Outputs (64)

Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials (2023)
Journal Article
Sidebottom, D. B., Huang, C., Carradice, D., Holt, P. J., John-Pierre, K., & Roy, I. N. (2023). Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials. BMJ open, 13(8), Article e072355. https://doi.org/10.1136/bmjopen-2023-072355

INTRODUCTION: The optimal antithrombotic regimen to reduce the risk of vascular events in patients with peripheral arterial disease (PAD) is contentious. This systematic review and network meta-analysis (NMA) aims to define the relative efficacy and... Read More about Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials.

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients (2023)
Journal Article
Haque, F., Ryde, J., Broughton, L., Huang, C., Sethi, S., Stephens, A., Pillai, A., Mirza, S., Brown, V., Avery, G., Bozas, G., & Maraveyas, A. (2023). Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients. ERJ Open Research, 9(3), Article 00651-2022. https://doi.org/10.1183/23120541.00651-2022

Background Clinical prediction rules (CPRs) developed to predict adverse outcomes of suspected pulmonary embolism (PE) and facilitate outpatient management have limitations in discriminating outcomes for ambulatory cancer patients with unsuspected PE... Read More about Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients.

Telemedicine in addictions: Feasibility randomised controlled trial (2023)
Journal Article
Mayet, S., Gledhill, A., McCaw, I., Hashmani, Z., Drozdova, Z., Arshad, S., Shahbaz, S., Huang, C., & Phillips, T. (2023). Telemedicine in addictions: Feasibility randomised controlled trial. Heroin Addiction and Related Clinical Problems, 25(3), 27-36

Background. Opioid dependence is high risk. Opioid agonist treatment (OAT) improves outcomes and reduces deaths. Nonattendance at addiction specialist prescribers who monitor OAT worsens outcomes. Telemedicine has been shown to improve attendance wit... Read More about Telemedicine in addictions: Feasibility randomised controlled trial.

Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis (2022)
Journal Article
Walshaw, J., Lathan, R., Huang, C., Staniland, T., Chetter, I., & Pymer, S. (2023). Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis. Journal of Vascular Societies Great Britain and Ireland, 2(2), 91-96. https://doi.org/10.54522/jvsgbi.2022.053

Background: The ankle brachial pressure index (ABPI) is a common diagnostic tool used in the assessment of peripheral arterial disease (PAD). The Doppler ultrasound technique is regarded as the gold-standard method for ABPI measurement; however, time... Read More about Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis.

Paediatric early warning systems: Not a simple answer to a complex question (2022)
Journal Article
Roland, D., Powell, C., Lloyd, A., Trubey, R., Tume, L., Sefton, G., Huang, C., Taiyari, K., Strange, H., Jacob, N., Thomas-Jones, E., Hood, K., & Allen, D. (2023). Paediatric early warning systems: Not a simple answer to a complex question. Archives of Disease in Childhood, 108(5), 338-343. https://doi.org/10.1136/archdischild-2022-323951

Paediatric early warning systems (PEWS) to reduce in-hospital mortality have been a laudable endeavour. Evaluation of their impact has rarely examined the internal validity of the components of PEWS in achieving desired outcomes. We highlight the ass... Read More about Paediatric early warning systems: Not a simple answer to a complex question.

Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial (2022)
Journal Article
Souroullas, P., Barnes, R., Carradice, D., Smith, G., Huang, C., & Chetter, I. (2022). Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial. British journal of surgery, 109(5), 426-432. https://doi.org/10.1093/bjs/znac053

BACKGROUND: Lower limb amputation (LLA) is typically described as 'clean surgery', but surgical-site infection (SSI) rates are high and there is significant variation in antibiotic prophylaxis practice. This study aimed to determine whether an extend... Read More about Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial.

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol (2022)
Journal Article
Northgraves, M., Allsup, D., Cohen, J., Huang, C., Turgoose, J., & Ali, S. (2022). A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol. PLoS ONE, 17(2), Article e0263195. https://doi.org/10.1371/journal.pone.0263195

Background
Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking... Read More about A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial (2022)
Journal Article
Waldron, C. A., Thomas-Jones, E., Bernatoniene, J., Brookes-Howell, L., Faust, S. N., Faust, S. N., Harris, D., Hinds, L., Hood, K., Huang, C., Mateus, C., Pallmann, P., Patel, S., Paulus, S., Peak, M., Powell, C., Preston, J., & Carrol, E. D. (2022). Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial. BMJ open, 12(1), Article e047490. https://doi.org/10.1136/bmjopen-2020-047490

Introduction Procalcitonin (PCT) is a biomarker more specific for bacterial infection and responds quicker than other commonly used biomarkers such as C reactive protein, but is not routinely used in the National Health Service (NHS). Studies mainly... Read More about Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial.

Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study (2022)
Journal Article
Allen, D., Lloyd, A., Edwards, D., Grant, A., Hood, K., Huang, C., Hughes, J., Jacob, N., Lacy, D., Moriarty, Y., Oliver, A., Preston, J., Sefton, G., Skone, R., Strange, H., Taiyari, K., Thomas-Jones, E., Trubey, R., Tume, L., Powell, C., & Roland, D. (2022). Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study. Health and Social Care Delivery Research, 10(1), 307. https://doi.org/10.3310/CHCK4556

Objectives: (1) Identify, through systematic review, the following: evidence for core components of effective paediatric track-and-trigger tools and paediatric early warning systems, and contextual factors consequential for paediatric track-and-trigg... Read More about Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study.