Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis

Aliyu, Shamsuddeen A.; Avery, Ged; Cawthorne, Christopher; Archibald, Stephen J.; Kadir, Timor; Willaime, Julien M.Y.; Morice, Alyn H.; Hart, Simon P.; Crooks, Michael G.

Abstract

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesised that “microscopic” disease identified using PET would be heterogeneous because IPF is characterised histologically by patchy fibrosis. We applied textural analysis to PET scans to evaluate heterogeneity of [18F]-FDG uptake in lung regions that appeared normal on HRCT. We identified six textural features that demonstrated significantly more heterogeneous [18F]-FDG uptake in radiologically normal lung in IPF patients compared with controls. Textural analysis of lung PET-CT imaging is a novel approach to study early changes in IPF before HRCT abnormalities are apparent.

Citation

Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., Morice, A. H., Hart, S. P., & Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

• Journal Article Type: Letter
• Acceptance Date: Aug 24, 2018
• Online Publication Date: Sep 27, 2018
• Publication Date: Nov 1, 2018
• Deposit Date: Sep 30, 2018
• Publicly Available Date: Mar 28, 2020
• Journal: European Respiratory Journal
• Print ISSN: 0903-1936
• Electronic ISSN: 1399-3003
• Publisher: European Respiratory Society
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 5
• Article Number: 1801138
• Pages: 1801138
• DOI: https://doi.org/10.1183/13993003.01138-2018
• Keywords: Pulmonary and Respiratory Medicine
• Public URL: https://hull-repository.worktribe.com/output/1082135
• Publisher URL: http://erj.ersjournals.com/content/early/2018/08/30/13993003.01138-2018
• Contract Date: Oct 1, 2018