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Professor Ron Patton's Outputs (5)

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease (2014)
Journal Article
Ji, B., Genever, P. G., Patton, R. J., & Fagan, M. J. (2014). Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease. International journal for numerical methods in biomedical engineering, 30(11), 1085-1102. https://doi.org/10.1002/cnm.2645

Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM-in... Read More about Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease.

A predator-prey based mathematical model of the bone remodelling cycle: Exploring the relationship between the model parameters and biochemical factors (2014)
Journal Article
Ji, B., Yang, Q., Genever, P. G., Patton, R. J., & Fagan, M. J. (2014). A predator-prey based mathematical model of the bone remodelling cycle: Exploring the relationship between the model parameters and biochemical factors. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228(10), 1035-1042. https://doi.org/10.1177/0954411914554633

© IMechE 2014. Bone remodelling is a vital process which enables bone to repair, renew and optimize itself. Disorders in the bone remodelling process are inevitably manifested in bone-related diseases, such as hypothyroidism, primary hyperparathyroid... Read More about A predator-prey based mathematical model of the bone remodelling cycle: Exploring the relationship between the model parameters and biochemical factors.

The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: A computer simulation (2012)
Journal Article
Jahani, M., Genever, P. G., Patton, R. J., Ahwal, F., & Fagan, M. J. (2012). The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: A computer simulation. Journal of biomechanics, 45(16), 2876-2883. https://doi.org/10.1016/j.jbiomech.2012.08.005

Osteocytes play a critical role in the regulation of bone remodelling by translating strain due to mechanical loading into biochemical signals transmitted through the interconnecting lacuno-canalicular network to bone lining cells (BLCs) on the bone... Read More about The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: A computer simulation.

A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level (2012)
Journal Article
Ji, B., Genever, P. G., Patton, R. J., Putra, D., & Fagan, M. J. (2012). A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level. Biomechanics and Modeling in Mechanobiology, 11(7), 973-982. https://doi.org/10.1007/s10237-011-0366-3

After an initial phase of growth and development, bone undergoes a continuous cycle of repair, renewal and optimisation by a process called remodelling. This paper describes a novel mathematical model of the trabecular bone remodelling cycle. It is e... Read More about A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level.