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Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals

Tarn, Mark D.; K?z?lyer, Nuray Yavuzkanat; Esfahani, Mohammad M. N.; Joshi, Pankaj; Brown, Nathaniel J.; Pamme, Nicole; Jenkins, David G.; Archibald, Stephen J.

Authors

Mark D. Tarn

Nuray Yavuzkanat K?z?lyer

Mohammad M. N. Esfahani

Pankaj Joshi

Nathaniel J. Brown

Nicole Pamme

David G. Jenkins



Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide [18F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

Citation

Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., Jenkins, D. G., & Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry: a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395

Journal Article Type Article
Acceptance Date Jul 9, 2018
Online Publication Date Jul 13, 2018
Publication Date Sep 18, 2018
Deposit Date Jul 12, 2018
Publicly Available Date Jul 14, 2019
Print ISSN 0947-6539
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 24
Issue 52
Pages 13749-13753
DOI https://doi.org/10.1002/chem.201802395
Keywords Liquid chromatography; Microfluidics; Plastic scintillator; Positron emission tomography
Public URL https://hull-repository.worktribe.com/output/923614
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201802395
Contract Date Jul 12, 2018

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