Outputs (68)

Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response (2020)
Journal Article
Fadul, M. M., Heath, P. R., Cooper-Knock, J., Kurz, J. M., Al-Azzawi, H. A., Ali, Z., Smith, T., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21(21), Article 7924. https://doi.org/10.3390/ijms21217924

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL, n = 7) and radiologically-normal-appearing (control) periventricular white matter... Read More about Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response.

Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study (2020)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., Olsen, K., Lloyd, J., Petrides, G., McKeith, I. G., & Thomas, A. J. (2021). Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study. American Journal of Geriatric Psychiatry, 29(3), 272-284. https://doi.org/10.1016/j.jagp.2020.07.018

Objective: We explored whether the mild cognitive impairment (MCI) stages of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) differ in their cognitive profiles, and longitudinal progression. Design: A prospective, longitudinal design was u... Read More about Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study.

Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort (2020)
Journal Article
Chambers, A., Bury, J. J., Minett, T., Richardson, C. D., Brayne, C., Ince, P. G., Shaw, P. J., Garwood, C. J., Heath, P. R., Simpson, J. E., Matthews, F. E., & Wharton, S. B. (2020). Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79(9), 950-958. https://doi.org/10.1093/JNEN/NLAA064

Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the Cognitive Function and A... Read More about Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort.

Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia (2020)
Journal Article
Zheng, L., Matthews, F. E., & Anstey, K. J. (2021). Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia. Age and ageing, 50(1), 169-175. https://doi.org/10.1093/ageing/afaa111

Background: Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dem... Read More about Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia.

Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II (2020)
Journal Article
Grossi, C. M., Richardson, K., Savva, G. M., Fox, C., Arthur, A., Loke, Y. K., Steel, N., Brayne, C., Matthews, F. E., Robinson, L., Myint, P. K., & Maidment, I. D. (2020). Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II. BMC Geriatrics, 20(1), Article 267. https://doi.org/10.1186/s12877-020-01657-x

Background: Anticholinergic medication use is linked with increased cognitive decline, dementia, falls and mortality, and their use should be limited in older people. Here we estimate the prevalence of anticholinergic use in England's older populatio... Read More about Increasing prevalence of anticholinergic medication use in older people in England over 20 years: Cognitive function and ageing study i and II.

Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., Zammit, A., Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Archives of Gerontology and Geriatrics, 91, Article 104112. https://doi.org/10.1016/j.archger.2020.104112

Background: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods: Parti... Read More about Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment.

Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium (2020)
Journal Article
Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., Bis, J. C., Blacker, D., Bos, D., Brayne, C., Dartigues, J. F., Darweesh, S. K., Davis-Plourde, K. L., De Wolf, F., Debette, S., Dufouil, C., Fornage, M., Goudsmit, J., Grasset, L., Gudnason, V., …Hofman, A. (2020). Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology, 95(5), E519-E531. https://doi.org/10.1212/WNL.0000000000010022

Objective To determine changes in the incidence of dementia between 1988 and 2015.MethodsThis analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Al... Read More about Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.

Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis (2020)
Journal Article
Pieper, N. T., Grossi, C. M., Chan, W. Y., Loke, Y. K., Savva, G. M., Haroulis, C., Steel, N., Fox, C., Maidment, I. D., Arthur, A. J., Myint, P. K., Smith, T. O., Robinson, L., Matthews, F. E., Brayne, C., & Richardson, K. (2020). Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis. Age and ageing, 49(6), 939-947. https://doi.org/10.1093/ageing/afaa090

Background: the long-term effect of the use of drugs with anticholinergic activity on cognitive function remains unclear. Methods: we conducted a systematic review and meta-analysis of the relationship between anticholinergic drugs and risk of dement... Read More about Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: A meta-analysis.

The COVID-19 pandemic and health inequalities (2020)
Journal Article
Bambra, C., Riordan, R., Ford, J., & Matthews, F. (2020). The COVID-19 pandemic and health inequalities. Journal of Epidemiology and Community Health, 74(11), 964-968. https://doi.org/10.1136/jech-2020-214401

This essay examines the implications of the COVID-19 pandemic for health inequalities. It outlines historical and contemporary evidence of inequalities in pandemics - drawing on international research into the Spanish influenza pandemic of 1918, the... Read More about The COVID-19 pandemic and health inequalities.

APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline (2020)
Journal Article
Makkar, S. R., Lipnicki, D. M., Crawford, J. D., Kochan, N. A., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Brayne, C., Stephan, B., Matthews, F., Llibre-Rodriguez, J. J., Llibre-Guerra, J. J., Valhuerdi-Cepero, A. J., Lipton, R. B., Katz, M. J., CuilingWang, Ritchie, K., Carles, S., Carriere, I., Scarmeas, N., …Sachdev, P. (2020). APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline. The journals of gerontology. Series A, Biological sciences and medical sciences, 75(10), 1863-1873. https://doi.org/10.1093/gerona/glaa116

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals ag... Read More about APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline.