Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity

Jones, N. E.; Burnett, C. A.; Salamon, S.; Landers, J.; Wende, H.; Lazzarini, L.; Gibbs, P.; Pickles, M.; Johnson, B. R.G.; Evans, D. J.; Archibald, S. J.; Francesconi, M. G.

Abstract

Iron oxide nanoparticles (IONs) are being actively researched and experimented with as contrast agents for Magnetic Resonance Imaging (MRI), as well as image-directed delivery of therapeutics. The efficiency of an MRI contrast agent can be described by its longitudinal and transverse relaxivities, r 1 and r 2 . γ-Fe 2 O 3 nanoparticles-doped with fluoride in a controlled manner and functionalised with citric acid-showed a 3-fold increase in r 1 and a 17-fold increase in r 2 in a magnetic field of 3 T and almost 6-fold increase in r 1 and a 14-fold increase in r 2 at 11 T. Following fluorination, PXRD shows that the crystal structure of γ-Fe 2 O 3 is maintained, Mössbauer spectroscopy shows that the oxidation state of the Fe cation is unchanged and HREM shows that the particle size does not vary. However, magnetisation curves show a large increase in the coercive field, pointing towards a large increase in the magnetic anisotropy for the fluorinated nanoparticles compared to the un-doped γ-Fe 2 O 3 nanoparticles. Therefore, a chemically induced increase in magnetic anisotropy appears to be the most relevant parameter responsible for the large increase in relaxivity for γ-Fe 2 O 3 nanoparticles.

Citation

Jones, N. E., Burnett, C. A., Salamon, S., Landers, J., Wende, H., Lazzarini, L., Gibbs, P., Pickles, M., Johnson, B. R., Evans, D. J., Archibald, S. J., & Francesconi, M. G. (2018). Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity. Journal of Materials Chemistry B, 6(22), 3665-3673. https://doi.org/10.1039/c8tb00360b

• Journal Article Type: Article
• Acceptance Date: Mar 28, 2018
• Online Publication Date: Apr 4, 2018
• Publication Date: Apr 4, 2018
• Deposit Date: Apr 13, 2018
• Publicly Available Date: Apr 5, 2019
• Journal: Journal of Materials Chemistry B
• Print ISSN: 2050-750X
• Electronic ISSN: 2050-7518
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 22
• Pages: 3665-3673
• DOI: https://doi.org/10.1039/c8tb00360b
• Keywords: General Materials Science; General Chemistry; Biomedical Engineering; General Medicine
• Public URL: https://hull-repository.worktribe.com/output/778312
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2018/TB/C8TB00360B#!divAbstract
• Additional Information: : This document is Similarity Check deposited; : C. A. Burnett (ORCID); : C. A. Burnett (ResearcherID); : S. Salamon (ORCID); : J. Landers (ORCID); : H. Wende (ORCID); : B. R. G. Johnson (ORCID); : M. G. Francesconi (ORCID); : Single-blind; : Received 5 February 2018; Accepted 28 March 2018; Accepted Manuscript published 4 April 2018; Advance Article published 9 April 2018
• Contract Date: Apr 26, 2018