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Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis

Aliyu, Shamsuddeen A.; Avery, Ged; Cawthorne, Christopher; Archibald, Stephen J.; Kadir, Timor; Willaime, Julien M.Y.; Morice, Alyn H.; Hart, Simon P.; Crooks, Michael G.

Authors

Shamsuddeen A. Aliyu

Ged Avery

Christopher Cawthorne

Timor Kadir

Julien M.Y. Willaime

Alyn H. Morice

Simon P. Hart

Michael G. Crooks



Contributors

Alyn Morice
Researcher

M Crooks
Researcher

Abstract

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesised that “microscopic” disease identified using PET would be heterogeneous because IPF is characterised histologically by patchy fibrosis. We applied textural analysis to PET scans to evaluate heterogeneity of [18F]-FDG uptake in lung regions that appeared normal on HRCT. We identified six textural features that demonstrated significantly more heterogeneous [18F]-FDG uptake in radiologically normal lung in IPF patients compared with controls. Textural analysis of lung PET-CT imaging is a novel approach to study early changes in IPF before HRCT abnormalities are apparent.

Journal Article Type Letter
Publication Date Nov 1, 2018
Journal European respiratory journal
Print ISSN 0903-1936
Electronic ISSN 1399-3003
Publisher European Respiratory Society
Peer Reviewed Peer Reviewed
Volume 52
Issue 5
Article Number 1801138
Pages 1801138
APA6 Citation Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., …Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. The European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018
DOI https://doi.org/10.1183/13993003.01138-2018
Keywords Pulmonary and Respiratory Medicine
Publisher URL http://erj.ersjournals.com/content/early/2018/08/30/13993003.01138-2018

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