Outputs (6)

Assessment of mitochondrial dysfunction and implications in cardiovascular disorders (2022)
Journal Article
Li, Y., Ma, Y., Dang, Q. Y., Fan, X. R., Han, C. T., Xu, S. Z., & Li, P. Y. (2022). Assessment of mitochondrial dysfunction and implications in cardiovascular disorders. Life Sciences, 306, Article 120834. https://doi.org/10.1016/j.lfs.2022.120834

Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production, intracellular Ca2+ cycling, and apoptosis. During the past decade, exte... Read More about Assessment of mitochondrial dysfunction and implications in cardiovascular disorders.

Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells (2021)
Journal Article
Zaibi, N., Li, P., & Xu, S.-Z. (in press). Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells. PLoS ONE, 16(2), Article e0247234. https://doi.org/10.1371/journal.pone.0247234

Elevated reactive oxygen species (ROS) in type 2 diabetes cause cellular damage in many organs. Recently, the new class of glucose-lowering agents, SGLT-2 inhibitors, have been shown to reduce the risk of developing diabetic complications; however, t... Read More about Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells.

Evaluating trastuzumab in the treatment of HER2 positive breast cancer (2020)
Journal Article
Jaques, R., Xu, S., & Matsakas, A. (2020). Evaluating trastuzumab in the treatment of HER2 positive breast cancer. Histology and Histopathology, 35(10), 1059-1075. https://doi.org/10.14670/HH-18-221

© 2020, Histology and Histopathology. All rights reserved. The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin®), a humanise... Read More about Evaluating trastuzumab in the treatment of HER2 positive breast cancer.

Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis (2020)
Journal Article
Su, D.-N., Wu, S.-P., & Xu, S.-Z. (2020). Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis. Stem Cell Research and Therapy, 11(1), Article 395. https://doi.org/10.1186/s13287-020-01911-4

Background
Bone mesenchymal stem cells (MSCs) can promote liver regeneration and inhibit inflammation and hepatic fibrosis. MSCs also can serve as a vehicle for gene therapy. Smad7 is an essential negative regulatory gene in the TGF-β1/Smad signalli... Read More about Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis.

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility (2019)
Journal Article
Farmer, L., Rollason, R., Whitcomb, D., Ni, L., Goodlif, A., Lay, A., Birnbaumer, L., Heesom, K., Xu, S.-Z., Saleem, M., & Welsh, G. (2019). TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Journal of the American Society of Nephrology : JASN, 30(10), 1910-1924. https://doi.org/10.1681/ASN.2018070729

BACKGROUND:
Mutations in the transient receptor potential channel 6 (TRPC6) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with TRPC6 mutations do not present with any other pathologic phenotype, suggesti... Read More about TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility.

TRPC channel activation by extracellular thioredoxin (2008)
Journal Article
Xu, S.-Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C. J., Bahnasi, Y. M., Al-Shawaf, E., Porter, K. E., Jiang, L.-H., Emery, P., Sivaprasadarao, A., & Beech, D. J. (2008). TRPC channel activation by extracellular thioredoxin. Nature, 451(7174), 69-72. https://doi.org/10.1038/nature06414

Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identificati... Read More about TRPC channel activation by extracellular thioredoxin.