Skip to main content

Research Repository

Advanced Search

Ionic Imbalances and Coupling in Synchronization of Responses in Neurons

Sadegh-Zadeh, Seyed-Ali; Kambhampati, Chandrasekhar; Davis, Darryl N


Seyed-Ali Sadegh-Zadeh

Darryl N Davis


Most neurodegenerative diseases (NDD) are a result of changes in the chemical composition of neurons. For example, Alzheimer's disease (AD) is the product of Aβ peptide deposition which results in changes in the ion concentration. These changes in ion concentration affect the responses of the neuron to stimuli and often result in inducing excessive excitation or inhibition. This paper investigates the dynamics of a single neuron as ion changes occur. These changes are incorporated using the Nernst equation. Within the central and peripheral nervous system, signals and hence rhythms, are propagated through the coupling of the neurons. It was found that under certain conditions the coupling strength between two neurons could mitigate changes in ion concentration. By defining the state of perfect synchrony, it was shown that the effect of ion imbalance in coupled neurons was reduced while in uncoupled neurons these changes had a more significant impact on the neuronal behavior.


Sadegh-Zadeh, S., Kambhampati, C., & Davis, D. N. (2019). Ionic Imbalances and Coupling in Synchronization of Responses in Neurons. J — Multidisciplinary Scientific Journal, 2(1), 17-40.

Journal Article Type Article
Acceptance Date Jan 4, 2019
Online Publication Date Jan 10, 2019
Publication Date Jan 10, 2019
Deposit Date Jan 13, 2019
Publicly Available Date Jan 15, 2019
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 2
Issue 1
Pages 17-40
Keywords Neurodegenerative diseases; Action potential dynamics; Electrophysiology; Coupled neurons; Gap junctions; Synchronization; The region of synchronicity; Ion imbalances; Coupling conductance; Nerve impulse
Public URL
Publisher URL


You might also like

Downloadable Citations