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Triggers of Breathlessness in Inducible Laryngeal Obstruction and Asthma

Haines, Jemma; Chua, Sarah HK; Smith, Jacky; Slinger, Claire; Simpson, Andrew J.; Fowler, Stephen J

Authors

Jemma Haines

Sarah HK Chua

Jacky Smith

Claire Slinger

Stephen J Fowler



Abstract

Background
Inducible laryngeal obstruction (ILO) is often misdiagnosed as, or may coexist with, asthma. Identifying differences in triggering factors may assist clinicians to differentiate between the two conditions, and could give mechanistic insights.

Objective
To identify and compare patient‐reported triggers in ILO and asthma.

Methods
This was a two‐part study. Initially we conducted a retrospective case note review of the triggers of ILO from endoscopically‐confirmed ILO patients to generate a Breathlessness Triggers Survey (BrTS). Triggers were categorised as: scents, environmental factors, temperature, emotions, mechanical factors and daily activities. Secondly, ILO and/or asthma patients completed the BrTS prospectively, rating the likelihood of each item triggering their symptoms using a five‐point Likert scale (strongly disagree to strongly agree). Chi‐square testing was performed to compare responses by cohort.

Results
Data from 202 patients with ILO [73% female, mean (SD) age 53(16) years] were included in the case note review. For the prospective study, 38 patients with ILO‐only [63% females, age 57(16) years], 39 patients with asthma‐only [(56% female, age 53(13) years] and 12 patients with both ILO and asthma [83% female, mean age, 57 (14) years)] completed the BrTS. The triggers identified in the case note review were confirmed in the independent sample of patients with ILO and/or asthma and identified several difference in prevalence of the triggers between disease types. Mechanical factors [talking (p

Citation

Haines, J., Chua, S. H., Smith, J., Slinger, C., Simpson, A. J., & Fowler, S. J. (2020). Triggers of Breathlessness in Inducible Laryngeal Obstruction and Asthma. Clinical and Experimental Allergy, 50(11), 1230-1237. https://doi.org/10.1111/cea.13715

Journal Article Type Article
Acceptance Date Jul 14, 2020
Online Publication Date Jul 26, 2020
Publication Date 2020-11
Deposit Date Jul 27, 2020
Publicly Available Date Jul 27, 2020
Journal Clinical and Experimental Allergy
Print ISSN 0954-7894
Electronic ISSN 1365-2222
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 50
Issue 11
Pages 1230-1237
DOI https://doi.org/10.1111/cea.13715
Keywords Allergens and epitopes; Asthma; Environment; Hygiene hypothesis and Inducible laryngeal obstruction
Public URL https://hull-repository.worktribe.com/output/3548183
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13715
Additional Information Published: 2020-07-26

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
This article is protected by copyright. All rights reserved. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


Published article (451 Kb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.





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