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Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion

Burke, Benjamin P.; Grantham, William; Burke, Michael J.; Nichol, Gary S.; Roberts, David; Renard, Isaline; Hargreaves, Rebecca; Cawthorne, Christopher; Archibald, Stephen J.; Lusby, Paul J.

Authors

Benjamin P. Burke

William Grantham

Michael J. Burke

Gary S. Nichol

David Roberts

Isaline Renard

Rebecca Hargreaves

Christopher Cawthorne

Paul J. Lusby



Abstract

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the I-emitting [99mTc]TcO4- anion, under conditions compatible with in vivo administration. Subsequent single-photon emission computed tomography imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.

Journal Article Type Article
Publication Date Dec 12, 2018
Journal Journal of the American Chemical Society
Print ISSN 0002-7863
Electronic ISSN 1520-5126
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 140
Issue 49
Pages 16877-16881
APA6 Citation Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., …Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582
DOI https://doi.org/10.1021/jacs.8b09582
Publisher URL https://pubs.acs.org/doi/10.1021/jacs.8b09582

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.



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