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Water‐soluble rhenium clusters with triazoles: the effect of chemical structure on cellular internalization and the DNA binding of the complexes

Konovalov, Dmitry I.; Ivanov, Anton A.; Frolova, Tatiana S.; Eltsov, Ilia V.; Gayfulin, Yakov M.; Plunkett, Louis; Bazzar, Masoomeh; Adawi, Ali M.; Bouillard, Jean Sebastien G.; Baiborodin, Sergey I.; Sinitsyna, Olga I.; Kuratieva, Natalia V.; Yanshole, Vadim V.; Efremova, Olga A.; Shestopalov, Michael A.

Authors

Dmitry I. Konovalov

Anton A. Ivanov

Tatiana S. Frolova

Ilia V. Eltsov

Yakov M. Gayfulin

Louis Plunkett

Masoomeh Bazzar

Sergey I. Baiborodin

Olga I. Sinitsyna

Natalia V. Kuratieva

Vadim V. Yanshole

Olga A. Efremova

Michael A. Shestopalov



Abstract

Here we explore the effect of the nature of organic ligands in rhenium cluster complexes [Re6Q8L6]4− (where Q=S or Se, and L=benzotriazole, 1,2,3-triazole or 1,2,4-triazole) on the biological properties of the complexes, in particular on the cellular toxicity, cellular internalization and localization. Specifically, the study describes the synthesis and detailed characterization of the structure, luminescence and electrochemical properties of the four new Re6 clusters with 1,2,3- and 1,2,4-triazoles. Biological assays of these complexes are also discussed in addition to those with benzotriazole using cervical cancer (HeLa) and immortalized human fibroblasts (CRL-4025) as model cell lines. Our study demonstrates that the presence of hydrophobic and π-bonding rich units such as the benzene ring in benzotriazole significantly enhances cellular internalization of rhenium clusters. These ligands facilitate binding of the clusters to DNA, which results in increased cytotoxicity of the complexes.

Citation

Konovalov, D. I., Ivanov, A. A., Frolova, T. S., Eltsov, I. V., Gayfulin, Y. M., Plunkett, L., …Shestopalov, M. A. (2020). Water‐soluble rhenium clusters with triazoles: the effect of chemical structure on cellular internalization and the DNA binding of the complexes. Chemistry : a European journal, 26(61), 13904-13914. https://doi.org/10.1002/chem.202001680

Journal Article Type Article
Acceptance Date May 26, 2020
Online Publication Date May 26, 2020
Publication Date Nov 2, 2020
Deposit Date Jun 1, 2020
Publicly Available Date Nov 3, 2021
Journal Chemistry: a European journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 26
Issue 61
Pages 13904-13914
DOI https://doi.org/10.1002/chem.202001680
Keywords Rhenium cluster; Triazoles; Luminescence; Cytotoxicity; DNA binding
Public URL https://hull-repository.worktribe.com/output/3514728
Publisher URL https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202001680
Additional Information Received: 2020-04-07; Accepted: 2020-05-26; Published: 2020-05-26

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Copyright Statement
This is the peer reviewed version of the following article: D. I. Konovalov, A. A. Ivanov, T. S. Frolova, I. V. Eltsov, Y. M. Gayfulin, L. Plunkett, M. Bazzar, A. M. Adawi, J.-S. G. Bouillard, S. I. Baiborodin, O. I. Sinitsyna, N. V. Kuratieva, V. V. Yanshole, O. A. Efremova, M. A. Shestopalov, Chem. Eur. J. 2020, 26, 13904., which has been published in final form at https://doi.org/10.1002/chem.202001680.  This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.







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