Welcome to Repository@Hull

Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trial (2025)
Journal Article
Chen, Q., Zhang, M., Zhang, L., Aierken, A., Dong, R., Xu, X., Yu, L., Lai, K., & Qiu, Z. (2025). Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trial. EClinicalMedicine, 86, Article 103367. https://doi.org/10.1016/j.eclinm.2025.103367

Background
The antitussive potential of flupentixol-melitracen, an anti-anxiety and anti-depression compound, has been observed previously. We aimed to further evaluate its efficacy and safety in patients with refractory chronic cough (RCC) who were... Read More about Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trial.

Functional goals and outcomes of rehabilitation within palliative care: a multicentre prospective cohort study (2025)
Journal Article
Maddocks, M., Fettes, L., Takemura, N., Bayly, J., Talbot-Rice, H., Turner, K., Tiberini, R., Harding, R., E.M. Murtagh, F., Siegert, R. J., Higginson, I. J., Ashford, S. A., & Turner-Stokes, L. (2025). Functional goals and outcomes of rehabilitation within palliative care: a multicentre prospective cohort study. BMC Palliative Care, 24(1), Article 172. https://doi.org/10.1186/s12904-025-01816-0

Background: Rehabilitation is an integral component of palliative care. An understanding of functional goals can help tailor interventions and support the evaluation of services. This study examined the nature and timescale of functional goals in pal... Read More about Functional goals and outcomes of rehabilitation within palliative care: a multicentre prospective cohort study.

A watershed fragility index for assessing the vulnerability of river ecosystems (2025)
Journal Article
Lira, K. C., Jong, M. V. Z. D., King, M., & Cowx, I. G. (2025). A watershed fragility index for assessing the vulnerability of river ecosystems. Ecological Indicators, 178, Article 113908. https://doi.org/10.1016/j.ecolind.2025.113908

Accelerating impacts of climate change have heightened the vulnerability of ecosystems, posing critical challenges to biodiversity conservation. While current climate change vulnerability assessment frameworks provide valuable insights, they often fa... Read More about A watershed fragility index for assessing the vulnerability of river ecosystems.

Parents' experiences of paediatric end-of-life care in the UK: A multisite qualitative study (2025)
Journal Article
Peat, G., McLorie, E. V., Barrett, L., Weatherly, H., Hinde, S., Lake Walker, G., Noyes, J., Oddie, S., Vasudevan, C., Feltbower, R., Phillips, B., Hewitt, C. E., Hain, R., Subramanian, G., Haynes, A., Fraser, L., Murtagh, F., & Hackett, J. (in press). Parents' experiences of paediatric end-of-life care in the UK: A multisite qualitative study. BMJ Supportive & Palliative Care, https://doi.org/10.1136/spcare-2025-005427

Objectives: Despite the marked improvement in child mortality over the last two decades, more than 7 million infants, children and young people still die worldwide every year. In the UK, four National Health Service settings care for more than 60% of... Read More about Parents' experiences of paediatric end-of-life care in the UK: A multisite qualitative study.

Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions (2025)
Journal Article
Darlay, R., Shah, R. L., Dodds, R. M., Nair, A. T., Pearson, E. R., Witham, M. D., Cordell, H. J., & ADMISSION Research Collaborative. (2025). Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions. Genetic Epidemiology, 49(5), Article e70012. https://doi.org/10.1002/gepi.70012

Genetic correlation analysis can provide useful insight into the shared genetic basis between traits or conditions of interest. However, most genome-wide analyses only inform about the degree of global (overall) genetic similarity and do not identify... Read More about Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions.