Outputs (7)

Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite (2025)
Journal Article
Rezaee, S., Wright, C. E., Morice, A. H., & Rostami-Hodjegan, A. (2025). Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite. The Journal of Clinical Pharmacology, https://doi.org/10.1002/jcph.70049

To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double-blind, randomized, placebo-controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge tes... Read More about Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite.

Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment (2025)
Journal Article
Birring, S. S., Dicpinigaitis, P. V., Maher, T. M., Mazzone, S. B., Page, C. P., Hawi, A., Sciascia, T., & Morice, A. H. (2025). Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment. Lung, 203, Article 62. https://doi.org/10.1007/s00408-025-00812-8

Chronic cough is a significant burden on patient quality of life and is associated with poor health outcomes. Chronic cough may be a result of neural hypersensitivity due to changes in both the peripheral and the central nervous systems, although the... Read More about Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment.

Classification for long-term monitoring of cough. Case Study (2025)
Journal Article
den Brinker, A. C., Rietman, R., Ouweltjes, O., van Marion, M., Thackray-Nocera, S., Crooks, M. G., & Morice, A. H. (2025). Classification for long-term monitoring of cough. Case Study. Discover Artificial Intelligence, 5, Article 56. https://doi.org/10.1007/s44163-025-00264-2

For management of chronic respiratory diseases, unobtrusive longitudinal monitoring of cough has been proposed. Such a monitoring system was developed using a classifier trained on an initial observation period. After this initial period, a personali... Read More about Classification for long-term monitoring of cough. Case Study.

Unmet needs and future directions of treatment options for chronic cough (2025)
Journal Article
Zhang, M., & Morice, A. (2025). Unmet needs and future directions of treatment options for chronic cough. Expert Review of Respiratory Medicine, https://doi.org/10.1080/17476348.2025.2499663

Introduction: Chronic cough is a persistent condition that significantly affects patients’ quality of life and poses diagnostic and therapeutic challenges. Traditional anatomical diagnostic approaches often fail to address the underlying mechanisms,... Read More about Unmet needs and future directions of treatment options for chronic cough.

Cough frequency has a high daily variation in patients with chronic cough (2025)
Journal Article
Morice, A., Alge, M., Kuett, L., Hart, S., Rigby, A., & Elkayam, D. (2025). Cough frequency has a high daily variation in patients with chronic cough. ERJ Open Research, 11(1), Article 00670-2024. https://doi.org/10.1183/23120541.00670-2024

Opening paragraph:
Chronic cough (coughing lasting 8 weeks or longer) is a burdensome disease, causing low quality of life due to the disruption that frequent coughing causes to daily life. Its prevalence is estimated to be 10% of the global populat... Read More about Cough frequency has a high daily variation in patients with chronic cough.

Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients (2025)
Journal Article
den Brinker, A. C., Ouweltjes, O., Rietman, R., Thackray-Nocera, S., Crooks, M. G., & Morice, A. H. (2025). Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients. Sensors, 25(2), Article 404. https://doi.org/10.3390/s25020404

Coughing is a symptom of many respiratory diseases. An increased amount of coughs may signal an (upcoming) health issue, while a decreasing amount of coughs may indicate an improved health status. The presence of a cough can be identified by a cough... Read More about Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients.

Can Passive Cough Monitoring Predict COPD Exacerbations? (2025)
Journal Article
Morice, A. H., den Brinker, A. C., Crooks, M., Thackray-Nocera, S., Ouweltjes, O., & Rietman, R. (2025). Can Passive Cough Monitoring Predict COPD Exacerbations?. COPD: Journal of Chronic Obstructive Pulmonary Disease, 22(1), Article 2487909. https://doi.org/10.1080/15412555.2025.2487909

Purpose: Validation of an alert mechanism for COPD exacerbations based on coughing detected by a stationary unobtrusive nighttime monitor. Methods: This prospective double-blind longitudinal study of cough monitoring included 40 chronic obstructive p... Read More about Can Passive Cough Monitoring Predict COPD Exacerbations?.