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Outputs (99)

Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis (2022)
Journal Article
Allen, R. J., Stockwell, A., Oldham, J. M., Guillen-Guio, B., Schwartz, D. A., Maher, T. M., Flores, C., Noth, I., Yaspan, B. L., Jenkins, R. G., & Wain, L. V. (2022). Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis. Thorax, 77, 829-833. https://doi.org/10.1136/thoraxjnl-2021-218577

Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition with poor survival times. We previously published a genome-wide meta-analysis of IPF risk across three studies with independent replication of associated variants in two additional studi... Read More about Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.

Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study (2022)
Journal Article
Friedrich, C., Francke, K., Gashaw, I., Scheerans, C., Klein, S., Fels, L., Smith, J. A., Hummel, T., & Morice, A. (2022). Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study. Clinical Pharmacokinetics, 61, 1143–1156. https://doi.org/10.1007/s40262-022-01126-1

Background and Objective: There is no licensed treatment for refractory chronic cough; off-label therapies have limited efficacy and can produce adverse effects. Excessive adenosine triphosphate signaling via P2X3 receptors is implicated in refractor... Read More about Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study.

Compression following treatment of superficial venous incompetence: systematic review (2022)
Journal Article
Mohamed, A. H., Thadani, S., Mohamed, S. H., Sidapra, M., Smith, G., Chetter, I., & Carradice, D. (2022). Compression following treatment of superficial venous incompetence: systematic review. British journal of surgery, 109(8), 679-685. https://doi.org/10.1093/bjs/znac116

BACKGROUND: International guidelines recommend postprocedural compression when treating symptomatic superficial venous incompetence (SVI). This updated review of RCTs investigated the requirement for postprocedural compression and how it can be appli... Read More about Compression following treatment of superficial venous incompetence: systematic review.

Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients (2022)
Journal Article
Ettelaie, C., Benelhaj, N., Featherby, S., Haque, F., Johnson, M., Cooke, J., & Maraveyas, A. (2022). Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients. Journal of Biotechnology and Biomedicine, 5(2), 78-93. https://doi.org/10.26502/jbb.2642-280050

Predicting which cancer patients are at risk of thrombosis remains a key challenge to effective thromboprophylaxis. This study was based on the hypothesis that the rapid release of TF-containing MV occurs in cancer cells that possess high levels of T... Read More about Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients.

Research priorities for vascular wounds: results of the Vascular Society GBI/James Lind Alliance Priority Setting Process (2022)
Journal Article
Long, J., Lathan, R., Sidapra, M., Gronlund, T., Chetter, I., & on behalf of the Vascular Society of Great Britain and Ireland Wounds Special Interest Group. (2022). Research priorities for vascular wounds: results of the Vascular Society GBI/James Lind Alliance Priority Setting Process. Journal of Vascular Societies Great Britain and Ireland, 1(4), 110-116. https://doi.org/10.54522/jvsgbi.2022.027

Background: The management of vascular wounds is often a complex and prolonged process that impacts individuals’ quality of life, is challenging for clinicians and results in a significant financial burden to the NHS. UK wound care practices vary con... Read More about Research priorities for vascular wounds: results of the Vascular Society GBI/James Lind Alliance Priority Setting Process.

Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough (2022)
Journal Article
Dicpinigaitis, P. V., Birring, S. S., Blaiss, M., McGarvey, L. P., Morice, A. H., Pavord, I. D., Satia, I., Smith, J. A., La Rosa, C., Li, Q., Nguyen, A. M., Schelfhout, J., Tzontcheva, A., & Muccino, D. (2023). Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough. Annals of Allergy, Asthma and Immunology, 130(1), 60-66. https://doi.org/10.1016/j.anai.2022.05.003

Background: The current characterization of patients with refractory or unexplained chronic cough (RCC and UCC, respectively) primarily stems from relatively small clinical studies. Objective: To report the baseline medical history and clinical chara... Read More about Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough.

Abnormal Uterine Bleeding in Perimenopausal Women: The Role of Hysteroscopy and Its Impact on Quality of Life and Sexuality (2022)
Journal Article
Vitale, S. G., Watrowski, R., Barra, F., D’alterio, M. N., Carugno, J., Sathyapalan, T., Kahramanoglu, I., Reyes-Muñoz, E., Lin, L. T., Urman, B., Ferrero, S., & Angioni, S. (2022). Abnormal Uterine Bleeding in Perimenopausal Women: The Role of Hysteroscopy and Its Impact on Quality of Life and Sexuality. Diagnostics, 12(5), Article 1176. https://doi.org/10.3390/diagnostics12051176

Abnormal uterine bleeding (AUB) is a frequent symptom in perimenopausal women. It is defined as uterine bleeding in which the duration, frequency, or amount of bleeding is considered excessive and negatively affects the woman’s quality of life (QoL)... Read More about Abnormal Uterine Bleeding in Perimenopausal Women: The Role of Hysteroscopy and Its Impact on Quality of Life and Sexuality.

The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer (2022)
Thesis
Bullock, A. F. The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4484119

Background: Older adults with cancer are a complex and growing population requiring tailored care to achieve optimum treatment outcomes. However, their care is complicated by underrecognised
and under-treated nutrition-related wasting disorders: mal... Read More about The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer.

Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review (2022)
Journal Article
Babaie, F., Omraninava, M., Gorabi, A. M., Khosrojerdi, A., Aslani, S., Yazdchi, A., Torkamandi, S., Mikaeili, H., Sathyapalan, T., & Sahebkar, A. (2022). Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review. Current Genomics, 23(3), 163-174. https://doi.org/10.2174/1389202923666220527111037

Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of... Read More about Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review.