The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstrates that it has other physiologic activities beyond its structural function. C-peptide modulates intracellular signaling pathways in various pathophysiologic states and, could potentially be a new therapeutic target for different disorders including diabetic complications. There is growing evidence that c-peptide has modulatory effects on the molecular mechanisms involved in the development of diabetic nephropathy. Although we have little direct evidence, pharmacological properties of c-peptide suggest that it can provide potent renoprotective effects especially, in a c-peptide deficient milieu as in type 1 diabetes mellitus. In this review, we describe possible molecular mechanisms by which c-peptide may improve renal efficiency in a diabetic milieu.

Citation

Yaribeygi, H., Maleki, M., Sathyapalan, T., & Sahebkar, A. (2019). The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sciences, 237, Article 116950. https://doi.org/10.1016/j.lfs.2019.116950

• Journal Article Type: Review
• Acceptance Date: Sep 8, 2019
• Online Publication Date: Oct 9, 2019
• Publication Date: Nov 15, 2019
• Deposit Date: Oct 22, 2019
• Publicly Available Date: Oct 10, 2020
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 237
• Article Number: 116950
• DOI: https://doi.org/10.1016/j.lfs.2019.116950
• Keywords: Diabetes mellitus; Diabetic nephropathy; C-peptide; Oxidative stress; NF-κB; Nitric oxide
• Public URL: https://hull-repository.worktribe.com/output/2975798
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S002432051930877X
• Additional Information: This article is maintained by: Elsevier; Article Title: The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms; Journal Title: Life Sciences; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.lfs.2019.116950; Content Type: article; Copyright: © 2019 Published by Elsevier Inc.
• Contract Date: Oct 22, 2019