Outputs (73)

Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research (2019)
Journal Article
Soultanidis, G., Subiel, A., Renard, I., Reinhart, A. M., Green, V. L., Oelfke, U., Archibald, S. J., Greenman, J., Tulk, A., Walker, A., Schettino, G., & Cawthorne, C. J. (2019). Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research. Physics in Medicine and Biology, 64(12), Article 12NT02. https://doi.org/10.1088/1361-6560/ab215b

Significant improvements in radiotherapy are likely to come from biological rather than technical optimization, for example increasing tumour radiosensitivity via combination with targeted therapies. Such paradigms must first be evaluated in preclini... Read More about Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research.

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist (2019)
Journal Article
Burke, B. P., Miranda, C., Lee, R., Renard, I., Nigam, S., Clemente, G., D'Huys, T., Ruest, T., Domarkas, J., Thompson, J., Hubin, T., Schols, D., Cawthorne, C., & Archibald, S. J. (2020). 64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist. Journal of nuclear medicine, 61(1), 123-128. https://doi.org/10.2967/jnumed.118.218008

© 2020 by the Society of Nuclear Medicine and Molecular Imaging. Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, in autoimmune diseases, and during stem cell-based repair pro... Read More about 64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist.

Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads (2019)
Journal Article
Hubin, T. J., Walker, A. N., Davilla, D. J., Carder Freeman, T. R. N., Epley, B. M., Hasley, T. R., Amoyaw, P. N., Jain, S., Archibald, S. J., Prior, T. J., Krause, J. A., Oliver, A. G., Tekwani, B. L., & Khan, M. O. F. (2019). Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads. Polyhedron, 163, 42-53. https://doi.org/10.1016/j.poly.2019.02.027

© 2019 A total of 44 bis-aryl-monocyclic polyamines, monoaryl-monocyclic polyamines and their transition metal complexes were prepared, chemically characterized, and screened in vitro against the Leishmania donovani promastigotes, axenic amastigotes... Read More about Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads.

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles (2019)
Journal Article
Cain, A. N., Carder Freeman, T. N., Roewe, K. D., Cockriel, D. L., Hasley, T. R., Maples, R. D., Allbritton, E. M. A., D'Huys, T., van Loy, T., Burke, B. P., Prior, T. J., Schols, D., Archibald, S. J., & Hubin, T. J. (2019). Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles. Dalton Transactions : an international journal of inorganic chemistry, 48(8), 2785-2801. https://doi.org/10.1039/c8dt04728f

A number of disease states including WHIM syndrome, HIV infection and cancer have been linked to the chemokine receptor CXCR4. High-affinity CXCR4 antagonist transition metal complexes of configurationally restricted bis-tetraazamacrocyclic ligands h... Read More about Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.

Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm (2019)
Journal Article
Gandhi, R., Cawthorne, C., Craggs, L. J., Wright, J. D., Domarkas, J., He, P., Koch-Paszkowski, J., Shires, M., Scarsbrook, A. F., Archibald, S. J., Tsoumpas, C., & Bailey, M. A. (2019). Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm. Journal of Nuclear Cardiology, https://doi.org/10.1007/s12350-019-01946-y

© 2019, The Author(s). Background: Abdominal aortic aneurysm (AAA) is a focal aortic dilatation progressing towards rupture. Non-invasive AAA-associated cell proliferation biomarkers are not yet established. We investigated the feasibility of the cel... Read More about Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm.

Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion (2018)
Journal Article
Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., Hargreaves, R., Cawthorne, C., Archibald, S. J., & Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many... Read More about Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion.

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)
Journal Article
Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., Morice, A. H., Hart, S. P., & Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesi... Read More about Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis.

Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long-Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement (2018)
Journal Article
Mastrogiacomo, S., Kownacka, A. E., Dou, W., Burke, B. P., de Rosales, R. T., Heerschap, A., Jansen, J. A., Archibald, S. J., & Walboomers, X. F. (2018). Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long-Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement. Advanced Healthcare Materials, 7(19), Article 1800202. https://doi.org/10.1002/adhm.201800202

Direct in vivo monitoring of bioconstructs using noninvasive imaging modalities such as magnetic resonance imaging (MRI) or computed tomography (CT) is not possible for many materials. Calcium phosphate–based composites (CPCs) that are applicable to... Read More about Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long-Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement.

Increase of Direct C-C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes (2018)
Journal Article
Brewer, S. M., Wilson, K. R., Jones, D. G., Reinheimer, E. W., Archibald, S. J., Prior, T. J., Ayala, M. A., Foster, A. L., Hubin, T. J., & Green, K. N. (2018). Increase of Direct C-C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes. Inorganic chemistry, 57(15), 8890-8902. https://doi.org/10.1021/acs.inorgchem.8b00777

Macrocyclic ligands have been explored extensively as scaffolds for transition metal catalysts for oxygen and hydrogen atom transfer reactions. C–C reactions facilitated using earth abundant metals bound to macrocyclic ligands have not been well-unde... Read More about Increase of Direct C-C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes.

Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals (2018)
Journal Article
Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., Jenkins, D. G., & Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry: a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclid... Read More about Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals.

Synthesis, Crystal Structure, and Cytotoxicity Studies of titanacalix[4 and 8]arene Complexes (2018)
Journal Article
Miller-Shakesby, D. M., Nigam, S., Hughes, D. L., Lopez-Estelles, E., Elsegood, M. R., Cawthorne, C. J., Archibald, S. J., & Redshaw, C. (2018). Synthesis, Crystal Structure, and Cytotoxicity Studies of titanacalix[4 and 8]arene Complexes. Dalton Transactions : an international journal of inorganic chemistry, 47(27), 8992-8999. https://doi.org/10.1039/c8dt01992d

© 2018 The Royal Society of Chemistry. Reaction of 5,11,17,23-tetra-tert-butyl-dihydroxy-26,28-bis(2-pentoxy)calix[4]arene (L(OH)2(Opentyl)2) with [TiCl4] afforded the dichlorotitanoacalix[4]arene complex [TiCl2L(O)2(Opentyl)2] (1) in good yield. Hyd... Read More about Synthesis, Crystal Structure, and Cytotoxicity Studies of titanacalix[4 and 8]arene Complexes.

Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity (2018)
Journal Article
Jones, N. E., Burnett, C. A., Salamon, S., Landers, J., Wende, H., Lazzarini, L., Gibbs, P., Pickles, M., Johnson, B. R., Evans, D. J., Archibald, S. J., & Francesconi, M. G. (2018). Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity. Journal of Materials Chemistry B, 6(22), 3665-3673. https://doi.org/10.1039/c8tb00360b

Iron oxide nanoparticles (IONs) are being actively researched and experimented with as contrast agents for Magnetic Resonance Imaging (MRI), as well as image-directed delivery of therapeutics. The efficiency of an MRI contrast agent can be described... Read More about Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity.

A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6 (2018)
Journal Article
Keat, N., Kenny, J., Chen, K., Onega, M., Garman, N., Slack, R. J., Parker, C. A., Lumbers, R. T., Hallett, W., Saleem, A., Passchier, J., & Lukey, P. T. (2018). A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6. Journal of Nuclear Medicine Technology, 46(2), 136-143. https://doi.org/10.2967/jnmt.117.203547

The αvβ6 integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid αvβ6-binding peptide, derived from the foot and mouth virus (NAVPNLRGDLQVLAQKVART [A20FMDV2]), has been developed to image αvβ6 levels preclinicall... Read More about A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FBA20FMDV2 for Imaging the Integrin αvβ6.

Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus (2018)
Journal Article
Narayan, N., Owen, D. R., Mandhair, H., Smyth, E., Carlucci, F., Saleem, A., Gunn, R. N., Rabiner, E. A., Wells, L., Dakin, S. G., Sabokbar, A., & Taylor, P. C. (2018). Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus. Journal of nuclear medicine, 59(7), 1125-1132. https://doi.org/10.2967/jnumed.117.202200

PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely report... Read More about Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus.

Multimodal nanoparticle imaging agents: Design and applications (2017)
Journal Article
Burke, B. P., Cawthorne, C., & Archibald, S. J. (2017). Multimodal nanoparticle imaging agents: Design and applications. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 375(2107), 20170261. https://doi.org/10.1098/rsta.2017.0261

Molecular imaging, where the location of molecules or nanoscale constructs can be tracked in the body to report on disease or biochemical processes, is rapidly expanding to include combined modality or multimodal imaging. No single imaging technique... Read More about Multimodal nanoparticle imaging agents: Design and applications.

Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers (2016)
Journal Article
Voulgari, E., Bakandritsos, A., Galtsidis, S., Zoumpourlis, V., Burke, B. P., Clemente, G. S., Cawthorne, C., Archibald, S. J., Tuček, J., Zbořil, R., Kantarelou, V., Karydas, A. G., & Avgoustakis, K. (2016). Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers. Journal of controlled release : official journal of the Controlled Release Society, 243, 342-356. https://doi.org/10.1016/j.jconrel.2016.10.021

© 2016 Elsevier B.V. The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We investigated different poly(me... Read More about Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers.

Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes (2016)
Journal Article
Maples, R. D., Cain, A. N., Burke, B. P., Silversides, J. D., Mewis, R. E., D'huys, T., Schols, D., Linder, D. P., Archibald, S. J., & Hubin, T. J. (2016). Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes. Chemistry: a European journal, 22(36), 12916-12930. https://doi.org/10.1002/chem.201601468

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The CXCR4 chemokine receptor is implicated in a number of diseases including HIV infection and cancer development and metastasis. Previous studies have demonstrated that configurationally restricted... Read More about Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.

Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods (2016)
Journal Article
He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak aci... Read More about Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods.

Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors (2016)
Journal Article
Dubash, S. R., Nicholas Keat, Mapelli, P., Twyman, F., Carroll, L., Kozlowski, K., Al-Nahhas, A., Saleem, A., Huiban, M., Janisch, R., Frilling, A., Sharma, R., & Aboagye, E. O. (2016). Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors. Journal of nuclear medicine, 57(8), 1207-1213. https://doi.org/10.2967/jnumed.115.169532

© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc. We conducted the first-in-human study of 18F-fluoroethyl triazole [Tyr3] octreotate (18F-FET-βAG-TOCA) in patients with neuroendocrine tumors (NETs) to evaluate biodistribution, do... Read More about Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors.

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells (2016)
Journal Article
Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., Waby, J. S., Benoit, D. M., Seymour, A. M., Cawthorne, C., Higham, L. J., & Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart... Read More about Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.