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Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents

Barbian, Cláudia Daniela; Reuter, Cézane Priscila; Renner, Jane Dagmar Pollo; da Silva, Priscila Tatiana; Klinger, Elisa Inês; Hobkirk, James Philip; de Moura Valim, Andréia Rosane; Burgos, Miria Suzana

Authors

Cláudia Daniela Barbian

Cézane Priscila Reuter

Jane Dagmar Pollo Renner

Priscila Tatiana da Silva

Elisa Inês Klinger

Andréia Rosane de Moura Valim

Miria Suzana Burgos



Abstract

Few studies show the potential changing effect of fat-mass and obesity-associated (FTO) rs9939609 gene on cardiometabolic risk after a lifestyle intervention. This study aims to evaluate whether overweight and obese adolescents, carriers of the risk genotypes for obesity of the FTO rs9939609 gene polymorphism, have different
anthropometric and biochemical responses to an interdisciplinary intervention program. The quasi-experimental study involved 34 adolescents aged 10 to 15 years. Schoolchildren with AA/AT genotype decreased glucose, total cholesterol, low-density
lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. However, there were no differences between the genotypes, suggesting that the “A” allele did not modify the subject’s response to the intervention program.

Citation

Barbian, C. D., Reuter, C. P., Renner, J. D. P., da Silva, P. T., Klinger, E. I., Hobkirk, J. P., …Burgos, M. S. (2020). Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents. Journal of Pediatric Genetics, 9(1), 019-026. https://doi.org/10.1055/s-0039-3399511

Journal Article Type Article
Acceptance Date Sep 25, 2019
Online Publication Date Nov 7, 2019
Publication Date 2020-03
Deposit Date Feb 4, 2020
Publicly Available Date Nov 8, 2020
Journal Journal of Pediatric Genetics
Electronic ISSN 2146-460X
Publisher Thieme Publishers
Peer Reviewed Peer Reviewed
Volume 9
Issue 1
Pages 019-026
DOI https://doi.org/10.1055/s-0039-3399511
Keywords Clinical trial; Obesity; Genetic polymorphism
Public URL https://hull-repository.worktribe.com/output/3405172
Publisher URL https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-3399511

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