Outputs (5)

Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei (2019)
Journal Article
Zheng, F., Colasante, C., & Voncken, F. (2019). Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei. Molecular and Biochemical Parasitology, 233, Article 111221. https://doi.org/10.1016/j.molbiopara.2019.111221

Similar to higher eukaryotes, the protist parasite T. brucei harbours several iron-containing proteins that regulate DNA and protein processing, oxidative stress defence and mitochondrial respiration. The synthesis of these proteins occurs either in... Read More about Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei.

Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei (2018)
Thesis
Alshegifi, M. Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221223

Trypanosoma brucei is a medically important protozoan parasite that causes African sleeping sickness in humans. Although disease treatment is possible, it is hindered by the limited availability of effective drugs and the rapid emergence of drug resi... Read More about Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei.

A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei (2018)
Journal Article
Colasante, C., Zheng, F., Kemp, C., & Voncken, F. (2018). A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei. Molecular and Biochemical Parasitology, 221, 36-51. https://doi.org/10.1016/j.molbiopara.2018.03.003

The procyclic form of the human parasite Trypanosoma brucei harbors one single, large mitochondrion containing all tricarboxylic acid (TCA) cycle enzymes and respiratory chain complexes present also in higher eukaryotes. Metabolite exchange among sub... Read More about A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei.

Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei (2017)
Thesis
Zheng, F. Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221817

Trypanosoma brucei is a medically important protozoan parasite causing African sleeping sickness in humans. Treatment of this disease is possible, but is hindered by the limited availability of effective drugs as well as the rapid emergence of drug r... Read More about Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei.

The phosphoarginine energy-buffering system of Trypanosoma brucei is essential and involves multiple arginine kinase isoforms with different subcellular locations. (2013)
Journal Article
Voncken, F., Gao, F., Wadforth, C., Harley, M., & Colasante, C. (2013). The phosphoarginine energy-buffering system of Trypanosoma brucei is essential and involves multiple arginine kinase isoforms with different subcellular locations. PLoS ONE, 8(6), e65908. https://doi.org/10.1371/journal.pone.0065908

Phosphagen energy-buffering systems play an essential role in regulating the cellular energy homeostasis in periods of high-energy demand or energy supply fluctuations. Here we describe the phosphoarginine/arginine kinase system of the kinetoplastid... Read More about The phosphoarginine energy-buffering system of Trypanosoma brucei is essential and involves multiple arginine kinase isoforms with different subcellular locations..