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Outputs (91)

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

Introduction Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-met... Read More about Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.

BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India (2025)
Journal Article
Clark, J., Salins, N., Sherigar, M., Williams, S., Pearson, M., Rao, S. R., Spathis, A., Bhat, R., Currow, D. C., Fraser, K., Simha, S., & Johnson, M. J. (2025). BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India. NPJ Primary Care Respiratory Medicine, 35(1), Article 13. https://doi.org/10.1038/s41533-025-00420-2

Breathlessness is highly prevalent in low and middle-income countries (LMICs). Low-cost, non-drug, breathlessness self-management interventions are effective in high-income countries. However, health beliefs influence acceptability and have not been... Read More about BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India.

Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase (2025)
Journal Article
Ekström, M., Alameri, F., Chang, S., Ferreira, D., Johnson, M. J., & Currow, D. C. (in press). Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2025.02.020

Context: Morphine to treat severe chronic breathlessness might increase adverse events (AEs). Objectives: We aimed to evaluate the risk of AEs in relation to dose, duration and titration phase of regular, low-dose sustained-release (SR) oral morphine... Read More about Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase.

ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions (2025)
Journal Article
Luckett, T., Swan, F., Clark, J., Roberts, M., Pearson, M., Hutchinson, A., Currow, D., Kochovska, S., Crooks, M., Smith, T., & Johnson, M. (2025). ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions. European respiratory journal, 65(2), Article 2402244. https://doi.org/10.1183/13993003.02244-2024

"I'm living in a 'no' world now…"- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symptom in an older, frail community-based population (2025)
Journal Article
Elliott-Button, H., Johnson, M. J., Hutchinson, A., Currow, D. C., & Clark, J. (2025). "I'm living in a 'no' world now…"- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symptom in an older, frail community-based population. NPJ Primary Care Respiratory Medicine, 35(1), Article 5. https://doi.org/10.1038/s41533-024-00409-3

Chronic breathlessness is a debilitating symptom with detrimental impact on individuals and carers. However, little is known about the experiences of community-dwelling, frail, older adults living with chronic breathlessness. To explore, (i) the psyc... Read More about "I'm living in a 'no' world now…"- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symptom in an older, frail community-based population.

Breathlessness without borders: a call to action for global breathlessness research (2024)
Journal Article
Clark, J. D., Binnie, K., Bond, M., Crooks, M., Currow, D. C., Curry, J., Elsey, H., Habib, M., Hutchinson, A., Soyiri, I., Johnson, M. J., Nair, S., Rao, S., Siqueira-Filha, N., Spathis, A., & Williams, S. (2024). Breathlessness without borders: a call to action for global breathlessness research. NPJ Primary Care Respiratory Medicine, 34(1), Article 26. https://doi.org/10.1038/s41533-024-00384-9

It is likely that the burden of breathlessness in low and middle-income countries (LMICs) is much higher than has been estimated using calculations of disease burden and expected prevalence of the symptom. However, most breathlessness research has be... Read More about Breathlessness without borders: a call to action for global breathlessness research.

Mirtazapine to alleviate severe breathlessness in patients with COPD or ILD: an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial (BETTER-B) (2024)
Journal Article
Higginson, I. J., Brown, S. T., Oluyase, A. O., May, P., Maddocks, M., Costantini, M., Bajwah, S., Normand, C., Bausewein, C., Simon, S. T., Ryan, K., Currow, D. C., Johnson, M., Hart, S. P., Mather, H., Krajnik, M., Tanzi, S., Ghirotto, L., Bolton, C., Janowiak, P., …Brown, J. M. (2024). Mirtazapine to alleviate severe breathlessness in patients with COPD or ILD: an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial (BETTER-B). Lancet, 12(10), 763-774. https://doi.org/10.1016/S2213-2600%2824%2900187-5

Background
Breathlessness frequently becomes severe among people with respiratory disease. Mirtazapine, a widely used antidepressant, showed promise. We determined the effectiveness of mirtazapine to alleviate severe persisting breathlessness.
Meth... Read More about Mirtazapine to alleviate severe breathlessness in patients with COPD or ILD: an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial (BETTER-B).

The cost of providing care by family and friends (informal care) in the last year of life: A population observational study (2024)
Journal Article
Johnson, M. J., Currow, D. C., Chynoweth, J., Weatherly, H., Keser, G., Hutchinson, A., Jones, A., Dunn, L., & Allgar, V. (2024). The cost of providing care by family and friends (informal care) in the last year of life: A population observational study. Palliative medicine, https://doi.org/10.1177/02692163241259649

Introduction: Little is known about replacement costs of care provided by informal carers during the last year of life for people dying of cancer and non-cancer diseases. Aim: To estimate informal caregiving costs and explore the relationship with ca... Read More about The cost of providing care by family and friends (informal care) in the last year of life: A population observational study.

Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research (2024)
Journal Article
Kochovska, S., Murtagh, F. E., Agar, M., Phillips, J. L., Dudgeon, D., Lujic, S., Johnson, M., & Currow, D. C. (2024). Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research. Palliative medicine, https://doi.org/10.1177/02692163241234227

Background: Palliative care is characterised by heterogeneous patient and caregiver populations who are provided care in different health systems and a research base including a large proportion of observational, mostly retrospective studies. The inh... Read More about Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research.