University of Hull logo

Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome

Butler, Alexandra E.; Hayat, Shahina; Dargam, Soha R; Malek, Joel A; Abdullah, Silvana A; Mahmoud, Yasmin A; Suhre, Karsten; Sathyapalan, Thozhukat; Atkin, Stephen L.

Authors

Alexandra E. Butler

Shahina Hayat

Soha R Dargam

Joel A Malek

Silvana A Abdullah

Yasmin A Mahmoud

Karsten Suhre

Thozhukat Sathyapalan

Stephen L. Atkin

Abstract

Long non‐coding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides long that are not translated into protein; however, there is increasing evidence of their regulatory functions. To date, there are few studies measuring lncRNA in control women or women with polycystic ovary syndrome (PCOS).

Objective
To determine lncRNA differences between PCOS and control women.

Methods
LncRNA were measured in 24 anovulatory women with all three diagnostic features of PCOS compared to 24 control women in the follicular phase of their menstrual cycle from a PCOS biobank.

Results
Women with PCOS were age and weight matched compared to the control women but were significantly insulin resistant and hyperandrogenemic (p

Journal Article Type Article
Publication Date Sep 4, 2019
Journal Clinical Endocrinology
Print ISSN 0300-0664
Electronic ISSN 1365-2265
Publisher Wiley
Peer Reviewed Peer Reviewed
Institution Citation Butler, A. E., Hayat, S., Dargam, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., …Atkin, S. L. (2019). Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome. Clinical Endocrinology, https://doi.org/10.1111/cen.14087
DOI https://doi.org/10.1111/cen.14087
Keywords Endocrinology, Diabetes and Metabolism
Additional Information Published: 2019-09-04

This file is under embargo due to copyright reasons.

Contact T.Sathyapalan@hull.ac.uk to request a copy for personal use.



Downloadable Citations