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A review of the pharmacological and therapeutic effects of auraptene

Bibak, Bahram; Shakeri, Farzaneh; Barreto, George E.; Keshavarzi, Zakieh; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Bahram Bibak

Farzaneh Shakeri

George E. Barreto

Zakieh Keshavarzi

Thozhukat Sathyapalan

Amirhossein Sahebkar


There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the therapeutic benefits of auraptene. Auraptene, also known as auraptene and 7‐geranyloxycoumarin, is a bioactive monoterpene coumarin from Rutaceae family, which is isolated from Citrus aurantium (Seville orange) and Aegle marmelos (bael fruit). Auraptene is a highly pleiotropic molecule, which can modulate intracellular signaling pathways that control inflammation, cell growth, and apoptosis. It has a potential therapeutic role in the prevention and treatment of various diseases due to its anti‐inflammatory and antioxidant activities as well as its excellent safety profile. In the present article, various pharmacological and therapeutic effects of auraptene were reviewed. Different online databases using keywords such as auraptene, therapeutic effects and pharmacological effects were searched until the end of September 2018, for this purpose. Auraptene has been suggested to be effective in the treatment of a broad range of disorders including inflammatory disorders, dysentery, wounds, scars, keloids, and pain. In addition, different studies have demonstrated that auraptene possesses numerous pharmacological properties including anti‐inflammatory, anti‐oxidative, anti‐diabetic, anti‐hypertensive and anti‐cancer as well as neuroprotective effects. The present review provides a detailed survey of scientific researches regarding pharmacological properties and therapeutic effects of auraptene.


Bibak, B., Shakeri, F., Barreto, G. E., Keshavarzi, Z., Sathyapalan, T., & Sahebkar, A. (2019). A review of the pharmacological and therapeutic effects of auraptene. BioFactors, 45(6), 867-879.

Journal Article Type Article
Acceptance Date Jul 26, 2019
Online Publication Date Aug 19, 2019
Publication Date Nov 1, 2019
Deposit Date Aug 20, 2019
Publicly Available Date Aug 20, 2020
Journal BioFactors
Print ISSN 0951-6433
Electronic ISSN 1872-8081
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 45
Issue 6
Pages 867-879
Keywords Auraptene; Chemopreventive; Pharmacological properties
Public URL
Publisher URL
Additional Information This is the accepted manuscript of an article published in BioFactors, 2019. The version of record is available at the DOI link in this record.


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