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Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome

Butler, Alexandra E.; Hayat, Shahina; Dargam, Soha R; Malek, Joel A; Abdullah, Silvana A; Mahmoud, Yasmin A; Suhre, Karsten; Sathyapalan, Thozhukat; Atkin, Stephen L.


Alexandra E. Butler

Shahina Hayat

Soha R Dargam

Joel A Malek

Silvana A Abdullah

Yasmin A Mahmoud

Karsten Suhre

Thozhukat Sathyapalan

Stephen L. Atkin


Long non‐coding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides long that are not translated into protein; however, there is increasing evidence of their regulatory functions. To date, there are few studies measuring lncRNA in control women or women with polycystic ovary syndrome (PCOS).

To determine lncRNA differences between PCOS and control women.

LncRNA were measured in 24 anovulatory women with all three diagnostic features of PCOS compared to 24 control women in the follicular phase of their menstrual cycle from a PCOS biobank.

Women with PCOS were age and weight matched compared to the control women but were significantly insulin resistant and hyperandrogenemic (p

Journal Article Type Article
Publication Date Sep 4, 2019
Journal Clinical Endocrinology
Print ISSN 0300-0664
Electronic ISSN 1365-2265
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Butler, A. E., Hayat, S., Dargam, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., …Atkin, S. L. (2019). Alterations in long non‐coding RNAs in women with and without Polycystic Ovarian Syndrome. Clinical Endocrinology,
Keywords Endocrinology, Diabetes and Metabolism
Additional Information Published: 2019-09-04