Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion

Burke, Benjamin P.; Grantham, William; Burke, Michael J.; Nichol, Gary S.; Roberts, David; Renard, Isaline; Hargreaves, Rebecca; Cawthorne, Christopher; Archibald, Stephen J.; Lusby, Paul J.

Abstract

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the I-emitting [99mTc]TcO4- anion, under conditions compatible with in vivo administration. Subsequent single-photon emission computed tomography imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.

Citation

Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., Hargreaves, R., Cawthorne, C., Archibald, S. J., & Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

• Journal Article Type: Article
• Acceptance Date: Nov 28, 2018
• Online Publication Date: Nov 28, 2018
• Publication Date: Dec 12, 2018
• Deposit Date: Jun 22, 2019
• Publicly Available Date: Nov 29, 2019
• Journal: Journal of the American Chemical Society
• Print ISSN: 0002-7863
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 140
• Issue: 49
• Pages: 16877-16881
• DOI: https://doi.org/10.1021/jacs.8b09582
• Public URL: https://hull-repository.worktribe.com/output/1195239
• Publisher URL: https://pubs.acs.org/doi/10.1021/jacs.8b09582
• Related Public URLs: https://www.research.ed.ac.uk/portal/en/publications/visualizing-kinetically-robust-co4l6liii-assemblies-in-vivo-spect-imaging-of-the-encapsulated-tc99mtco4-anion(6a940edf-60f7-4055-b9b2-a3e4df0ec5c5).html
• Contract Date: Jun 24, 2019