Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage

Sathyapalan, Thozhukat; Yaribeygi, Habib; Sahebkar, Amirhossein; Lhaf, Fadel

Abstract

Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular mechanisms. Several classes of anti-hyperglycaemic agents have been developed which could potentially modulate the apoptotic process resulting in fewer tissue damages. Novel types of anti-hyperglycaemic medications such as sodium glucose cotransporters-2 inhibitors, glucagon like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors have shown to provide potent anti-hyperglycaemic effects, but their influences on diabetes-induced apoptotic injuries is largely unknown. Therefore, in the current study, we reviewed the published data about the possible effects of these anti-hyperglycaemic agents on apoptosis in diabetic milieu as well as in cancer cells.

Citation

Sathyapalan, T., Yaribeygi, H., Sahebkar, A., & Lhaf, F. (2019). Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage. Life Sciences, 231, Article 116538. https://doi.org/10.1016/j.lfs.2019.06.013

• Journal Article Type: Article
• Acceptance Date: Jun 5, 2019
• Online Publication Date: Jun 6, 2019
• Publication Date: Aug 15, 2019
• Deposit Date: Jun 10, 2019
• Publicly Available Date: Jun 7, 2020
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 231
• Article Number: 116538
• DOI: https://doi.org/10.1016/j.lfs.2019.06.013
• Keywords: SGLT2 inhibitor; GLP-1 receptor agonist; DPP-4 inhibitor; Oxidative stress; Apoptosis; Diabetes mellitus; Caspase; Cancer
• Public URL: https://hull-repository.worktribe.com/output/1964125
• Contract Date: Jun 11, 2019