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Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity

Yaribeygi, Habib; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Habib Yaribeygi

Thozhukat Sathyapalan

Amirhossein Sahebkar


Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 enzyme metabolizes glucagon-like peptide-1 and various dipeptidyl peptidase-4 enzyme inhibitors (DPP-4i) are also used in the management of diabetes. These antidiabetic agents provide anti-hyperglycemic effects via several molecular mechanisms including promoting insulin secretion, suppression of glucagon secretion and slowing the gastric emptying. There is some research suggesting that they can induce insulin sensitivity in peripheral tissues. In this study, we review the possible molecular mechanisms by which GLP-1RA and DPP-4i can improve insulin resistance and increase insulin sensitivity in insulin-dependent peripheral tissues.


Yaribeygi, H., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity. Life Sciences, 234,

Journal Article Type Article
Acceptance Date Aug 15, 2019
Online Publication Date Aug 16, 2019
Publication Date Oct 1, 2019
Deposit Date Aug 20, 2019
Publicly Available Date Aug 17, 2020
Journal Life Sciences
Print ISSN 0024-3205
Electronic ISSN 1879-0631
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 234
Article Number 116776
Keywords Glucagon-like peptide-1; Glucagon-like peptide-1 receptor agonist; Dipeptidyl peptidase-4 inhibitors; Oxidative stress; GLUT-4; Diabetes mellitus
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