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Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey

Shoaib, A.; Farag, M.; Nolan, J.; Rigby, A.; Patwala, A.; Rashid, M.; Kwok, C. S.; Perveen, R.; Clark, A.; Komajda, M.; Cleland, J. G.F.

Authors

A. Shoaib

M. Farag

J. Nolan

A. Rigby

A. Patwala

M. Rashid

C. S. Kwok

R. Perveen

A. Clark

M. Komajda

J. G.F. Cleland



Abstract

© 2018, The Author(s). Background: Heart failure is heterogeneous in aetiology, pathophysiology, and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one reason for repeated failures. Methods: The first EuroHeart Failure Survey screened consecutive deaths and discharges of patients with suspected heart failure during 2000–2001. Patients were sorted into seven mutually exclusive hierarchical presentations: (1) with cardiac arrest/ventricular arrhythmia; (2) with acute coronary syndrome; (3) with rapid atrial fibrillation; (4) with acute breathlessness; (5) with other symptoms/signs such as peripheral oedema; (6) with stable symptoms; and (7) others in whom the contribution of HF to admission was not clear. Results: The 10,701 patients enrolled were classified into the above seven presentations as follows: 260 (2%), 560 (5%), 799 (8%), 2479 (24%), 1040 (10%), 703 (7%), and 4691 (45%) for which index-admission mortality was 26%, 20%, 10%, 8%, 6%, 6%, and 4%, respectively. Compared to those in group 7, the hazard ratios for death during the index admission were 4.9 (p ≤ 0.001), 4.0 (p < 0.001), 2.2 (p < 0.001), 2.1 (p < 0.001), 1.4 (p < 0.04) and 1.4 (p = 0.04), respectively. These differences were no longer statistically significant by 12 weeks. Conclusion: There is great diversity in the presentation of heart failure that is associated with very different short-term outcomes. Only a minority of hospitalizations associated with suspected heart failure are associated with acute breathlessness. This should be taken into account in the design of future clinical trials.

Journal Article Type Article
Publication Date 2019-05
Print ISSN 1861-0684
Electronic ISSN 1861-0692
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 108
Issue 5
Pages 510-519
APA6 Citation Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., …Cleland, J. G. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey. Clinical Research in Cardiology, 108(5), 510-519. https://doi.org/10.1007/s00392-018-1380-6
DOI https://doi.org/10.1007/s00392-018-1380-6
Keywords Acute heart failure; Presentation of heart failure; Mortality
Publisher URL https://link.springer.com/article/10.1007%2Fs00392-018-1380-6

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Copyright Statement
© The Author(s) 2018
Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.





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