Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome

Butler, Alexandra E.; Hayat, Shahina; Dargam, Soha R; Malek, Joel A; Abdullah, Silvana A; Mahmoud, Yasmin A; Suhre, Karsten; Sathyapalan, Thozhukat; Atkin, Stephen L.

Abstract

Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides long that are not translated into protein; however, there is increasing evidence of their regulatory functions. To date, there are few studies measuring lncRNA in control women or women with polycystic ovary syndrome (PCOS). Objective: To determine lncRNA differences between PCOS and control women. Design: Cross sectional study. Patients: Twenty four anovulatory women with all three diagnostic features of PCOS compared to 24 control women in the follicular phase of their menstrual cycle from a PCOS biobank. Results: Women with PCOS were age and weight matched compared to the control women but were significantly insulin resistant and hyperandrogenemic (P

Citation

Butler, A. E., Hayat, S., Dargam, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., Suhre, K., Sathyapalan, T., & Atkin, S. L. (2019). Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome. Clinical Endocrinology, 91(6), 793-797. https://doi.org/10.1111/cen.14087

• Journal Article Type: Article
• Acceptance Date: Sep 2, 2019
• Online Publication Date: Sep 4, 2019
• Publication Date: Dec 1, 2019
• Deposit Date: Sep 5, 2019
• Publicly Available Date: Mar 5, 2021
• Journal: Clinical Endocrinology
• Print ISSN: 0300-0664
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 91
• Issue: 6
• Pages: 793-797
• DOI: https://doi.org/10.1111/cen.14087
• Keywords: Endocrinology, Diabetes and Metabolism
• Public URL: https://hull-repository.worktribe.com/output/2614136
• Additional Information: Published: 2019-09-04
• Contract Date: Sep 5, 2019