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The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Habib Yaribeygi

Mina Maleki

Thozhukat Sathyapalan

Amirhossein Sahebkar



Abstract

C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstrates that it has other physiologic activities beyond its structural function. C-peptide modulates intracellular signaling pathways in various pathophysiologic states and, could potentially be a new therapeutic target for different disorders including diabetic complications. There is growing evidence that c-peptide has modulatory effects on the molecular mechanisms involved in the development of diabetic nephropathy. Although we have little direct evidence, pharmacological properties of c-peptide suggest that it can provide potent renoprotective effects especially, in a c-peptide deficient milieu as in type 1 diabetes mellitus. In this review, we describe possible molecular mechanisms by which c-peptide may improve renal efficiency in a diabetic milieu.

Journal Article Type Article
Publication Date Nov 15, 2019
Journal Life Sciences
Print ISSN 0024-3205
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 237
Pages 116950
APA6 Citation Yaribeygi, H., Maleki, M., Sathyapalan, T., & Sahebkar, A. (2019). The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sciences, 237, 116950. https://doi.org/10.1016/j.lfs.2019.116950
DOI https://doi.org/10.1016/j.lfs.2019.116950
Keywords Diabetes mellitus; Diabetic nephropathy; C-peptide; Oxidative stress; NF-κB; Nitric oxide
Publisher URL https://www.sciencedirect.com/science/article/pii/S002432051930877X
Additional Information This article is maintained by: Elsevier; Article Title: The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms; Journal Title: Life Sciences; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.lfs.2019.116950; Content Type: article; Copyright: © 2019 Published by Elsevier Inc.
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