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Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage

Yaribeygi, Habib; Lhaf, Fadel; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Habib Yaribeygi

Fadel Lhaf

Thozhukat Sathyapalan

Amirhossein Sahebkar

Abstract

Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular mechanisms. Several classes of anti-hyperglycaemic agents have been developed which could potentially modulate the apoptotic process resulting in fewer tissue damages. Novel types of anti-hyperglycaemic medications such as sodium glucose cotransporters-2 inhibitors, glucagon like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors have shown to provide potent anti-hyperglycaemic effects, but their influences on diabetes-induced apoptotic injuries is largely unknown. Therefore, in the current study, we reviewed the published data about the possible effects of these anti-hyperglycaemic agents on apoptosis in diabetic milieu as well as in cancer cells.

Journal Article Type Article
Publication Date 2019-08
Journal Life Sciences
Print ISSN 0024-3205
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 231
Article Number 116538
DOI https://doi.org/10.1016/j.lfs.2019.06.013
Keywords SGLT2 inhibitor; GLP-1 receptor agonist; DPP-4 inhibitor; Oxidative stress; Apoptosis; Diabetes mellitus; Caspase; Cancer

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