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“How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer

Simmons, Claribel; McMillan, Donald C.; Tuck, Sharon; Graham, Cat; McKeown, Alistair; Bennett, Mike; O'Neill, Claire; Wilcock, Andrew; Usborne, Caroline; Fearon, Kenneth C.; Fallon, Marie; Laird, Barry J.; Lingesan, G.; Franks, A.; Chaitanya, V.; Chauhan, A.; Stuart, N.; Ross, C.; Isherwood, R.; Johnson, M.; Zacharias, H.; Gould, A.; Turner, C.; Durrani

Authors

Claribel Simmons

Donald C. McMillan

Sharon Tuck

Cat Graham

Alistair McKeown

Mike Bennett

Claire O'Neill

Andrew Wilcock

Caroline Usborne

Kenneth C. Fearon

Marie Fallon

Barry J. Laird

G. Lingesan

A. Franks

V. Chaitanya

A. Chauhan

N. Stuart

C. Ross

R. Isherwood

H. Zacharias

A. Gould

C. Turner

Durrani



Abstract

© AlphaMed Press 2019 Background: The optimal prognostic factors in patients with advanced cancer are not known, as a comparison of these is lacking. The aim of the present study was to determine the optimal prognostic factors by comparing validated factors. Materials and Methods: A multicenter, prospective observational cohort study recruited patients over 18 years with advanced cancer. The following were assessed: clinician-predicted survival (CPS), Eastern Cooperative Oncology Group performance status (ECOG-PS), patient reported outcome measures (anorexia, cognitive impairment, dyspnea, global health), metastatic disease, weight loss, modified Glasgow Prognostic Score (mGPS) based on C-reactive protein and albumin, lactate dehydrogenase (LDH), and white (WCC), neutrophil (NC), and lymphocyte cell counts. Survival at 1 and 3 months was assessed using area under the receiver operating curve and logistic regression analysis. Results: Data were available on 478 patients, and the median survival was 4.27 (1.86–7.03) months. On univariate analysis, the following factors predicted death at 1 and 3 months: CPS, ECOG-PS, mGPS, WCC, NC (all p

Citation

Simmons, C., McMillan, D. C., Tuck, S., Graham, C., McKeown, A., Bennett, M., O'Neill, C., Wilcock, A., Usborne, C., Fearon, K. C., Fallon, M., Laird, B. J., Lingesan, G., Franks, A., Chaitanya, V., Chauhan, A., Stuart, N., Ross, C., Isherwood, R., Johnson, M., …Durrani. (2019). “How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer. Oncologist, 24(9), e960-e967. https://doi.org/10.1634/theoncologist.2018-0474

Journal Article Type Article
Acceptance Date Feb 21, 2019
Online Publication Date Apr 12, 2019
Publication Date Sep 1, 2019
Deposit Date May 3, 2022
Publicly Available Date May 9, 2022
Journal Oncologist
Print ISSN 1083-7159
Electronic ISSN 1549-490X
Publisher AlphaMed Press
Peer Reviewed Peer Reviewed
Volume 24
Issue 9
Pages e960-e967
DOI https://doi.org/10.1634/theoncologist.2018-0474
Keywords Prognosis; Inflammation; Survival; Cancer; Palliative
Public URL https://hull-repository.worktribe.com/output/3594368

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