“How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer

Simmons, Claribel; McMillan, Donald C.; Tuck, Sharon; Graham, Cat; McKeown, Alistair; Bennett, Mike; O'Neill, Claire; Wilcock, Andrew; Usborne, Caroline; Fearon, Kenneth C.; Fallon, Marie; Laird, Barry J.; Lingesan, G.; Franks, A.; Chaitanya, V.; Chauhan, A.; Stuart, N.; Ross, C.; Isherwood, R.; Johnson, M.; Zacharias, H.; Gould, A.; Turner, C.; Durrani

Abstract

© AlphaMed Press 2019 Background: The optimal prognostic factors in patients with advanced cancer are not known, as a comparison of these is lacking. The aim of the present study was to determine the optimal prognostic factors by comparing validated factors. Materials and Methods: A multicenter, prospective observational cohort study recruited patients over 18 years with advanced cancer. The following were assessed: clinician-predicted survival (CPS), Eastern Cooperative Oncology Group performance status (ECOG-PS), patient reported outcome measures (anorexia, cognitive impairment, dyspnea, global health), metastatic disease, weight loss, modified Glasgow Prognostic Score (mGPS) based on C-reactive protein and albumin, lactate dehydrogenase (LDH), and white (WCC), neutrophil (NC), and lymphocyte cell counts. Survival at 1 and 3 months was assessed using area under the receiver operating curve and logistic regression analysis. Results: Data were available on 478 patients, and the median survival was 4.27 (1.86–7.03) months. On univariate analysis, the following factors predicted death at 1 and 3 months: CPS, ECOG-PS, mGPS, WCC, NC (all p

Citation

Simmons, C., McMillan, D. C., Tuck, S., Graham, C., McKeown, A., Bennett, M., …Durrani. (2019). “How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer. Oncologist, 24(9), e960-e967. https://doi.org/10.1634/theoncologist.2018-0474

• Journal Article Type: Article
• Acceptance Date: Feb 21, 2019
• Online Publication Date: Apr 12, 2019
• Publication Date: Sep 1, 2019
• Deposit Date: May 3, 2022
• Publicly Available Date: May 9, 2022
• Journal: Oncologist
• Print ISSN: 1083-7159
• Electronic ISSN: 1549-490X
• Publisher: AlphaMed Press
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 9
• Pages: e960-e967
• DOI: https://doi.org/10.1634/theoncologist.2018-0474
• Keywords: Prognosis; Inflammation; Survival; Cancer; Palliative
• Public URL: https://hull-repository.worktribe.com/output/3594368