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Outputs (54)

Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: A prospective, community-based study (2021)
Journal Article
Dennis, A., Wamil, M., Alberts, J., Oben, J., Cuthbertson, D. J., Wootton, D., Crooks, M., Gabbay, M., Brady, M., Hishmeh, L., Attree, E., Heightman, M., Banerjee, R., & Banerjee, A. (2021). Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: A prospective, community-based study. BMJ open, 11(3), Article e048391. https://doi.org/10.1136/bmjopen-2020-048391

Objective To assess medium-term organ impairment in symptomatic individuals following recovery from acute SARS-CoV-2 infection. Design Baseline findings from a prospective, observational cohort study. Setting Community-based individuals from two UK c... Read More about Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: A prospective, community-based study.

Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It? (2021)
Journal Article
Sykes, D. L., Holdsworth, L., Jawad, N., Gunasekera, P., Morice, A. H., & Crooks, M. G. (2021). Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?. Lung, 199(2), 113-119. https://doi.org/10.1007/s00408-021-00423-z

© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature. The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the l... Read More about Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?.

The impact of the first covid-19 surge on severe asthma patients in the uk. Which is worse: The virus or the lockdown? (2021)
Journal Article
Smith, S. J., Busby, J., Heaney, L. G., Pfeffer, P. E., Jackson, D. J., Yang, F., Fowler, S. J., Menzies-Gow, A., Idris, E., Brown, T., Gore, R., Faruqi, S., Dennison, P., Dodd, J. W., Doe, S., Mansur, A. H., Priyadarshi, R., Holmes, J., Hearn, A., Al-Aqqad, H., …Chaudhuri, R. (2021). The impact of the first covid-19 surge on severe asthma patients in the uk. Which is worse: The virus or the lockdown?. ERJ Open Research, 7(1), Article 00768-2020. https://doi.org/10.1183/23120541.00768-2020

Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis (2020)
Journal Article
Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020

Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 an... Read More about Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis.

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial (2020)
Journal Article
Monk, P. D., Marsden, R. J., Tear, V. J., Brookes, J., Batten, T. N., Mankowski, M., Gabbay, F. J., Davies, D. E., Holgate, S. T., Ho, L. P., Clark, T., Djukanovic, R., Wilkinson, T. M. A., Crooks, M. G., Dosanjh, D. P., Siddiqui, S., Rahman, N. M., Smith, J. A., Horsley, A., Harrison, T. W., …Rodrigues, P. M. (2021). Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial. The lancet. Respiratory medicine, 9(2), 196-206. https://doi.org/10.1016/S2213-2600%2820%2930511-7

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries a substantial risk of severe and prolonged illness; treatment options are currently limited. We assessed the efficacy and safety of inhaled nebulised interfero... Read More about Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial.

Evidence generation for the clinical impact of mycopd in patients with mild, moderate and newly diagnosed copd: A randomised controlled trial (2020)
Journal Article
Crooks, M. G., Elkes, J., Storrar, W., Roy, K., North, M., Blythin, A., Watson, A., Cornelius, V., & Wilkinson, T. M. (2020). Evidence generation for the clinical impact of mycopd in patients with mild, moderate and newly diagnosed copd: A randomised controlled trial. ERJ Open Research, 6(4), Article 00460-2020. https://doi.org/10.1183/23120541.00460-2020

Self-management interventions in COPD aim to improve patients’ knowledge, skills and confidence to make correct decisions, thus improving health status and outcomes. myCOPD is a web-based self-management app known to improve inhaler use and exercise... Read More about Evidence generation for the clinical impact of mycopd in patients with mild, moderate and newly diagnosed copd: A randomised controlled trial.

Azithromycin for sarcoidosis cough: an open label exploratory clinical trial (2020)
Journal Article
Fraser, S. D., Thackray-Nocera, S., Shepherd, M., Flockton, R., Wright, C., Sheedy, W., Brindle, K., Morice, A. H., Kaye, P. M., Crooks, M. G., & Hart, S. P. (2020). Azithromycin for sarcoidosis cough: an open label exploratory clinical trial. ERJ Open Research, 6(4), Article 00534. https://doi.org/10.1183/23120541.00534-2020

Background: Chronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis... Read More about Azithromycin for sarcoidosis cough: an open label exploratory clinical trial.

COVID-19 progression, frailty, and use of prolonged continuous positive airway pressure as a ward-based treatment: Lessons to be learnt from a case (2020)
Journal Article
Sykes, D., Parthasarthy, A., Brown, O., Crooks, M., & Faruqi, S. (2021). COVID-19 progression, frailty, and use of prolonged continuous positive airway pressure as a ward-based treatment: Lessons to be learnt from a case. Lung India, 38(Suppl.1), S64-S68. https://doi.org/10.4103/lungindia.lungindia_583_20

© 2021 Wolters Kluwer Medknow Publications. All rights reserved. Coronavirus disease 19 (COVID-19) poses the greatest public health threat in 100 years, with cases rising rapidly in many countries around the world. We report a case of a 78-year-old f... Read More about COVID-19 progression, frailty, and use of prolonged continuous positive airway pressure as a ward-based treatment: Lessons to be learnt from a case.