Chemistry

Electrochemical quantification of D-glucose during the production of bioethanol from thermo-mechanically pre-treated wheat straw (2021)
Journal Article
Ward, R. A., Charlton, A., Welham, K. J., Baker, P., Zein, S. H., Tomkinson, J., Richards, D. I., Kelly, S. M., Lawrence, N. S., & Wadhawan, J. D. (2021). Electrochemical quantification of D-glucose during the production of bioethanol from thermo-mechanically pre-treated wheat straw. Electrochemistry communications, 124, Article 106942. https://doi.org/10.1016/j.elecom.2021.106942

Mechanical pre-treatment (disc refining) of wheat straw, at both atmospheric and elevated pressure, is shown to be an efficient process to access fermentable monosaccharides, with the potential to integrate within the infrastructure of existing first... Read More about Electrochemical quantification of D-glucose during the production of bioethanol from thermo-mechanically pre-treated wheat straw.

An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method (2019)
Journal Article
Hibbert, S., Welham, K., & Zein, S. H. (2019). An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method. SN Applied Sciences, 1(11), Article 1467. https://doi.org/10.1007/s42452-019-1457-5

The production of energy and chemicals from waste biomass is an attractive alternative by comparison with first generation biofuels and fossil feedstocks. This paper investigates oil extraction from spent coffee grounds (SCG) by means of an advanced... Read More about An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method.

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., Loubani, M., Rivero, F., Matsakas, A., Benoit, D. M., Wade, M., Greenman, J., & Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Background
The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More about The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism (2016)
Journal Article
Vasiliadou, R., Esfahani, M. M. N., Brown, N. J., & Welham, K. J. (2016). A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism. Sensors, 16(9), Article ARTN 1418. https://doi.org/10.3390/s16091418

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler... Read More about A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism.

Optimization preparation of the biosynthesis of silver nanoparticles using watermelon and study of its antibacterial activity (2014)
Journal Article
Alzahrani, E., & Welham, K. (in press). Optimization preparation of the biosynthesis of silver nanoparticles using watermelon and study of its antibacterial activity. International Journal of Basic and Applied Sciences, 3(4), 392. https://doi.org/10.14419/ijbas.v3i4.3358

The field of nanotechnology is the most active area of research in modern materials science. There is increased demand on nanoparticles because of their wide applicability in various areas; for example, electronics, catalysis, chemistry, energy and m... Read More about Optimization preparation of the biosynthesis of silver nanoparticles using watermelon and study of its antibacterial activity.

Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins (2013)
Journal Article
Alzahrani, E., & Welham, K. (2014). Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins. Analytical Methods, 6(2), 558-568. https://doi.org/10.1039/c3ay41442f

Protein identification by mass spectrometry forms the cornerstone of proteomics. Commonly, the identification of proteins is based on digestion of proteins into peptides using proteolytic enzymes. Cleavage of the disulphide bonds in proteins before e... Read More about Fabrication of a TCEP-immobilised monolithic silica microchip for reduction of disulphide bonds in proteins.

Preconcentration of milk proteins using octadecylated monolithic silica microchip (2013)
Journal Article
Alzahrani, E., & Welham, K. (2013). Preconcentration of milk proteins using octadecylated monolithic silica microchip. Analytica Chimica Acta, 798, 40-47. https://doi.org/10.1016/j.aca.2013.08.035

Sample preparation is a bottleneck in systems for chemical analysis and it is a required step in order to remove interference and preconcentrate the target analytes. Much research in recent years has focused on porous monolithic materials since they... Read More about Preconcentration of milk proteins using octadecylated monolithic silica microchip.

Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen (2013)
Journal Article
Kashuba, E., Eagle, G. L., Bailey, J., Evans, P., Welham, K. J., Allsup, D., & Cawkwell, L. (2013). Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen. Journal of Proteomics, 91, 478-485. https://doi.org/10.1016/j.jprot.2013.08.002

CLL is an incurable disease with variable prognosis. The hyper reactivity of the B-cell receptor (BCR) to unknown antigen ligation plays a pivotal role in CLL-cell survival. We aimed to investigate the BCR signalling pathway using proteomics to ident... Read More about Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen.

Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’” (2011)
Journal Article
Zheng, S., Webster, A., Zheng, S., Welham, K. J., Dyer, C. E., Greenman, J., Haswell, S. J., Webster, A., Zheng, S., Welham, K. J., Dyer, C. E., Greenman, J., Haswell, S. J., Zheng, S., Webster, A., Welham, K. J., Dyer, C. E., Greenman, J., Haswell, S. J., Zheng, S., …Haswell, S. J. (2011). Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’”. Analyst, 136(2), 411-411. https://doi.org/10.1039/c0an00729c

Comment by Tsikas et al. (Analyst, 2011, DOI: 10.1039/c0an00411a) on the preliminary work by Shen and colleagues (Analyst, 2010, 135, 302) describing the use of ESI-MS/MS for the detection of methylpiperazinobenzenediamine, as a probe for NO in tissu... Read More about Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’”.

Identification of a female sex pheromone in Carcinus maenas (2011)
Journal Article
Hardege, J. D., Bartels-Hardege, H. D., Fletcher, N., Terschak, J. A., Harley, M., Smith, M. A., Davidson, L., Hayden, D., Müller, C. T., Lorch, M., Welham, K., Walther, T., & Bublitz, R. (2011). Identification of a female sex pheromone in Carcinus maenas. Marine ecology progress series, 436, 177-189. https://doi.org/10.3354/meps09226

Despite major progress in our understanding of animal signaling systems, the identification of chemical signals in aquatic organisms is still in its infancy. Exemplary for this is the lack of structural knowledge of crustacean sex pheromones despite... Read More about Identification of a female sex pheromone in Carcinus maenas.

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