Dr Francisco Rivero Crespo's Outputs (7)

An investigation into the TRPV1-CGRP signalling pathway in vessel development (2024)
Thesis
Bates, A. An investigation into the TRPV1-CGRP signalling pathway in vessel development. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4865918

TRPV1 is a non-selective cation channel which is activated through various different factors including, but not limited to, raised temperature and acidic pH. It has been linked in the past to endothelial cell proliferation in acidic conditions, but a... Read More about An investigation into the TRPV1-CGRP signalling pathway in vessel development.

Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system (2023)
Thesis
Saldanha, P. A. C. B. D. S. Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4790706

Regulation of actomyosin-driven contraction is important for numerous cardiovascular cell functions, including smooth muscle tone, endothelial cell permeability and platelet shape change and spreading. These processes are primarily regulated by the p... Read More about Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system.

Platelets as components of the circulating immune system : role as scavenging cells (2020)
Thesis
Chacko, A. R. (2020). Platelets as components of the circulating immune system : role as scavenging cells. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4222993

Although platelets are widely known for their role in haemostasis, an increasing body of evidence demonstrates platelets to encompass a role as immune cells. This underappreciated function involves numerous cell surface receptors and a series of intr... Read More about Platelets as components of the circulating immune system : role as scavenging cells.

Investigation of the roles of the actin cytoskeleton remodelling proteins coronin and CAP1 in platelet function (2020)
Thesis
Riley, D. R. J. (2020). Investigation of the roles of the actin cytoskeleton remodelling proteins coronin and CAP1 in platelet function. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4223044

Platelets undergo profound rapid F-actin cytoskeleton remodeling and experience morphological and functional changes in response to receptor-mediated signaling from damaged blood vessel walls. The evolutionarily conserved proteins coronin 1 and adeny... Read More about Investigation of the roles of the actin cytoskeleton remodelling proteins coronin and CAP1 in platelet function.

A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets (2018)
Thesis
Khalil, J. S. (2018). A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221504

Platelet activation initiates a series of events, such as shape change, degranulation and aggregation, which results in the formation of a haemostatic plug and arrest of blood loss at the sites of vascular damage. Shape change is accompanied by remod... Read More about A novel interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in platelets.

Effects of resistin on platelet function and its receptor, adenylyl cyclase associated protein 1 (2017)
Thesis
Joshi, P. L. (2017). Effects of resistin on platelet function and its receptor, adenylyl cyclase associated protein 1. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221793

Resistin is an adipokine which is found elevated in patients suffering from metabolic syndrome, affecting a large proportion of the population. It is characterised by obesity, insulin resistance (IR), type 2 diabetes mellitus (T2DM) and cardiovascula... Read More about Effects of resistin on platelet function and its receptor, adenylyl cyclase associated protein 1.

Characterisation of a RhoBTB3 deficient mouse model (2012)
Thesis
Lutz, J. B. (2012). Characterisation of a RhoBTB3 deficient mouse model. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4219075

RhoBTB proteins are atypical members of the Rho-family of small GTPases with a characteristic domain architecture: a GTPase-domain is followed by a proline-rich region, a tandem of two BTB domains and a C-terminal region. RhoBTB3 is the most divergen... Read More about Characterisation of a RhoBTB3 deficient mouse model.