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Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity

Jones, N. E.; Burnett, C. A.; Salamon, S.; Landers, J.; Wende, H.; Lazzarini, L.; Gibbs, P.; Pickles, M.; Johnson, B. R.G.; Evans, D. J.; Archibald, S. J.; Francesconi, M. G.


N. E. Jones

C. A. Burnett

S. Salamon

J. Landers

H. Wende

L. Lazzarini

P. Gibbs

M. Pickles

B. R.G. Johnson

D. J. Evans


Iron oxide nanoparticles (IONs) are being actively researched and experimented with as contrast agents for Magnetic Resonance Imaging (MRI), as well as image-directed delivery of therapeutics. The efficiency of an MRI contrast agent can be described by its longitudinal and transverse relaxivities, r 1 and r 2 . γ-Fe 2 O 3 nanoparticles-doped with fluoride in a controlled manner and functionalised with citric acid-showed a 3-fold increase in r 1 and a 17-fold increase in r 2 in a magnetic field of 3 T and almost 6-fold increase in r 1 and a 14-fold increase in r 2 at 11 T. Following fluorination, PXRD shows that the crystal structure of γ-Fe 2 O 3 is maintained, Mössbauer spectroscopy shows that the oxidation state of the Fe cation is unchanged and HREM shows that the particle size does not vary. However, magnetisation curves show a large increase in the coercive field, pointing towards a large increase in the magnetic anisotropy for the fluorinated nanoparticles compared to the un-doped γ-Fe 2 O 3 nanoparticles. Therefore, a chemically induced increase in magnetic anisotropy appears to be the most relevant parameter responsible for the large increase in relaxivity for γ-Fe 2 O 3 nanoparticles.


Jones, N. E., Burnett, C. A., Salamon, S., Landers, J., Wende, H., Lazzarini, L., Gibbs, P., Pickles, M., Johnson, B. R., Evans, D. J., Archibald, S. J., & Francesconi, M. G. (2018). Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity. Journal of Materials Chemistry B, 6(22), 3665-3673.

Journal Article Type Article
Acceptance Date Mar 28, 2018
Online Publication Date Apr 4, 2018
Publication Date Apr 4, 2018
Deposit Date Apr 13, 2018
Publicly Available Date Apr 5, 2019
Journal Journal of Materials Chemistry B
Print ISSN 2050-750X
Electronic ISSN 2050-7518
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
Issue 22
Pages 3665-3673
Keywords General Materials Science; General Chemistry; Biomedical Engineering; General Medicine
Public URL
Publisher URL!divAbstract
Additional Information : This document is Similarity Check deposited; : C. A. Burnett (ORCID); : C. A. Burnett (ResearcherID); : S. Salamon (ORCID); : J. Landers (ORCID); : H. Wende (ORCID); : B. R. G. Johnson (ORCID); : M. G. Francesconi (ORCID); : Single-blind; : Received 5 February 2018; Accepted 28 March 2018; Accepted Manuscript published 4 April 2018; Advance Article published 9 April 2018
Contract Date Apr 26, 2018


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