Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity

Yaribeygi, Habib; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 enzyme metabolizes glucagon-like peptide-1 and various dipeptidyl peptidase-4 enzyme inhibitors (DPP-4i) are also used in the management of diabetes. These antidiabetic agents provide anti-hyperglycemic effects via several molecular mechanisms including promoting insulin secretion, suppression of glucagon secretion and slowing the gastric emptying. There is some research suggesting that they can induce insulin sensitivity in peripheral tissues. In this study, we review the possible molecular mechanisms by which GLP-1RA and DPP-4i can improve insulin resistance and increase insulin sensitivity in insulin-dependent peripheral tissues.

Citation

Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. Life Sciences, 234, Article 116776. https://doi.org/10.1016/j.lfs.2019.116776

• Journal Article Type: Article
• Acceptance Date: Aug 15, 2019
• Online Publication Date: Aug 16, 2019
• Publication Date: Oct 1, 2019
• Deposit Date: Aug 20, 2019
• Publicly Available Date: Aug 17, 2020
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 234
• Article Number: 116776
• DOI: https://doi.org/10.1016/j.lfs.2019.116776
• Keywords: Glucagon-like peptide-1; Glucagon-like peptide-1 receptor agonist; Dipeptidyl peptidase-4 inhibitors; Oxidative stress; GLUT-4; Diabetes mellitus
• Public URL: https://hull-repository.worktribe.com/output/2484329
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0024320519307039?via%3Dihub
• Contract Date: Aug 20, 2019