Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents

Barbian, Cláudia Daniela; Reuter, Cézane Priscila; Renner, Jane Dagmar Pollo; da Silva, Priscila Tatiana; Klinger, Elisa Inês; Hobkirk, James Philip; de Moura Valim, Andréia Rosane; Burgos, Miria Suzana

Abstract

Few studies show the potential changing effect of fat-mass and obesity-associated (FTO) rs9939609 gene on cardiometabolic risk after a lifestyle intervention. This study aims to evaluate whether overweight and obese adolescents, carriers of the risk genotypes for obesity of the FTO rs9939609 gene polymorphism, have different
anthropometric and biochemical responses to an interdisciplinary intervention program. The quasi-experimental study involved 34 adolescents aged 10 to 15 years. Schoolchildren with AA/AT genotype decreased glucose, total cholesterol, low-density
lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. However, there were no differences between the genotypes, suggesting that the “A” allele did not modify the subject’s response to the intervention program.

Citation

Barbian, C. D., Reuter, C. P., Renner, J. D. P., da Silva, P. T., Klinger, E. I., Hobkirk, J. P., de Moura Valim, A. R., & Burgos, M. S. (2020). Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents. Journal of Pediatric Genetics, 9(1), 019-026. https://doi.org/10.1055/s-0039-3399511

• Journal Article Type: Article
• Acceptance Date: Sep 25, 2019
• Online Publication Date: Nov 7, 2019
• Publication Date: 2020-03
• Deposit Date: Feb 4, 2020
• Publicly Available Date: Nov 8, 2020
• Journal: Journal of Pediatric Genetics
• Electronic ISSN: 2146-4596
• Publisher: Thieme Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 1
• Pages: 019-026
• DOI: https://doi.org/10.1055/s-0039-3399511
• Keywords: Clinical trial; Obesity; Genetic polymorphism
• Public URL: https://hull-repository.worktribe.com/output/3405172
• Publisher URL: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-3399511