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Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms

Frame, Fiona M.; Maitland, Norman J.


Fiona M. Frame

Norman J. Maitland


Fiona Frame

Johng S. Rhim

Richard Kremer


There is now compelling evidence for tumour initiating or cancer stem cells (CSCs) in human cancers. The current evidence of this CSC hypothesis, the CSC phenotype and methods of identification, culture and in vitro modelling will be presented, with an emphasis on prostate cancer. Inherent in the CSC hypothesis is their dual role, as a tumour-initiating cell, and as a source of treatment-resistant cells; the mechanisms behind therapeutic resistance will be discussed. Such resistance is a consequence of the unique CSC phenotype, which differs from the differentiated progeny, which make up the bulk of a tumour. It seems that to target the whole tumour, employing traditional therapies to target bulk populations alongside targeted CSC-specific drugs, provides the best hope of lasting treatment or even cure.


Frame, F. M., & Maitland, N. J. (2011). Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms. In J. S. Rhim, & R. Kremer (Eds.), Human cell transformation, 105-118. Springer.

Acceptance Date Jan 25, 2011
Online Publication Date Aug 11, 2011
Publication Date 2011
Deposit Date Jun 26, 2019
Journal Advances in Experimental Medicine and Biology; Human Cell Transformation
Print ISSN 0065-2598
Pages 105-118
Series Title Advances in experimental medicine and biology
Series Number 720
Book Title Human cell transformation
ISBN 9781461402534
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