Association between omega-3 index and blood lipids in older Australians

Ferguson, Jessica J.A.; Veysey, Martin; Lucock, Mark; Niblett, Suzanne; King, Katrina; MacDonald-Wicks, Lesley; Garg, Manohar L.

Abstract

Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturated fatty acid (PUFA) has been shown to modulate blood lipid profiles and reduce the risk of developing CVD. However, studies relating objective measures of long-term dietary n-3 PUFA intake and circulating lipid levels in older adults are limited. Thus, we aimed to determine whether there is an association between erythrocyte n-3 PUFA status (omega-3 index, O3I) and blood lipid profiles in older adults. A sample of adults aged 65–95 years who participated in the Retirement Health and Lifestyle Study was evaluated. Outcome measures included O3I (% eicosapentaenoic acid+% docosahexaenoic acid) and fasting blood lipid profiles [total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride (TG)]. Two hundred and seventy-six subjects were included in the analyses. The mean±SD age was 77.6±7.4 years, and 40.9% were males. O3I was significantly higher in females compared to males. O3I was inversely associated with plasma TG (P

Citation

Ferguson, J. J., Veysey, M., Lucock, M., Niblett, S., King, K., MacDonald-Wicks, L., & Garg, M. L. (2016). Association between omega-3 index and blood lipids in older Australians. Journal of Nutritional Biochemistry, 27, 233-240. https://doi.org/10.1016/j.jnutbio.2015.09.010

• Journal Article Type: Article
• Acceptance Date: Sep 8, 2015
• Online Publication Date: Sep 25, 2015
• Publication Date: 2016-01
• Deposit Date: Apr 25, 2019
• Journal: The Journal of Nutritional Biochemistry
• Print ISSN: 0955-2863
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Pages: 233-240
• DOI: https://doi.org/10.1016/j.jnutbio.2015.09.010
• Keywords: n-3 PUFA; Omega 3 index; Hyperlipidemia; Lipids; Older adults; Cholesterol
• Public URL: https://hull-repository.worktribe.com/output/1647374
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0955286315002466?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: Association between omega-3 index and blood lipids in older Australians; Journal Title: The Journal of Nutritional Biochemistry; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jnutbio.2015.09.010; Content Type: article; Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.