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Outputs (28)

Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate (2011)
Journal Article
Morice, A. H., McGarvey, L. P., & Dicpinigaitis, P. V. (2012). Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate. Lung, 190(1), 3-9. https://doi.org/10.1007/s00408-011-9351-y

The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and gastroesophageal reflux di... Read More about Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate.

Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials (2011)
Journal Article
Shahin, Y., Khan, J. A., & Chetter, I. (2012). Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis, 221(1), 18-33. https://doi.org/10.1016/j.atherosclerosis.2011.12.005

ObjectiveSeveral studies have assessed the effect of angiotensin converting enzyme inhibitors (ACEIs) on arterial stiffness and wave reflections as measured by pulse wave velocity (PWV) and augmentation index (AIx), respectively. We conducted a meta-... Read More about Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Bronchoconstriction and airway remodeling [2] (2011)
Journal Article
Morjaria, J., Hart, S., & Morice, A. H. (2011). Bronchoconstriction and airway remodeling [2]. New England Journal of Medicine, 365(12), 1156-1157. https://doi.org/10.1056/NEJMc1107353

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study (2011)
Journal Article
Hatfield, J., Carradice, D., Mazari, F. A. K., Josie, H., Samuel, N., Chetter, I., & Wallace, T. (2012). Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study. Phlebology, 27(3), 128-134. https://doi.org/10.1258/phleb.2011.011014

ObjectiveMany venous trials mix patients with great saphenous vein (GSV) and small saphenous vein (SSV) diseases. There is no evidence that both respond similarly to treatment and our aim was to test this assumption.Method This cohort study compares... Read More about Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study.

Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey (2011)
Journal Article
Khan, J. A., Mazari, F. A., Abdul Rahman, M., Mockford, K., Chetter, I. C., & McCollum, P. T. (2011). Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey. Annals of vascular surgery, 25(7), 878-886. https://doi.org/10.1016/j.avsg.2011.05.013

BackgroundTo evaluate patients' awareness, functional outcome, and satisfaction after abdominal aortic aneurysm (AAA) repair.MethodsA study-specific questionnaire was developed with collaboration of a multidisciplinary team. Lists of patients who und... Read More about Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey.

Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough (2011)
Journal Article
Pacheco, A., Faro, V., Cobeta, I., Royuela, A., Molyneux, I., & Morice, A. H. (2011). Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough. Respirology : official journal of the Asian Pacific Society of Respirology, 16(6), 994-999. https://doi.org/10.1111/j.1440-1843.2011.02010.x

Background and objective: Patients with eosinophilic airway inflammation (EAI) often show a therapeutic response to corticosteroids. Non-invasive methods of diagnosing EAI are potentially useful in guiding therapy, particularly in conditions such as... Read More about Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough.