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Cough persistence in adults with chronic cough: a 4-year retrospective cohort study

Kang, Sung Yoon; Song, Woo Jung; Won, Ha Kyeong; Chung, Soo Jie; Kim, Ju Young; Park, Heung Woo; Morice, Alyn H.; Cho, Sang-Heon

Authors

Sung Yoon Kang

Woo Jung Song

Ha Kyeong Won

Soo Jie Chung

Ju Young Kim

Heung Woo Park

Sang-Heon Cho



Abstract

Background
There is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence.
Methods
A retrospective cohort was constructed of adults who had newly visited a specialist cough clinic in 2012–2013. All had undergone systematic investigation for chronic cough. The Hull Airway Reflux Questionnaire (HARQ) was administered to assess reflux cough symptoms. A follow-up survey was conducted in 2016–2017 to assess cough persistence.
Results
From 418 candidates, 323 participated in the follow-up study; main analyses focused on patients with chronic persistent cough (n=64; 19.8%) and remitted cough (n=193; 59.8%). Compared with remitted cough, chronic persistent cough group had more family history of chronic cough (17.2% vs. 4.7%, p=0.001) and cold air-sensitive cough (62.5% vs. 44.6%, p=0.013). The total HARQ score did not differ; however, two items (cough with eating and cough with certain foods) scored significantly higher in chronic persistent cough. In multivariate analyses, a family history of chronic cough (adjusted odds ratio 4.27 [95% confidence interval 1.35-9.89]), cold air-sensitive cough (2.01 [1.09-3.73]), and cough with eating (1.22 [1.02–1.45]) were associated with chronic persistent cough at 4 years.
Conclusions
Cough persists in about 20% of patients after 4 years following systematic assessment and treatments. Several cough characteristics, such as family history, cold air-sensitivity, or reflux cough, may be associated with cough persistence. Larger cohort studies are warranted to further understand long-term prognosis and confirm predictors of persistence in patients with chronic cough.

Citation

Kang, S. Y., Song, W. J., Won, H. K., Chung, S. J., Kim, J. Y., Park, H. W., … Cho, S. (2020). Cough persistence in adults with chronic cough: a 4-year retrospective cohort study. Allergology International, 69(4), 588-593. https://doi.org/10.1016/j.alit.2020.03.012

Journal Article Type Article
Acceptance Date Mar 23, 2020
Online Publication Date Apr 20, 2020
Publication Date 2020-10
Deposit Date Apr 1, 2020
Publicly Available Date Mar 29, 2024
Journal Allergology International
Print ISSN 1323-8930
Electronic ISSN 1440-1592
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 69
Issue 4
Pages 588-593
DOI https://doi.org/10.1016/j.alit.2020.03.012
Keywords Chronic cough; Epidemiology; Longitudinal outcome; Predictor; Retrospective cohort study
Public URL https://hull-repository.worktribe.com/output/3481376
Publisher URL https://www.sciencedirect.com/science/article/pii/S1323893020300496

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