Prostate cancer stem cells

Lang, SH; Frame, FM; Collins, AT

Abstract

Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone‐refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell‐like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells.

Citation

Lang, S., Frame, F., & Collins, A. (2009). Prostate cancer stem cells. Journal of Pathology, 217(2), 299-306. https://doi.org/10.1002/path.2478

• Journal Article Type: Article
• Online Publication Date: Oct 29, 2008
• Publication Date: 2009-01
• Deposit Date: Jun 26, 2019
• Journal: The Journal of Pathology
• Print ISSN: 0022-3417
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 217
• Issue: 2
• Pages: 299-306
• DOI: https://doi.org/10.1002/path.2478
• Keywords: Prostate; Stem cells; Neoplasia
• Public URL: https://hull-repository.worktribe.com/output/2044579
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/path.2478