Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals

Tarn, Mark D.; K?z?lyer, Nuray Yavuzkanat; Esfahani, Mohammad M. N.; Joshi, Pankaj; Brown, Nathaniel J.; Pamme, Nicole; Jenkins, David G.; Archibald, Stephen J.

Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide [18F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

Citation

Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., …Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry: a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395

• Journal Article Type: Article
• Acceptance Date: Jul 9, 2018
• Online Publication Date: Jul 13, 2018
• Publication Date: Sep 18, 2018
• Deposit Date: Jul 12, 2018
• Publicly Available Date: Jul 14, 2019
• Print ISSN: 0947-6539
• Electronic ISSN: 1521-3765
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 52
• Pages: 13749-13753
• DOI: https://doi.org/10.1002/chem.201802395
• Keywords: Liquid chromatography; Microfluidics; Plastic scintillator; Positron emission tomography
• Public URL: https://hull-repository.worktribe.com/output/923614
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201802395