“How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer

Simmons, Claribel; McMillan, Donald C.; Tuck, Sharon; Graham, Cat; McKeown, Alistair; Bennett, Mike; O'Neill, Claire; Wilcock, Andrew; Usborne, Caroline; Fearon, Kenneth C.; Fallon, Marie; Laird, Barry J.; Lingesan, G.; Franks, A.; Chaitanya, V.; Chauhan, A.; Stuart, N.; Ross, C.; Isherwood, R.; Johnson, M.; Zacharias, H.; Gould, A.; Turner, C.; Durrani

Abstract

© AlphaMed Press 2019 Background: The optimal prognostic factors in patients with advanced cancer are not known, as a comparison of these is lacking. The aim of the present study was to determine the optimal prognostic factors by comparing validated factors. Materials and Methods: A multicenter, prospective observational cohort study recruited patients over 18 years with advanced cancer. The following were assessed: clinician-predicted survival (CPS), Eastern Cooperative Oncology Group performance status (ECOG-PS), patient reported outcome measures (anorexia, cognitive impairment, dyspnea, global health), metastatic disease, weight loss, modified Glasgow Prognostic Score (mGPS) based on C-reactive protein and albumin, lactate dehydrogenase (LDH), and white (WCC), neutrophil (NC), and lymphocyte cell counts. Survival at 1 and 3 months was assessed using area under the receiver operating curve and logistic regression analysis. Results: Data were available on 478 patients, and the median survival was 4.27 (1.86–7.03) months. On univariate analysis, the following factors predicted death at 1 and 3 months: CPS, ECOG-PS, mGPS, WCC, NC (all p

Citation

Simmons, C., McMillan, D. C., Tuck, S., Graham, C., McKeown, A., Bennett, M., O'Neill, C., Wilcock, A., Usborne, C., Fearon, K. C., Fallon, M., Laird, B. J., Lingesan, G., Franks, A., Chaitanya, V., Chauhan, A., Stuart, N., Ross, C., Isherwood, R., Johnson, M., …Durrani. (2019). “How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer. Oncologist, 24(9), e960-e967. https://doi.org/10.1634/theoncologist.2018-0474

• Journal Article Type: Article
• Acceptance Date: Feb 21, 2019
• Online Publication Date: Apr 12, 2019
• Publication Date: Sep 1, 2019
• Deposit Date: May 3, 2022
• Publicly Available Date: May 9, 2022
• Journal: Oncologist
• Print ISSN: 1083-7159
• Electronic ISSN: 1549-490X
• Publisher: AlphaMed Press
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 9
• Pages: e960-e967
• DOI: https://doi.org/10.1634/theoncologist.2018-0474
• Keywords: Prognosis; Inflammation; Survival; Cancer; Palliative
• Public URL: https://hull-repository.worktribe.com/output/3594368