Outputs (198)

Crystal structures of two cross-bridged chromium(III) tetraazamacrocycles (2014)
Journal Article
Prior, T. J., Maples, D. L., Maples, R. D., Hoffert, W. A., Parsell, T. H., Silversides, J. D., Archibald, S. J., & Hubin, T. J. (2014). Crystal structures of two cross-bridged chromium(III) tetraazamacrocycles. Acta Crystallographica Section E: Crystallographic Communications, 70(9), 148-152. https://doi.org/10.1107/S1600536814019072

The crystal structure of dichlorido(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane)chromium(III) hexafluoridophosphate, [CrCl 2 (C 12 H 26 N 4 )]PF 6 , (I), has monoclinic symmetry (space group P21/n) at 150 K. The structure of the related... Read More about Crystal structures of two cross-bridged chromium(III) tetraazamacrocycles.

Antibody radiolabeling techniques to optimize cellular retention (2013)
Journal Article
Archibald, S. J. (2013). Antibody radiolabeling techniques to optimize cellular retention. Journal of medicinal chemistry, 56(23), 9415-9417. https://doi.org/10.1021/jm401794v

Radiolabeling of antibodies and antibody fragments facilitates the development of new targeted therapeutics or tracking and validation of biosimilars. The typical metal ion chelators that can be used for radiolabeling reactions have residualizing pro... Read More about Antibody radiolabeling techniques to optimize cellular retention.

Protein-Binding Metal Complexes: Noncovalent and Coordinative Interactions (2013)
Book Chapter
Archibald, S. J., & Smith, R. (2013). Protein-Binding Metal Complexes: Noncovalent and Coordinative Interactions. In Comprehensive Inorganic Chemistry II (Second Edition): From Elements to Applications (661-682). https://doi.org/10.1016/B978-0-08-097774-4.00327-2

Metal ions bind to proteins via coordinate bond formation with amino acid side chains. The use of metal complexes allows formation of targeted protein-bound adducts that show binding via coordination or noncovalent interactions. The retained ligands... Read More about Protein-Binding Metal Complexes: Noncovalent and Coordinative Interactions.

Rapid synthesis of cross-bridged cyclam chelators for copper(II) complex formation (2013)
Journal Article
Silversides, J. D., Burke, B. P., & Archibald, S. J. (2013). Rapid synthesis of cross-bridged cyclam chelators for copper(II) complex formation. Comptes rendus. Chimie, 16(6), 524-530. https://doi.org/10.1016/j.crci.2013.02.013

Copper(II) complexes of 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (cross-bridged cyclam) derived chelators show high kinetic stability relative to less rigid non-bridged azamacrocyclic chelators and have applications as radiopharmaceuticals in PET im... Read More about Rapid synthesis of cross-bridged cyclam chelators for copper(II) complex formation.

Copper complexation of macrocyclic molecules: Towards on-chip radiometallic labelling of PET radiotracers (2013)
Presentation / Conference Contribution
Tarn, M. D., Lu, B., Smith, R., Burke, B. P., Archibald, S. J., & Pamrae, N. Copper complexation of macrocyclic molecules: Towards on-chip radiometallic labelling of PET radiotracers. Presented at 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

We present the use of microfluidic devices for copper(II) ion complexation of cyclen and cyclam macrocycles. Onchip monitoring of the complexation reactions was achieved via absorbance detection. This work opens the door for the on-chip synthesis of... Read More about Copper complexation of macrocyclic molecules: Towards on-chip radiometallic labelling of PET radiotracers.

[4-(Bromomethyl)benzyl]triphenylphosphonium bromide acetonitrile monosolvate (2012)
Journal Article
Burke, B. P., Greenman, P., Smith, A. M., & Archibald, S. J. (2012). [4-(Bromomethyl)benzyl]triphenylphosphonium bromide acetonitrile monosolvate. Acta Crystallographica Section E: Crystallographic Communications, 68(11), https://doi.org/10.1107/S1600536812042341

In the title compound, C 26 H 2 3BrP + · Br - ·C 2 H 3 N, the dihedral angles between the plane of the benzylic phenyl ring attached to the P atom and the planes of the three directly attached phenyl rings are 34.04(12), 45.48(13) and 87.18(9)°. In t... Read More about [4-(Bromomethyl)benzyl]triphenylphosphonium bromide acetonitrile monosolvate.

Small molecule CXCR4 chemokine receptor antagonists: Developing drug candidates (2007)
Journal Article
Khan, A., Greenman, J., & Archibald, S. J. (2007). Small molecule CXCR4 chemokine receptor antagonists: Developing drug candidates. Current medicinal chemistry, 14(21), 2257-2277. https://doi.org/10.2174/092986707781696618

Chemokine receptors are a target of growing interest for new therapeutic drugs, as their role in multiple disease states has been demonstrated. The CXCR4/CXCL12 pairing has been implicated in HIV and cancer, as well as chronic inflammatory diseases,... Read More about Small molecule CXCR4 chemokine receptor antagonists: Developing drug candidates.

3,4-Diiodo-2,5-dimethyl-thio-phene (2007)
Journal Article
Cseh, L., Mehl, G. H., Clark, S., & Archibald, S. J. (2007). 3,4-Diiodo-2,5-dimethyl-thio-phene. Acta Crystallographica Section E: Crystallographic Communications, 63(3), https://doi.org/10.1107/S160053680700760X

In the crystal structure of the title compound, C6H6I2S, the molecules pack to form one-dimensional chains connected by inter-molecular S⋯I inter-actions. © International Union of Crystallography 2007.

Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding (2007)
Journal Article
Khan, A., Silversides, J. D., Madden, L., Greenman, J., & Archibald, S. J. (2007). Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding. Chemical communications : Chem comm / the Royal Society of Chemistry, 416-418. https://doi.org/10.1039/b614557d

The copper(ii) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state... Read More about Fluorescent CXCR4 chemokine receptor antagonists: Metal activated binding.

Copper(II) cyclam-based complexes for radiopharmaceutical applications: Synthesis and structural analysis (2007)
Journal Article
Silversides, J. D., Allan, C. C., & Archibald, S. J. (2007). Copper(II) cyclam-based complexes for radiopharmaceutical applications: Synthesis and structural analysis. Dalton Transactions : an international journal of inorganic chemistry, 971-978. https://doi.org/10.1039/b615329a

Two molecular structures of the copper(ii) complex, Cu(H < inf > 2 < /inf > TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate ar... Read More about Copper(II) cyclam-based complexes for radiopharmaceutical applications: Synthesis and structural analysis.

Probing key coordination interactions: Configurationally restricted metal activated CXCR4 antagonists (2007)
Presentation / Conference Contribution
McRobbie, G., Valks, G. C., Empson, C. J., Khan, A., Silversides, J. D., Pannecouque, C., De Clercq, E., Fiddy, S. G., Bridgeman, A. J., Young, N. A., & Archibald, S. J. Probing key coordination interactions: Configurationally restricted metal activated CXCR4 antagonists

The syntheses of configurationally restricted mono- and bis-macrocyclic copper(ii) perchlorate complexes (copper(ii) 5-benzyl-1,5,8,12- tetraazabicyclo[10.2.2]hexadecane and dicopper(ii) 5,5′-[1,4- phenylenebis(methylene)] -bis(1,5,8,12-tetraazabicyc... Read More about Probing key coordination interactions: Configurationally restricted metal activated CXCR4 antagonists.

(N-Benzyl-bis-N′, N′-salicylidene)-cis-1,3,5-triaminocyclohexane copper(ii): A novel catalyst for the aerobic oxidation of benzyl alcohol (2006)
Journal Article
Nairn, A. K., Archibald, S. J., Bhalla, R., Gilbert, B. C., MacLean, E. J., Teat, S. J., & Walton, P. H. (2006). (N-Benzyl-bis-N′, N′-salicylidene)-cis-1,3,5-triaminocyclohexane copper(ii): A novel catalyst for the aerobic oxidation of benzyl alcohol. Dalton Transactions : an international journal of inorganic chemistry, 60(11), 172172-176176. https://doi.org/10.1039/b512296c

Reaction of Cu(BF 4 ) 2 ·6H 2 O with the N 3 O 2 donor ligand H 2 L (where H 2 L = N-benzyl-N′, N′-di-tert-butyl-disalicyl-triaminocyclohexane) results in the formation of a novel Cu II L complex, 1. X-Ray crystallography of 1 shows the Cu II centre... Read More about (N-Benzyl-bis-N′, N′-salicylidene)-cis-1,3,5-triaminocyclohexane copper(ii): A novel catalyst for the aerobic oxidation of benzyl alcohol.

N-(4-Nitrobenzyl)benzene-1,2-diamine (2006)
Journal Article
Silversides, J. D., Sparke, A. E., & Archibald, S. J. (2006). N-(4-Nitrobenzyl)benzene-1,2-diamine. Acta Crystallographica Section E: Crystallographic Communications, 62(12), https://doi.org/10.1107/S1600536806050136

In the crystal structure of the title compound, C 13 H 13 N 3 O 2 , one-dimensional chains of hydrogen-bonded dimers are linked by π-π stacking interactions. © 2006 International Union of Crystallography All rights reserved.

Dichloro(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane)iron(III) hexafluorophosphate (2006)
Journal Article
McClain, J. M., Maples, D. L., Maples, R. D., Matz, D. L., Harris, S. M., Nelson, A. D. L., Silversides, J. D., Archibald, S. J., & Hubin, T. J. (2006). Dichloro(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane)iron(III) hexafluorophosphate. Acta Crystallographica Section C: Crystal Structure Communications, 62(11), https://doi.org/10.1107/S0108270106040765

The title compound, [FeCl 2 (C 12 H 26 N 4 )]PF 6 , is the first mono-nuclear Fe 3+ complex of an ethylene cross-bridged tetraazamacrocycle to be structurally characterized. Comparison with the mononuclear Fe 2+ complex of the same ligand shows th... Read More about Dichloro(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane)iron(III) hexafluorophosphate.

Configurationally restricted bismacrocyclic CXCR4 receptor antagonists (2006)
Journal Article
Valks, G. C., McRobbie, G., Lewis, E. A., Hubin, T. J., Hunter, T. M., Sadler, P. J., Pannecouque, C., De Clercq, E., & Archibald, S. J. (2006). Configurationally restricted bismacrocyclic CXCR4 receptor antagonists. Journal of medicinal chemistry, 49(21), 6162-6165. https://doi.org/10.1021/jm0607810

A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favo... Read More about Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.

Routes to highly substituted thiophenol derivatives (2006)
Journal Article
Nicholson, G., Silversides, J. D., & Archibald, S. J. (2006). Routes to highly substituted thiophenol derivatives. Tetrahedron letters; the international organ for the rapid publication of preliminary communications in organic chemistry, 47(37), 6541-6544. https://doi.org/10.1016/j.tetlet.2006.07.039

Syntheses of highly substituted thiophenol derivatives that incorporate steric bulk into the ligand framework via ortho and para tert-butyl substituents are reported. S-Benzyl and trityl protection were investigated and the effects of substituents on... Read More about Routes to highly substituted thiophenol derivatives.

Syntheses of copper(I) cis-1,3,5-tri-iminocyclohexane complexes (2006)
Journal Article
Nairn, A. K., Archibald, S. J., Bhalla, R., Boxwell, C. J., Whitwood, A. C., & Walton, P. H. (2006). Syntheses of copper(I) cis-1,3,5-tri-iminocyclohexane complexes. Dalton Transactions : an international journal of inorganic chemistry, 6(14), 1790-1795. https://doi.org/10.1039/b510703b

Copper(I) complexes of the ligand cis-1,3,5-tris(cinnamylideneamino) cyclohexane (L) have been prepared from a versatile precursor complex, Cu I (L)NCMeBF 4 , which incorporates a labile acetonitrile ligand that can be exchanged to give a range of ne... Read More about Syntheses of copper(I) cis-1,3,5-tri-iminocyclohexane complexes.

C-F Bond activation at Ni(0) and simple reactions of square planar Ni(II) fluoride complexes (2005)
Journal Article
Burling, S., Elliott, P. I., Jasim, N. A., Lindup, R. J., McKenna, J., Perutz, R. N., Archibald, S. J., & Whitwood, A. C. (2005). C-F Bond activation at Ni(0) and simple reactions of square planar Ni(II) fluoride complexes. Dalton Transactions : an international journal of inorganic chemistry, 3686-3695. https://doi.org/10.1039/b510052f

The reaction of Ni(COD) 2 (COD = 1,5-cyclooctadiene) with triethylphosphine and pentafluoropyridine in hexane has been shown previously to yield trans-[NiF(2-C 5 NF 4 )(PEt 3 ) 2 ] (1a) with a preference for reaction at the 2-position of the heteroa... Read More about C-F Bond activation at Ni(0) and simple reactions of square planar Ni(II) fluoride complexes.

Ammonothermal synthesis of a mesoporous Si-Ti-N composite material from a single-source precursor (2005)
Journal Article
Cheng, F., Kelly, S. M., Clark, S., Young, N. A., Archibald, S. J., Bradley, J. S., & Lefebvre, F. (2005). Ammonothermal synthesis of a mesoporous Si-Ti-N composite material from a single-source precursor. Chemistry of materials : a publication of the American Chemical Society, 17(22), 5594-5602. https://doi.org/10.1021/cm051401m

The preparation and structure of the novel compound bis(dimethylamino) silylamino-μ-bis[(dimethylamino)silylimino]titanium {Ti[NHSi(NMe 2 ) 3 ] 2 [μ-NSi(NMe 2 ) 3 ]} 2 , 1, are reported. Ammonolysis of compound 1 in an autoclave at 160°C gave a mes... Read More about Ammonothermal synthesis of a mesoporous Si-Ti-N composite material from a single-source precursor.

Mono-benzyl substituted cis,cis-1,3,5-triaminocyclohexanes (2005)
Journal Article
Archibald, S. J., Nairn, A. K., Timmins, P., & Walton, P. H. (2005). Mono-benzyl substituted cis,cis-1,3,5-triaminocyclohexanes. Tetrahedron letters; the international organ for the rapid publication of preliminary communications in organic chemistry, 46(38), 6441-6443. https://doi.org/10.1016/j.tetlet.2005.07.112

Unsymmetrical derivatives of the versatile molecule cis,cis-1,3,5- triaminocyclohexane (tach) have been prepared using a new metal-promoted synthesis to give the mono N-substituted tach ligands. This new method enables the synthesis of these molecule... Read More about Mono-benzyl substituted cis,cis-1,3,5-triaminocyclohexanes.