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A longitudinal cohort study of symptoms and other concerns among Nigerian people with stages 3–5 chronic kidney diseases: study protocol

Olagunju, Andrew T.; Fadipe, Babatunde; Buraimoh, Rotimi W.; Ale, Olagoke K.; Umeizudike, Theophilus I.; Ogbolu, Raphael E.; Buyinza, Nasur; Bayuo, Jonathan; Mutedzi, Barbara; Nkhoma, Kennedy; Namisango, Eve; Bristowe, Katherine; Yi, Deokhee; Downing, Julia; Aina, Olatunji F.; Adeyemi, Joseph D.; Murtagh, Fliss E.M.; Harding, Richard


Andrew T. Olagunju

Babatunde Fadipe

Rotimi W. Buraimoh

Olagoke K. Ale

Theophilus I. Umeizudike

Raphael E. Ogbolu

Nasur Buyinza

Jonathan Bayuo

Barbara Mutedzi

Kennedy Nkhoma

Eve Namisango

Katherine Bristowe

Deokhee Yi

Julia Downing

Olatunji F. Aina

Joseph D. Adeyemi

Richard Harding



Background: The burden of symptoms and other concerns in chronic kidney disease (CKD) is known to be high, adversely affecting the quality of life of the growing number of those with this condition in developing countries. In this paper, we describe the protocol of a longitudinal observational study among people living with CKD. The study is developed to assess the bio-psychosocial factors associated with palliative care symptoms and concerns, and pattern of health services usage among Nigerians with stages 3–5 CKD. The overall objective is to establish the evidence-base for advocacy and policy formulation, treatment guidelines, care and services, and future clinical trial studies.

Methods: This is a multi-center study to investigate the longitudinal course of symptoms and other concerns among patients with stages 3–5 CKD in Nigeria. Interviewer administered and self-report measures at baseline (T0) and 3-month (T1) address socio-demographic characteristics, clinical-illness related information, palliative care-related symptoms and other concerns, pattern of formal or informal service usage, and bio psychosocial measures including estimated glomerular filtration rate (eGFR), anxiety, depression, quality of life, functioning, social support and spiritual wellbeing.

Discussion: This study represents the first longitudinal investigation of palliative care symptoms and concerns among people with CKD in Nigeria. It includes early stages of CKD in compliance with best practices, and a comprehensive range of bio-psychosocial outcomes to understand how these factors are associated with symptoms. This study will provide evidence for how best to integrate palliative care into management of CKD to improve care and quality of life of people with CKD. The study team welcomes collaborations with both national and international researchers.


Olagunju, A. T., Fadipe, B., Buraimoh, R. W., Ale, O. K., Umeizudike, T. I., Ogbolu, R. E., Buyinza, N., Bayuo, J., Mutedzi, B., Nkhoma, K., Namisango, E., Bristowe, K., Yi, D., Downing, J., Aina, O. F., Adeyemi, J. D., Murtagh, F. E., & Harding, R. (2019). A longitudinal cohort study of symptoms and other concerns among Nigerian people with stages 3–5 chronic kidney diseases: study protocol. Annals of palliative medicine, 8(2), 190-198.

Journal Article Type Article
Acceptance Date Oct 4, 2018
Publication Date 2019-04
Deposit Date Jun 9, 2019
Publicly Available Date Jun 18, 2019
Journal Annals of Palliative Medicine
Print ISSN 2224-5820
Peer Reviewed Peer Reviewed
Volume 8
Issue 2
Pages 190-198
Keywords Anesthesiology and Pain Medicine; Advanced and Specialised Nursing; General Medicine
Public URL
Publisher URL
Contract Date Jun 14, 2019


Article (225 Kb)

Copyright Statement
© Annals of Palliative Medicine. All rights reserved. Shared with permission of the publisher.

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