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Ionic Imbalances and Coupling in Synchronization of Responses in Neurons

Sadegh-Zadeh, Seyed-Ali; Kambhampati, Chandrasekhar; Davis, Darryl N

Authors

Seyed-Ali Sadegh-Zadeh

Darryl N Davis d.n.davis@hull.ac.uk (D.N.D.) * Correspondence: ss1095@bristol.ac.uk



Abstract

Most neurodegenerative diseases (NDD) are a result of changes in the chemical composition of neurons. For example, Alzheimer's disease (AD) is the product of Aβ peptide deposition which results in changes in the ion concentration. These changes in ion concentration affect the responses of the neuron to stimuli and often result in inducing excessive excitation or inhibition. This paper investigates the dynamics of a single neuron as ion changes occur. These changes are incorporated using the Nernst equation. Within the central and peripheral nervous system, signals and hence rhythms, are propagated through the coupling of the neurons. It was found that under certain conditions the coupling strength between two neurons could mitigate changes in ion concentration. By defining the state of perfect synchrony, it was shown that the effect of ion imbalance in coupled neurons was reduced while in uncoupled neurons these changes had a more significant impact on the neuronal behavior.

Citation

Sadegh-Zadeh, S., Kambhampati, C., & Davis, D. N. (2019). Ionic Imbalances and Coupling in Synchronization of Responses in Neurons. J, 2(1), 17-40. doi:10.3390/j2010003

Journal Article Type Article
Acceptance Date Jan 4, 2019
Online Publication Date Jan 10, 2019
Publication Date Jan 10, 2019
Deposit Date Jan 13, 2019
Publicly Available Date Jan 15, 2019
Journal J — Multidisciplinary Scientific Journal
Print ISSN 2571-8800
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 2
Issue 1
Pages 17-40
DOI https://doi.org/10.3390/j2010003
Keywords Neurodegenerative diseases; Action potential dynamics; Electrophysiology; Coupled neurons; Gap junctions; Synchronization; The region of synchronicity; Ion imbalances; Coupling conductance; Nerve impulse
Public URL https://hull-repository.worktribe.com/output/1211579
Publisher URL https://www.mdpi.com/2571-8800/2/1/3/htm

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).



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