University of Hull logo

Prostate cancer stem cells

Lang, SH; Frame, FM; Collins, AT

Authors

SH Lang

AT Collins

Abstract

Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone‐refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell‐like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells.

Journal Article Type Article
Publication Date 2009-01
Journal The Journal of Pathology
Print ISSN 0022-3417
Electronic ISSN 1096-9896
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 217
Issue 2
Pages 299-306
Institution Citation Lang, S., Frame, F., & Collins, A. (2009). Prostate cancer stem cells. Journal of Pathology, 217(2), 299-306. https://doi.org/10.1002/path.2478
DOI https://doi.org/10.1002/path.2478
Keywords Prostate; Stem cells; Neoplasia
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/path.2478