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Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals

Tarn, Mark D.; Kızılyer, Nuray Yavuzkanat; Esfahani, Mohammad M. N.; Joshi, Pankaj; Brown, Nathaniel J.; Pamme, Nicole; Jenkins, David G.; Archibald, Stephen J.

Authors

Mark D. Tarn

Nuray Yavuzkanat Kızılyer

Mohammad M. N. Esfahani

Pankaj Joshi

David G. Jenkins



Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide [18F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

Journal Article Type Article
Publication Date Sep 18, 2018
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 24
Issue 52
Pages 13749-13753
APA6 Citation Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., …Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry : a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395
DOI https://doi.org/10.1002/chem.201802395
Keywords Liquid chromatography; Microfluidics; Plastic scintillator; Positron emission tomography
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201802395
Copyright Statement ©2018 University of Hull

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