Journal Article
Molica, S., Tam, C., Allsup, D., & Polliack, A. (in press). Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions. Hematological Oncology, https://doi.org/10.1002/hon.3238

In the modern era of Chronic Lymphocytic Leukemia (CLL) targeted therapy, the loss of p53 function due to genetic abnormalities remains a significant challenge. This is because even targeted agents, which are currently the mainstay of treatment for C... Read More about Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions.

'Not quickly cleansed' Bids for Freedom by Former Slaves in Mombasa and the Coastal Strip of Kenya (2023)
Thesis
Farah, F. (2023). 'Not quickly cleansed' Bids for Freedom by Former Slaves in Mombasa and the Coastal Strip of Kenya. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4571172

My research deals with slavery and its legacies in Mombasa, Kenya. The ethnic tensions that exist today in Mombasa have their roots in two historical legacies, slavery and colonialism. Seeds of inequalities planted during those two periods still dict... Read More about 'Not quickly cleansed' Bids for Freedom by Former Slaves in Mombasa and the Coastal Strip of Kenya.

The physiological and behavioural responses of the shore crab Carcinus meanas (L) to near-future levels of ocean acidification. (2023)
Thesis
Monaghan, A. (2023). The physiological and behavioural responses of the shore crab Carcinus meanas (L) to near-future levels of ocean acidification. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4564060

Ocean acidification as a result of increased anthropogenic Carbon Dioxide is a widely documented threat to marine life as a whole. According to current predictions, ocean pH is set to continue its hereto unprecedented level of decrease throughout the... Read More about The physiological and behavioural responses of the shore crab Carcinus meanas (L) to near-future levels of ocean acidification..

The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance (2023)
Journal Article
Mahmoudi-Aznaveh, A., Tavoosidana, G., Najmabadi, H., Azizi, Z., & Ardestani, A. (2023). The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance. Frontiers in endocrinology, 14, Article 1303930. https://doi.org/10.3389/fendo.2023.1303930

Introduction: An insufficient functional beta cell mass is a core pathological hallmark of type 2 diabetes (T2D). Despite the availability of several effective pharmaceuticals for diabetes management, there is an urgent need for novel medications to... Read More about The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance.

From textile waste to carbon nanomaterials for offshore wind turbine blades (2023)
Thesis
Marsden, H. (2023). From textile waste to carbon nanomaterials for offshore wind turbine blades. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4459343

The aim of this research was to determine the feasibility of carbon production from the pyrolysis of textile waste, seeking a way of increasing the sustainability of “fast fashion” and recycling the 92 million tonnes of textile waste entering landfil... Read More about From textile waste to carbon nanomaterials for offshore wind turbine blades.

Women’s football subculture of misogyny: the escalation to online gender-based violence (2023)
Journal Article
Fenton, A., Ahmed, W., Hardey, M., Boardman, R., & Kavanagh, E. (in press). Women’s football subculture of misogyny: the escalation to online gender-based violence. European Sport Management Quarterly, https://doi.org/10.1080/16184742.2023.2270566

Research question Given the worldwide growth of women’s football and its presence on social media, it is essential to explore and understand fan attitudes and culture. Research methods This article provides the first empirical social media netnogr... Read More about Women’s football subculture of misogyny: the escalation to online gender-based violence.

The role of WSB-1 as a BRCAness biomarker in breast cancer (2023)
Thesis
Li, . C. (2023). The role of WSB-1 as a BRCAness biomarker in breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4436228

Background Radiotherapy currently has become one of the major therapeutic approaches in the treatments for cancers. However, hypoxia presents a significant challenge to the effectiveness of radiotherapy and is associated with radio-resistance. Previ... Read More about The role of WSB-1 as a BRCAness biomarker in breast cancer.

Sleep disturbance in dementia or mild cognitive impairment: a realist review of general practice (2023)
Journal Article
Aryankhesal, A., Blake, J., Wong, G., Megson, M., Briscoe, S., Allan, L., Broomfield, N., Eastwood, Z., Greene, L., Hilton, A., Killett, A., Lazar, A., Litherland, R., Livingston, G., Maidment, I., Reeve, J., Rook, G., Scott, S., Un, J., van Horik, J., & Fox, C. (online). Sleep disturbance in dementia or mild cognitive impairment: a realist review of general practice. The British journal of general practice : the journal of the Royal College of General Practitioners, https://doi.org/10.3399/BJGP.2023.0171

Background Sleep disturbance (SD) is a prevalent condition among people living with dementia (PLwD) or mild cognitive impairment (MCI). Its assessment and management within primary care is complex due to the comorbidities, older age and cognitive im... Read More about Sleep disturbance in dementia or mild cognitive impairment: a realist review of general practice.

Conscience in Marvell (2023)
Book Chapter
Mottram, S. (in press). Conscience in Marvell. In A. Hadfield, & P. Hammond (Eds.), Words at War: The Contested Language of the English Civil War (237-50). Oxford University Press

Andrew Marvell today enjoys a reputation as a Restoration champion of religious freedom, but this reputation can seem out of step with Marvell’s more outspoken attacks on protestant sects in his Commonwealth poems, and with his ambivalent approach, i... Read More about Conscience in Marvell.

The black widow pulsar J1641+8049 in the optical, radio, and X-rays (2023)
Journal Article
Kirichenko, A. Y., Zharikov, S. V., Karpova, A. V., Fonseca, E., Zyuzin, D. A., Shibanov, Y. A., …Swiggum, J. K. (2024). The black widow pulsar J1641+8049 in the optical, radio, and X-rays. Monthly notices of the Royal Astronomical Society, 527(3), 4563-4572. https://doi.org/10.1093/mnras/stad3391

PSR J1641+8049 is a 2 ms black widow pulsar with the 2.2 h orbital period detected in the radio and γ -rays. We performed new phase-resolved multiband photometry of PSR J1641+8049 using the OSIRIS instrument at the Gran Telescopio Canarias. The obtai... Read More about The black widow pulsar J1641+8049 in the optical, radio, and X-rays.

Improved traceability in seafood supply chains is achievable by minimising vulnerable nodes in processing and distribution networks (2023)
Journal Article
Hopkins, C. R., Roberts, S. I., Caveen, A. J., Graham, C., & Burns, N. M. (2024). Improved traceability in seafood supply chains is achievable by minimising vulnerable nodes in processing and distribution networks. Marine Policy, 159, Article 105910. https://doi.org/10.1016/j.marpol.2023.105910

Seafood is a globally traded commodity, often involving complex supply chains which have varying degrees of traceability. A robust traceability system for seafood supply chains enables the collection and communication of key information about catch a... Read More about Improved traceability in seafood supply chains is achievable by minimising vulnerable nodes in processing and distribution networks.

Molecular Analysis at Relapse of Patients Treated on the Ibrutinib and Rituximab Arm of the National Multi-Centre Phase III FLAIR Study in Previously Untreated CLL Patients (2023)
Presentation / Conference Contribution
Sarma, A., Evans, C., Dalal, S., Webster, N., Rawstron, A., Shingles, J., …Hillmen, P. (2023). Molecular Analysis at Relapse of Patients Treated on the Ibrutinib and Rituximab Arm of the National Multi-Centre Phase III FLAIR Study in Previously Untreated CLL Patients. Blood, 142(Supplement 1), 4636-4636. https://doi.org/10.1182/blood-2023-188597

Using Peripheral Blood (PB) Measurable Residual Disease (MRD) Levels to Predict <0.01% Bone Marrow Disease (BM uMRD4): Identification of Effective PB Targets for CLL Treatment Cessation in the Ibrutinib+Venetoclax Arm of the FLAIR Trial (2023)
Presentation / Conference Contribution
Rawstron, A., Webster, N., Dalal, S., de Tute, R. M., Bell, S., Cairns, D. A., Girvan, S., Greatorex, N., Hockaday, A., Jackson, S., Phillips, D., Stones, D., Allsup, D., Bloor, A. J. C., Sarma, A., Varghese, A. M., Munir, T., & Hillmen, P. Using Peripheral Blood (PB) Measurable Residual Disease (MRD) Levels to Predict <0.01% Bone Marrow Disease (BM uMRD4): Identification of Effective PB Targets for CLL Treatment Cessation in the Ibrutinib+Venetoclax Arm of the FLAIR Trial. Presented at 65th ASH Annual Meeting and Exposition, San Diego, CA

Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study (2023)
Presentation / Conference Contribution
Hillmen, P., Cairns, D. A., Bloor, A. J. C., Allsup, D., Cwynarski, K., Pettitt, A., Paneesha, S., Fox, C. P., Eyre, T. A., Forconi, F., Elmusharaf, N., Kennedy, B., Gribben, J. G., Pemberton, N., Sheehy, O., Preston, G., Schuh, A., Howard, D., Hockaday, A., Jackson, S., …Munir, T. Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study. Presented at 65th ASH Annual Meeting and Exposition, San Diego, CA

Introduction: Ibrutinib (I), an irreversible Btk inhibitor, and venetoclax (V), a Bcl-2 inhibitor, improve CLL outcomes in trials compared to chemoimmunotherapy. I and V target two key pathophysiological pathways in CLL and should be synergistic. Thi... Read More about Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study.

Characterisation of Novel and High Performing Double-Sided Microporous-Layers-Coated Gas Diffusion Layers for Polymer Electrolyte Membrane Fuel Cells (2023)
Journal Article
Ruscillo, F., Zhang, K., Ismail, M. S., Hughes, K. J., Ingham, D. B., Ma, L., & Pourkashanian, M. (2023). Characterisation of Novel and High Performing Double-Sided Microporous-Layers-Coated Gas Diffusion Layers for Polymer Electrolyte Membrane Fuel Cells. Energies, 16(22), Article 7601. https://doi.org/10.3390/en16227601

This study aims to experimentally evaluate the impact of a double-sided microporous layer coating on gas diffusion layers in terms of their key properties and fuel cell performance, in comparison to conventional single-sided coated gas diffusion laye... Read More about Characterisation of Novel and High Performing Double-Sided Microporous-Layers-Coated Gas Diffusion Layers for Polymer Electrolyte Membrane Fuel Cells.

BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping (2023)
Journal Article
Clark, J., Salins, N., Pearson, M., Spathis, A., Currow, D. C., Williams, S., & Johnson, M. (2023). BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping. PLoS ONE, 18(11 November), Article e0293918. https://doi.org/10.1371/journal.pone.0293918

Background Breathlessness that persists despite treatment of causal disease(s) is disabling, associated with high therapy-related costs and poor socioeconomic outcomes. Low resource countries bear a disproportionate burden of respiratory problems, of... Read More about BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping.