Outputs (704)

Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence (2015)
Journal Article
Lucock, M., Yates, Z., Martin, C., Choi, J.-H., Beckett, E., Boyd, L., LeGras, K., Ng, X., Skinner, V., Wai, R., Kho, J., Roach, P., & Veysey, M. (2015). Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence. Bba Clinical, 3, 107-112. https://doi.org/10.1016/j.bbacli.2014.11.005

Purpose
The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homoc... Read More about Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.

Meridians Under the Skin (2014)
Journal Article
Shaw, V., & Aland, R. C. (2014). Meridians Under the Skin. European Journal of Oriental Medicine, 7(6),

The physical nature of the acupuncture meridian system is currently the subject of enquiry. The original structural descriptions for the meridian system contained in the Huang Di Nei Jing, The Yellow Emperor's Canon of Internal Medicine, are detailed... Read More about Meridians Under the Skin.

c-MYC is a radiosensitive locus in human breast cells (2014)
Journal Article
Wade, M. A., Sunter, N. J., Fordham, S. E., Long, A., Masic, D., Russell, L. J., Harrison, C. J., Rand, V., Elstob, C., Bown, N., Rowe, D., Lowe, C., Cuthbert, G., Bennett, S., Crosier, S., Bacon, C. M., Onel, K., Scott, K., Scott, D., Travis, L. B., …Allan, J. M. (2015). c-MYC is a radiosensitive locus in human breast cells. Oncogene, 34(38), 4985-4994. https://doi.org/10.1038/onc.2014.427

Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising radiation compared with older women, and that risk is... Read More about c-MYC is a radiosensitive locus in human breast cells.

High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling (2014)
Journal Article
Daskoulidou, N., Xu, S. Z., Zeng, B., Gomez, M. F., Berglund, L. M., Atkin, S. L., Jiang, H., Griffin, S., Ayoola, J., Bhandari, S., Kotova, O., Chen, G. L., Griffin, S., Jiang, H., Berglund, L. M., Zeng, B., & Daskoulidou, N. (2015). High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling. Journal of Molecular Medicine, 93(5), 511-521. https://doi.org/10.1007/s00109-014-1234-2

© 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx.... Read More about High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling.

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. https://doi.org/10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More about Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.

Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor (2014)
Journal Article
Crooks, M. G., Fahim, A., Naseem, K. M., Morice, A. H., & Hart, S. P. (2014). Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor. PLoS ONE, 9(10), Article ARTN e111347. https://doi.org/10.1371/journal.pone.0111347

Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood. Activated platelets can release pro-fibrotic mediators th... Read More about Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor.

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis (2014)
Journal Article
Kotecha, D., Holmes, J., Krum, H., Altman, D. G., Manzano, L., Cleland, J. G., Lip, G. Y., Coats, A. J., Andersson, B., Kirchhof, P., Von Lueder, T. G., Wedel, H., Rosano, G., Shibata, M. C., Rigby, A., & Flather, M. D. (2014). Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis. Lancet, 384(9961), 2235-2243. https://doi.org/10.1016/S0140-6736%2814%2961373-8

Background: Atrial fibrillation and heart failure often coexist, causing substantial cardiovascular morbidity and mortality. β blockers are indicated in patients with symptomatic heart failure with reduced ejection fraction; however, the efficacy of... Read More about Efficacy of β blockers in patients with heart failure plus atrial fibrillation: An individual-patient data meta-analysis.

A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency (2014)
Journal Article
Carradice, D., Wallace, T., Gohil, R., & Chetter, I. (2014). A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency. Annals of Surgery, 260(2), 396-401. https://doi.org/10.1097/sla.0000000000000541

Objective: To test the hypothesis that patients with soft tissue changes related to superficial venous insufficiency (SVI) have greater benefits from treatment than those with only symptomatic varicose veins.
Background: A commonly held view is that... Read More about A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency.

A comparison of physical activity preferences among breast, prostate, and colorectal cancer survivors in Nova Scotia, Canada (2014)
Journal Article
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2015). A comparison of physical activity preferences among breast, prostate, and colorectal cancer survivors in Nova Scotia, Canada. Journal of Physical Activity and Health, 12(6), 823-833. https://doi.org/10.1123/jpah.2014-0119

Background:
Physical activity (PA) preferences may vary by cancer survivor group, but few studies have made direct comparisons. The purpose of this study was to compare the PA preferences of breast, prostate, and colorectal cancer survivors in Nova S... Read More about A comparison of physical activity preferences among breast, prostate, and colorectal cancer survivors in Nova Scotia, Canada.

Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients (2014)
Journal Article
Drennan, S., Stafford, N. D., Greenman, J., & Green, V. L. (2014). Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients. Journal of clinical & cellular immunology, 5(4), Article 241. https://doi.org/10.4172/2155-9899.1000241

Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response. However, their immunosu... Read More about Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients.