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Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion

Burke, Benjamin P.; Grantham, William; Burke, Michael J.; Nichol, Gary S.; Roberts, David; Renard, Isaline; Hargreaves, Rebecca; Cawthorne, Christopher; Archibald, Stephen J.; Lusby, Paul J.

Authors

Benjamin P. Burke

William Grantham

Michael J. Burke

Gary S. Nichol

David Roberts

Isaline Renard

Rebecca Hargreaves

Christopher Cawthorne

Paul J. Lusby



Abstract

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the I-emitting [99mTc]TcO4- anion, under conditions compatible with in vivo administration. Subsequent single-photon emission computed tomography imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.

Citation

Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., …Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

Journal Article Type Article
Acceptance Date Nov 28, 2018
Online Publication Date Nov 28, 2018
Publication Date Dec 12, 2018
Deposit Date Jun 22, 2019
Publicly Available Date Nov 29, 2019
Journal Journal of the American Chemical Society
Print ISSN 0002-7863
Electronic ISSN 1520-5126
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 140
Issue 49
Pages 16877-16881
DOI https://doi.org/10.1021/jacs.8b09582
Public URL https://hull-repository.worktribe.com/output/1195239
Publisher URL https://pubs.acs.org/doi/10.1021/jacs.8b09582
Related Public URLs https://www.research.ed.ac.uk/portal/en/publications/visualizing-kinetically-robust-co4l6liii-assemblies-in-vivo-spect-imaging-of-the-encapsulated-tc99mtco4-anion(6a940edf-60f7-4055-b9b2-a3e4df0ec5c5).html

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.






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